ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function.

J. Gołębiewska,1 J. Solomina,2 S. Matosz,2 C. Thomas,3 L. Schenck,2 K. Golab,2 W. Chon,3 S. Ramachandran,2 M. Tibudan,2 A. Dębska-ŚLizień,1 B. Rutkowski,1 P. Witkowski.2

1Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland
2Department of Surgery, University of Chicago, Chicago, IL
3Department of Medicine, University of Chicago, Chicago, IL.

Meeting: 2016 American Transplant Congress

Abstract number: A79

Keywords: Graft function, Islets, Outcome

Session Information

Date: Saturday, June 11, 2016

Session Name: Poster Session A: Clinical Pancreas Transplantation and All Islet Cell Transplantation Topics

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Halls C&D

Related Abstracts
  • Use of Continuous Glucose Monitoring (CGM) in the Evaluation of Auto-Islet Candidates
  • Association of IP-10 With Poor Islet Graft Function After Total Pancreatectomy With Islet Autotransplantation

Background: Mixed Meal Tolerance Test (MMTT) together with the beta-score are standard tools to evaluate beta-cell function after islet transplantation but utilization of the test might be challenging due to logistic barriers. The Secretory Unit of Islet Transplant Objects (SUITO) index can be calculated using only single fasting blood glucose and C-peptide levels. The C-peptide/glucose creatinine ratio (CP/GCr) also utilized the same values but is additionally adjusted for renal function.

Methods: Laboratory values from clinical evaluations in recipients of allogeneic islet grafts were analyzed at different times post-first islet infusion at 6-month intervals. We assessed correlation of CP/GCr and SUITO with the gold standard of peak serum glucose in MMTT and beta-score with using Spearman's rank correlation.

Results: We analyzed values from 42 MMTT tests in 4 long-term (LT group) recipients of allogeneic islet grafts with up to 126 months follow up as well as values from 28 MMTT tests in 12 patients with up to 2 year follow up (ST group). MMTT serum glucose was adversely correlated with both CP/GCr (r = -0.34 for LT and r=-0.44 for ST group, p<0.05) and SUITO (r = -0.61 for LT and r=-0.60 for ST, p<0.05). In addition, both SUITO and CP/GCr correlated with clinical outcomes as assessed by beta-score (r = 0.77, p<0.001 and r = 0.38, p=0.01, respectively). All 4 patients remained insulin free over 7 years but required 3 islet infusions as their graft function fluctuated over time. Both CP/GCr and SUITO were able to identify islets dysfunction. In ST group, 11 out of 12 patients are currently still insulin-free.

Conclusions: The ease of obtaining single fasting peripheral blood samples necessary for CP/GCr and SUITO calculation, as well as a good correlation of those indexes with other more logistically challenging tests makes them a very practical alternative tool for monitoring and managing islet transplant recipients in our center.

CITATION INFORMATION: Gołębiewska J, Solomina J, Matosz S, Thomas C, Schenck L, Golab K, Chon W, Ramachandran S, Tibudan M, Dębska-ŚLizień A, Rutkowski B, Witkowski P. Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Gołębiewska J, Solomina J, Matosz S, Thomas C, Schenck L, Golab K, Chon W, Ramachandran S, Tibudan M, Dębska-ŚLizień A, Rutkowski B, Witkowski P. Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/validation-of-suito-index-and-c-peptideglucose-creatinine-ratio-as-convenient-tools-for-the-evaluation-of-the-short-and-long-term-islet-allograft-function/. Accessed March 6, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Role of Mitochondria, Metabolism and Inflammation: Pathways Influencing Short Term Outcomes Post-Renal Transplantation
    • Factors Influencing Creatinine Rise Following Donor Nephrectomy

    Visit Our Partner Sites

    American Transplant Congress (ATC)

    Visit the official site for the American Transplant Congress »

    American Journal of Transplantation

    The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

    American Society of Transplantation (AST)

    An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

    American Society of Transplant Surgeons (ASTS)

    The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

    Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

    Privacy Policy

    loading Cancel
    Post was not sent - check your email addresses!
    Email check failed, please try again
    Sorry, your blog cannot share posts by email.
    This site uses cookies: Find out more.