Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function.
1Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland
2Department of Surgery, University of Chicago, Chicago, IL
3Department of Medicine, University of Chicago, Chicago, IL.
Meeting: 2016 American Transplant Congress
Abstract number: A79
Keywords: Graft function, Islets, Outcome
Session Information
Date: Saturday, June 11, 2016
Session Name: Poster Session A: Clinical Pancreas Transplantation and All Islet Cell Transplantation Topics
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background: Mixed Meal Tolerance Test (MMTT) together with the beta-score are standard tools to evaluate beta-cell function after islet transplantation but utilization of the test might be challenging due to logistic barriers. The Secretory Unit of Islet Transplant Objects (SUITO) index can be calculated using only single fasting blood glucose and C-peptide levels. The C-peptide/glucose creatinine ratio (CP/GCr) also utilized the same values but is additionally adjusted for renal function.
Methods: Laboratory values from clinical evaluations in recipients of allogeneic islet grafts were analyzed at different times post-first islet infusion at 6-month intervals. We assessed correlation of CP/GCr and SUITO with the gold standard of peak serum glucose in MMTT and beta-score with using Spearman's rank correlation.
Results: We analyzed values from 42 MMTT tests in 4 long-term (LT group) recipients of allogeneic islet grafts with up to 126 months follow up as well as values from 28 MMTT tests in 12 patients with up to 2 year follow up (ST group). MMTT serum glucose was adversely correlated with both CP/GCr (r = -0.34 for LT and r=-0.44 for ST group, p<0.05) and SUITO (r = -0.61 for LT and r=-0.60 for ST, p<0.05). In addition, both SUITO and CP/GCr correlated with clinical outcomes as assessed by beta-score (r = 0.77, p<0.001 and r = 0.38, p=0.01, respectively). All 4 patients remained insulin free over 7 years but required 3 islet infusions as their graft function fluctuated over time. Both CP/GCr and SUITO were able to identify islets dysfunction. In ST group, 11 out of 12 patients are currently still insulin-free.
Conclusions: The ease of obtaining single fasting peripheral blood samples necessary for CP/GCr and SUITO calculation, as well as a good correlation of those indexes with other more logistically challenging tests makes them a very practical alternative tool for monitoring and managing islet transplant recipients in our center.
CITATION INFORMATION: Gołębiewska J, Solomina J, Matosz S, Thomas C, Schenck L, Golab K, Chon W, Ramachandran S, Tibudan M, Dębska-ŚLizień A, Rutkowski B, Witkowski P. Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Gołębiewska J, Solomina J, Matosz S, Thomas C, Schenck L, Golab K, Chon W, Ramachandran S, Tibudan M, Dębska-ŚLizień A, Rutkowski B, Witkowski P. Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/validation-of-suito-index-and-c-peptideglucose-creatinine-ratio-as-convenient-tools-for-the-evaluation-of-the-short-and-long-term-islet-allograft-function/. Accessed March 6, 2021.« Back to 2016 American Transplant Congress