Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Complement Activation and Delayed Graft Function after Kidney Transplantation
C. Arias-Cabrales¹, M. Pérez-Sáez¹, M. Riera¹, J. Gimeno², D. Benito¹, D. Redondo-Pachón¹, A. Buxeda¹, C. Burballa¹, M. Crespo¹, J. Pascual¹, E. Rodríguez¹
¹Nephrology, Hospital Del Mar, Barcelona, Spain, ²Pathology, Hospital Del Mar, Barcelona, Spain
*Purpose: Ischemia-reperfusion (I/R) damage is the most important cause of delayed graft function (DGF), which has a negative impact on kidney transplant (KT) outcomes. Complement…
2020 American Transplant Congress
A Technique for Ex-Vivo Perfusion of Donor Kidneys for Transplantation in the Mouse
R. Plenter¹, S. Jain², J. J. Pomposelli¹, T. Nydam¹, A. Jani²
¹Pulmonary Division, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Ex-vivo perfusion of donor kidneys is widely employed in the US and significantly reduces DGF. Development of a pre-clinical perfusion technique may provide an…
2020 American Transplant Congress
Comparison of 1-Year Incidence of De Novo Donor Specific Antibodies between Thymoglobulin and Alemtuzumab Induction in Kidney Transplantation
J. P. Knorr, C. Kallis, D. A. Portley, A. Jeyarajasingam, P. W. Lai, G. Bradauskaite, K. Khanmoradi
Transplant Nephrology, Einstein Medical Center, Philadelphia, PA
*Purpose: Development of de novo donor specific antibodies (dnDSA) after kidney transplantation (KTx) has been associated with acute and chronic antibody-mediated rejection, transplant glomerulopathy and…
2020 American Transplant Congress
Outcomes after Declining Offers from Older Donor Kidneys for Kidney Transplant Candidates
J. D. Motter, L. Liyanage, K. R. Jackson, M. G. Bowring, T. Ishaque, Y. Yu, S. Yu, J. M. Garonzik-Wang, A. B. Massie, D. L. Segev
Johns Hopkins University, Baltimore, MD
*Purpose: Older donor kidneys (ODKs) are often declined as they are associated with higher post-transplant mortality and graft loss, yet those who decline may wait…
2020 American Transplant Congress
Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Rejection – Molecular Rebound Phenomena Under IL-6 Blockade?
A. Borski¹, S. Haindl², M. Duerr³, K. Budde³, S. Schranz¹, F. A. Eskandary², K. Doberer², P. F. Halloran⁴, E. Chong⁵, B. Jilma¹, G. A. Böhmig², M. Wahrmann²
¹Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Vitaeris Inc., Vancouver, BC, Canada
*Purpose: Late antibody-mediated rejection (ABMR) is well established as a major cause of kidney allograft failure. Targeting interleukin-6 (IL-6), a pro-inflammatory cytokine involved in B…
2020 American Transplant Congress
Multi- National Survey among Nephrologists & Transplant Surgeons about the Suitability and Acceptance of the Marginal Live Kidney Donors with Mild Hypertension
Z. Arabi¹, E. Elhassan¹, A. Altheaby¹, A. Hamad², S. Kaysi³
¹KAMC, Riyadh, Saudi Arabia, ²The Regional Medical Center, Orangeburg, SC, ³CHR Orleans, Orleans, France
*Purpose: There is variability among transplant centers in the acceptance of living donor candidates with well-controlled hypertension. Increased gestational hypertension and preeclampsia are more common…
2020 American Transplant Congress
New Everolimus Administration Targeting the Prevention of the Development of Antibody-Mediated Rejection Considering the Comparison of Growth and Survival in IgG and IgM Memory B Cells
Y. Matsuda¹, R. Imamura¹, H. Tezuka², S. Takahara¹
¹Osaka University Graduate School of Medicine, Suita, Japan, ²Fujita Health University, Toyoake, Japan
*Purpose: Some reports indicated that immunoglobulin (Ig) M antibodies corresponding to donor-specific antigen in addition to IgG antibodies are closely involved in the activation of…
2020 American Transplant Congress
Incidence and Outcomes of Secondary Cutaneous Malignancies among Renal Transplant Recipients
T. Maw¹, P. Vaidya¹, J. Samaan², S. Ghanshani¹, G. In¹
¹Keck School of Medicine, LA, CA, ²Cedar Sinai Hospital, LA, CA
*Purpose: Solid-organ transplant recipients on immunosuppressive therapy are known to have higher morbidity and mortality from secondary malignancies; however, there are no established guidelines for…
2020 American Transplant Congress
The Accuracy of the ICD-10 Diagnostic Codes for Kidney Transplant Rejection and Failure
D. Massicotte-Azarniouch¹, M. Sood², D. Fergusson³, M. Chassé⁴, A. Tinmouth⁵, G. Knoll²
¹Medicine, University of Ottawa, Ottawa Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ³Clinical Epidemiology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Medicine, University of Montreal, Ottawa, ON, Canada, ⁵Hematology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada
*Purpose: Clinical research requires that diagnostic codes captured from routinely collected health administrative data accurately identify individuals with a disease. In this study, we examined…
2020 American Transplant Congress
Low Food Security in Inner-City Kidney Transplant Recipients is Associated with Worse Graft Function, Lower Fruit and Vegetable Intake and Increased Psychosocial Stress
E. Kasparov, K. Cruickshank, A. Saleh, S. Pak, M. Markell
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Long-term kidney graft survival may be affected by factors other than biologic, including social determinants of health. We examined the association of the use…