Articles tagged "Islets"

2021 American Transplant Congress
Donor Mhc-independent Islet Rejection in Autoimmune Diabetes: Implications for Stem Cell Therapy
R. G. Gill¹, M. Coulombe², K. S. Beard¹, A. L. Burrack³
¹University of Colorado, Aurora, CO, ²Surgery, University of Colorado, Aurora, CO, ³Mircrobiology and Immunology, University of Minnesota, Minneapolis, MN
*Purpose: Stem cell technology is an attractive approach for generating insulin-producing cells for transplantation in insulin-dependent diabetes and potentially can be genetically modified. One recent…
2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky¹, D. Alagpulinsa¹, J. Lei², R. Pop³, D. Sobell⁴, M. Chapin¹, S. Collins³, A. Veres³, H. Deng², D. Melton³, J. Markmann²
¹Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, ²Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Stem Cell Institute, Harvard University, Cambridge, MA, ⁴Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
2020 American Transplant Congress
Circulating MicroRNA Signatures in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Transplantation
S. Vasu, C. M. Darden, K. Kumano, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by exocrine insufficiency and severe abdominal pain. Total pancreatectomy with islet autotransplantation (TPIAT) relieves chronic pain and aids restoration…
2020 American Transplant Congress
Immune Checkpoint PD-L1 Pathway as an Effective Platform for Localized Immunomodulation to Attain Indefinite Allogeneic Islet Graft Survival
L. Batra¹, P. Shrestha¹, H. Zhao¹, K. B. Woodward¹, M. Tan¹, O. G. Nuno¹, A. Togay¹, M. M. Coronel², A. J. Garcia², H. Shirwan¹, E. S. Yolcu¹
¹Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY, ²Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA
*Purpose: Allogenic islet transplantation is an effective therapeutic approach for the treatment of T1D. However, chronic immunosuppression to control rejection is a major limitation. The…
2020 American Transplant Congress
Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model
G. Yoshimatsu, T. Matsuoka, K. Chinen, N. Sakata, S. Kodama
Department of Regenerative Medicine and Transplantation, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
*Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…
2020 American Transplant Congress
Generation and Long-Term Culturing of AIPCs for Islet Replacement
J. B. Pollett¹, R. Bottino², S. Bertera², M. Trucco², N. Thai²
¹Imagine Pharma, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
*Purpose: Islet transplantation is one of the most promising hopes for a cure for type 1 diabetes, although islet shortage remains a serious concern. A…
2020 American Transplant Congress
AIPCs Home to and Engraft in the Pancreas When Injected Intravenously
J. B. Pollett¹, N. Thai²
¹Imagine Pharma, Pittsburgh, PA, ²Allegheny Health Network, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells) are a recently developed cell population generated from isolated islets of mice and humans. AIPCs are over 65% CD133-,…
2020 American Transplant Congress
Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks
R. A. Naqvi¹, W. Zhang¹, A. Isidan¹, C. Evans-Molina², J. A. Fridell¹, P. Li¹, B. Ekser¹
¹Division of Transplant Surgery, Indiana University, Indianapolis, IN, ²Diabetes Research Center, Indiana University, Indianapolis, IN
*Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…
2020 American Transplant Congress
Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma
K. Chinen, G. Yoshimatsu, N. Sakata, S. Kodama
Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan
*Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…
2020 American Transplant Congress
Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes
C. M. Darden¹, S. Vasu², K. Kumano¹, Y. Liu², P. Saravanan³, B. Naziruddin², M. Lawrence²
¹Institute of Biomedical Studies, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX, ³Transplant Surgery Department, VCU, Richmond, VA
*Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…

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