Articles tagged "Liver transplantation"

2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
Modified Upper Abdominal Organ Cluster Transplantation: A Serial of 16 Cases in a Single Center
J. Zhou, W. Ju, X. Yuan, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Objectives: Various postoperatively complications and high mortality rate are the major difficulties in early classical total and subtotal abdominal organ transplantation. To improve long-term survival,…
2015 American Transplant Congress
Early Allograft Dysfunction Causes Inferior Patient and Allograft Survival in Liver Transplantation; an Experience of 1952 Consecutive Liver Transplants
D. Lee, K. Croome, J. Burns, D. Perry, J. Nguyen, H. Crespo, C. Taner.
Transplantation, Mayo Clinic, Jacksonville, FL.
Background: Early allograft dysfunction (EAD) in liver transplantation (LT) is a useful intermediate outcome measure to predict graft loss or mortality. We sought to investigate…
2015 American Transplant Congress
The Impact of the New Antivirals Sofosfuvir/Ledipasvir on Liver Transplantation for Hepatitis C Cirrhosis
S. Munoz,¹ D. Reich,² K. Rothstein.¹
¹Div of Hepatology, Liver Failure Unit, Hanemann University Hospital, Philadelphia, PA; ²Liver, Kidney and Pancreas Transplant Program, Hahnemann University Hospital, Philadelphia, PA.
The approval of potent antiviral therapy (AVT) with sofosfuvir/ledipasvir (sof/ldv) for hepatitis C (HCV) dramatically increased cure rates (SVR) to nearly 100%. A recent prospective…
2015 American Transplant Congress
The Impact of Acute Rejection on Liver Transplant Survival in the New Millennium
J. Levitsky,¹ S. Forney,² B. Gillespie,³ R. Merion,^2,3 A. Lok,³ G. Levy,⁴ L. Kulik,¹ M. Abecassis,¹ A. Shaked.⁵
¹Northwestern U, Chicago, IL; ²Arbor Research Collaborative for Health, Ann Arbor, MI; ³U Michigan, Ann Arbor, MI; ⁴U Toronto, Toronto, ON, Canada; ⁵U Pennsylvania, Philadelphia, PA.
Background: Based on pre-2000 data, acute rejection (AR) has long been considered clinically less significant in liver transplant (LT) vs. other organ recipients (Charlton et…
2015 American Transplant Congress
Donor Organ Resident M2 Type Myeloid Cells Protect Murine Orthotropic Liver Transplants from Ischemia and Reperfusion Injury
S. Yue, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.
The Dumont-UCLA Transplant Ctr., UCLA, Los Angeles, CA.
Liver ischemia reperfusion injury (lRI) is mediated by a pro-inflammatory immune response initiated by the activation of liver non-parenchymal innate immune cells, such as Kupffer…
2015 American Transplant Congress
Forty-Seven Consecutive Simultaneous Liver-Kidney Transplants With Steroid Free Immunosuppression After Rabbit Antithymocyte Globulin Induction
D. Hall, V. Puri, S. Mabry, J. Vanatta, J. Eason.
Transplantation, University of Tennessee/Methodist University Hospital Transplant Institute, Memphis, TN.
Introduction: Utilization of rabbit antithymocyte globulin (RATG) induction as part of a steroid free immunosuppression protocol in orthotopic liver transplantation has gained wide acceptance in…
2015 American Transplant Congress
Financial Impact of an Advanced Liver Disease Service on a Tertiary Health System
A. Masoumi,¹ S. Hanish,² J. LaMattina,² C. Njoka,¹ W. Hutson,² D. Potosky,² R. Barth.²
¹University of Maryland Medical Center, Baltimore; ²University of Maryland School of Medicine, Baltimore.
Regional disparities in liver transplantation motivated revision of national organ-sharing policies towards critically ill patients. Liver transplantation of high MELD patients incorporates significant institutional commitment…
2015 American Transplant Congress
The Product of Donor Age and Preoperative MELD, D-MELD, Predicts Surgical Outcomes After LDLT, When Using Small Graft
A. Tanemura, S. Mizuno, H. Kato, Y. Murata, N. Kuriyama, Y. Azumi, M. Kishiwada, M. Usui, H. Sakurai, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Background:Donor-recipient match is recognized as the factor well predicting recipient outcome in deceased donor liver transplantation. The aim of the present study is to evaluate…
2015 American Transplant Congress
Historical Comparison of Projected and Observed Liver Transplants
J. Pyke,¹ D. Schladt,¹ W. Kim,⁵ S. Leppke,¹ J. Lake,⁴ S. Gentry,^2,3 D. Segev,² A. Israni,¹ J. Snyder.¹
¹SRTR, Minneapolis Medical Research Foundation, Minneapolis, MN; ²Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ³Mathematics, US Naval Academy, Baltimore, MD; ⁴Medicine and Surgery, University of Minnesota Medical School, Minneapolis, MN; ⁵School of Medicine, Stanford University, Stanford, CA.
We aimed to compare liver transplant simulation projections to observed data before and after a major policy update. The current liver simulated allocation model (LSAM…