Articles tagged "Islets"

2016 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation for Chronic Pancreatitis: Considerations for Early Intervention.
J. Jolissaint,¹ L. Langman,¹ C. DeBolt,¹ A. Wang,² D. Strand,² V. Zaydfudim,¹ R. Adams,¹ K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Medicine, University of Virginia, Charlottesville, VA.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) provides pain relief for patients with chronic pancreatitis (CP) and the potential to ameliorate the resulting endocrine insufficiency.…
2016 American Transplant Congress
High Resolution Detection of Human Pancreatic Islet Damage During and After Isolation Procedure Using MicroRNAs.
S. Prathab Balaji,¹ M. Kanak,² G. Yoshimatsu,¹ C. Chang,¹ M. Levy,² M. Lawrence,¹ P. Kim,³ N. Onaca,³ B. Naziruddin.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX.
Background: Pancreatic islets are subjected to stresses throughout isolation procedures that account for considerable variation in quality and yield. Multiparameter methods are needed to monitor…
2016 American Transplant Congress
Isolating High Islet Mass Even from Alcoholic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation: Improved Strategies to Human Islet Isolation Technique.
A. Balamurugan, G. Loganathan, B. Tweed, W. Tucker, S. Mokshagundam, S. Williams, M. Hughes.
Surgery, Clinical Islet Cell Laboratory, Cardiovascular Innovation Insitute, Louisville, KY.
It has been reported in the literature that after pancreatic resection with planned islet auto-transplantation (IAT), islets isolated from alcoholic pancreatitis (AP) pancreases resulted in…
2016 American Transplant Congress
IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.
P. Chhabra, R. Gehrau, V. Mas, D. Bower, D. Maluf, K. Brayman.
UVA, Charlottesville.
Type 1 Diabetes (T1D) is hallmarked by beta-cells destruction. We aimed to identify specific pancreatic microRNAs (miRNA) as potential biomarkers for T1D prediction and diagnosis,…
2016 American Transplant Congress
Risk Factors for Early Readmission After Total Pancreatectomy with Islet Auto Transplantation.
R. Shahbazov,¹ N. Bashoo,² G. Yoshimatsu,² G. Saracino,² F. Azari,¹ N. Onaca,² P. Kim,² M. Levy.³
¹Charles O.Strikler Transplant Center, Department of Surgery, University of Virginia, Charlottesville, VA; ²Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX; ³Transplant Division, Virginia Commonwealth University, Richmond, VA.
Introduction: Readmission after Total Pancreatectomy with Islet Auto Transplantation (TPIAT) is common, but no data is available on reasons for readmission and islet graft function.Aims:…
2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba²⁺-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
M. Bochenek,¹ J. McGarrigle,¹ J. Mendoza-Elias,¹ E. Marchese,¹ M. Nourmohammadzadeh,¹ Y. Wang,¹ A. Khan,¹ M. Omami,¹ C.-C. Yeh,¹ I. Lacik,² B. Strand,³ J. Oberholzer.¹
¹Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; ²Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); ³Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
2016 American Transplant Congress
Comparison of Outcomes from Patients with Completion versus Total Pancreatectomy with Islet Autotransplantation: A Single-Institution Experience with 120 Consecutive Cases.
G. Yoshimatsu,¹ M. Takita,¹ R. Shahbazov,² M. Lawrence,¹ B. Naziruddin,³ P. Kim,³ M. Levy,⁴ N. Onaca.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Department of Surgery, University of Virginia, Charlottesville, VA; ³Transplant Division, VCU Medical Center, Richmond, VA; ⁴Baylor Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy (TP) or completion pancreatectomy is considered to effectively eliminate the severe pain from refractory chronic pancreatitis, if prior procedures failed. Islet autotransplantation…
2016 American Transplant Congress
Comparison of Early Engraftment Immunobiology of Xenoislets and Alloislets in a Dual Transplant Model.
K. Samy,¹ B. Martin,² M. Song,¹ B. Collins,¹ E. Gall,¹ J. Cano,² A. Farris,² F. Leopardi,¹ A. Kirk.^1,2
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory University, Atlanta, GA.
Purpose: Successful implementation of neonatal porcine islet (NPI) xenotransplantation requires an understanding of the xenospecific immune elements influencing engraftment. To elucidate these early xenospecific processes,…
2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
H. Ono,¹ Y. Asahi,¹ T. Yoshida,¹ Y. Koshizuka,¹ M. Watanabe,¹ U. Tomaru,² S. Emoto,¹ M. Fukai,³ A. Taketomi,¹ S. Todo,⁴ K. Yamashita.³
¹Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ²Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ³Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ⁴St Mary's Hospital, Kurume, Japan.
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
2015 American Transplant Congress
Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model
K. Samy,¹ B. Martin,² P. Thompson,² A. Farris,² M. Song,² V. Leopardi,¹ B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory Transplant Center, Emory University, Atlanta, GA.
Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…