ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Low Risk of Cytomegalovirus (CMV) Transmission in Clinical Islet Transplantation.

D. Kabbani,1 K. Cheung,2 P. Senior,2 C. Cervera,1 K. Doucette,1 J. Preiksaitis.1

1Infectious Diseases, University of Alberta, Edmonton, AB, Canada
2Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.

Meeting: 2016 American Transplant Congress

Abstract number: A77

Keywords: Cytomeglovirus, Islets

Session Information

Date: Saturday, June 11, 2016

Session Name: Poster Session A: Clinical Pancreas Transplantation and All Islet Cell Transplantation Topics

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Halls C&D

Related Abstracts
  • Donor Derived Transmission Events in 2014: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
  • Kinetics of Cytomegalovirus Load in Kidney Transplant Recipients Receiving Everolimus or Mycophenolate Sodium and No Pharmacological Prophylaxis.

Background:In solid organ transplantation (SOT), CMV is commonly transmitted from seropositive organ donors (D+) to seronegative recipients (R-), despite the use of antiviral prophylaxis. The epidemiology of CMV transmission in islet transplantation (IT) is not well defined.

Methods:This is a single center retrospective review of IT recipients at the University of Alberta Hospital transplanted from March 1999 to May 2014. Antiviral prophylaxis with ganciclovir or valganciclovir was given for 3 months for all D+/R- and CMV seropositive recipients (R+) that received antilymphocyte globulin (ALG) induction with alemtuzumab or thymoglobulin. R+ recipients without ALG induction received pre-emptive therapy. Outcomes assessed included CMV seroconversion and viremia.

Results:We analyzed 100 patients (63 CMV R-, 37 CMV R +) receiving 256 IT (mean 2.56 transplants per patient). Out of 256 transplants, 154 were performed in CMV R-, 98 in CMV R+ patients, and in 4 cases the serology was unknown or indeterminate. Out of the 154 CMV R, 77 had at least 1 CMV D+ and 77 had exclusively CMV D-. The islets were obtained from a single donor in 240 IT, 2 donors in 15 and 3 donors in 1 case. Seroconversion was documented in 7 patients in the follow-up (11%) of R- recipients. Seroconversion occurred at a median of 1,292 days after the last transplant (IQR 490.5-1733.5) in these 7 patients; 6 of them receiving IT from a single CMV D+ and 1 from a single CMV D-. Only 1 D+/R- patient had seroconversion within 1 year of transplant, 2 within 2 years and 3 beyond 2 years of transplantation making community acquired CMV more likely than islet transmission. Of the 100 patients analyzed, 72 had CMV viral load monitored post-transplant. Viremia was detected in 5 of 37 (14%) of CMV R+ and in 3 of 60 (5%) CMV R- (p=0.253). Three (of 7 patients) who had seroconversion, also had detectable CMV viral load. Only 4 patients had at least one CMV viral load higher than 1,000 IU/ml and 3 of them were CMV R- pre-transplant with seroconversion.

Conclusion:CMV seroconversion rates in CMV D+/R- islet transplants are low compared to SOT. The majority of seroconversion occurred beyond 1 year after IT suggesting community exposure and making CMV transmission through islets less likely. Our findings support a pre-emptive approach to CMV in R- islet transplants receiving islet transfusion from CMV D+ rather than universal prophylaxis.

CITATION INFORMATION: Kabbani D, Cheung K, Senior P, Cervera C, Doucette K, Preiksaitis J. Low Risk of Cytomegalovirus (CMV) Transmission in Clinical Islet Transplantation. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Kabbani D, Cheung K, Senior P, Cervera C, Doucette K, Preiksaitis J. Low Risk of Cytomegalovirus (CMV) Transmission in Clinical Islet Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/low-risk-of-cytomegalovirus-cmv-transmission-in-clinical-islet-transplantation/. Accessed March 4, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.