2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…2022 American Transplant Congress
Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
*Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel…2022 American Transplant Congress
Spleen-Preserving Total Pancreatectomy with Islet Autotransplantation with Complete Preservation of the Splenic Arterial and Venous Supply Does Not Impact Islet Yield and Function
Baylor University Medical Center, Dallas, TX
*Purpose: Typically, Total Pancreatectomy with Islet Autotransplantation (TPIAT) includes splenectomy. Spleen sparing TPIAT was described in the literature using the Warshaw technique, with proximal ligation…2022 American Transplant Congress
The Application of Activated Stem Cells from Human Exfoliated Deciduous Teeth (SHED) in Islet Transplantation for Novel Immunosuppressive Therapy
*Purpose: While various attempts have been made to improve the efficiency of islet transplantation, we have been working on the analysis of the mechanism of…2022 American Transplant Congress
Biological Functions of Circulating miRNAs in Patients with Chronic Pancreatitis Undergoing Total Pancreatectomy with Islet Autotransplantation
*Purpose: Our previous reports showed that in patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after…2022 American Transplant Congress
Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes
*Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…2022 American Transplant Congress
Evidence for Improved Quality of Life Among Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation Using EORTC QLQ-C30 and QLQ-PAN 26
Baylor University Medical Center, Dallas, TX
*Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is the treatment of choice to preserve endocrine function, alleviate pain, reduce or eliminate chronic narcotic use and…2022 American Transplant Congress
Pegylated Lacritin N-104 Promotes Mouse Islet Stabilization and Prevents Diabetes Progression in the Non-Obese Diabetic (NOD) Mouse Model
*Purpose: To investigate if PEGylated Lacritin N-104 (PEG N-104) prevents the progression of type 1 diabetes (T1D) in the NOD mouse.*Background: Lacritin is a multifunctional…2022 American Transplant Congress
Generation Of Insulin Producing Cells From Pancreatic Tissue With Long Standing Type 1 Diabetes
Imagine Pharma, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells), are a novel cell population from isolated human islets obtained using a simple culture protocol that can generate cells…2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
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