2016 American Transplant Congress
IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.
Type 1 Diabetes (T1D) is hallmarked by beta-cells destruction. We aimed to identify specific pancreatic microRNAs (miRNA) as potential biomarkers for T1D prediction and diagnosis,…2016 American Transplant Congress
Risk Factors for Early Readmission After Total Pancreatectomy with Islet Auto Transplantation.
Introduction: Readmission after Total Pancreatectomy with Islet Auto Transplantation (TPIAT) is common, but no data is available on reasons for readmission and islet graft function.Aims:…2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba2+-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…2016 American Transplant Congress
Comparison of Outcomes from Patients with Completion versus Total Pancreatectomy with Islet Autotransplantation: A Single-Institution Experience with 120 Consecutive Cases.
Introduction: Total pancreatectomy (TP) or completion pancreatectomy is considered to effectively eliminate the severe pain from refractory chronic pancreatitis, if prior procedures failed. Islet autotransplantation…2016 American Transplant Congress
Comparison of Early Engraftment Immunobiology of Xenoislets and Alloislets in a Dual Transplant Model.
1Department of Surgery, Duke University Medical Center, Durham, NC; 2Emory University, Atlanta, GA.
Purpose: Successful implementation of neonatal porcine islet (NPI) xenotransplantation requires an understanding of the xenospecific immune elements influencing engraftment. To elucidate these early xenospecific processes,…2016 American Transplant Congress
Effect of Pylorus Preservation Procedure on Patient and Graft Outcome in Total Pancreatectomy with Islet Autotransplantation.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment to retain pancreatic endocrine function while alleviating intractable pain in Chronic Pancreatitis. The role…2016 American Transplant Congress
Pancreas After Islet Transplantation – A Successful Treatment Option After a Failed Islet Transplant.
Department of Surgery, SUNY Upstate Medical University, Syracuse, NY.
Introduction: Pancreas after islet (PAI) transplantation (tx) is a treatment option for patients seeking insulin independence through a whole organ transplant after a previous, failed…2016 American Transplant Congress
Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.
Background: Diabetes constitutes a significant problem in the transplant recipient. Diabetes is associated with impaired immunity to pathogens but its effect on alloimmunity remains ambiguous.…2016 American Transplant Congress
Enhanced IL-6 Production Impedes Transplant Tolerance Induction in Lupus-Prone Mice.
Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.
Significance: Autoimmunity is a significant barrier to transplantation. Based on previous studies, it is apparent that there are separate genetic regions that control susceptibility to…2016 American Transplant Congress
Long-Term Islet Xenograft Survival Requires Effective Control of Early Xenogeneic IL-17 Response and Late Xenogeneic IFN-γ Response.
Introduction: Tolerance induction for xenogeneic islet transplant remains a challenge. We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) is…
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