Articles tagged "Inflammation"

2021 American Transplant Congress
Biomarkers of Kidney Injury and Repair in Expanded-Criteria Deceased Donor Kidney Transplant Recipients: A Prospective Study
A. Al Jurdi¹, O. Efe¹, B. Aoyama², M. Lima², H. Silva², I. Schmidt³, S. Waikar³, V. Sabbisetti⁴, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil, ³Boston Medical Center, Boston, MA, ⁴Brigham and Women’s Hospital, Boston, MA
*Purpose: Expanded-criteria donor (ECD) kidney transplants are at higher risk of kidney injury. Biomarkers that better predict short and long-term outcomes in ECD kidney transplant…
2021 American Transplant Congress
Galectin-3 Levels in Pediatric Cholestatic Liver Disease
D. Yoeli¹, Z. Wang¹, Y. Luo², A. Chaidez², M. A. Adams¹, C. A. Huang¹, C. L. Mack², N. Navarro Alvarez¹
¹Transplant Surgery, University of Colorado, Aurora, CO, ²Pediatric Gastroenterology, Hepatology and Nutrition, Children’s Hospital Colorado, Aurora, CO
*Purpose: Biliary atresia (BA) and other cholestatic liver diseases (CLD) are the most common indications for liver transplantation in children. Research on galectin-3, a protein…
2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
J. Kang¹, L. Belyayev¹, O. Aguirre¹, K. Khan¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom³, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, ³Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…
2021 American Transplant Congress
Novel Morphologic Biomarkers of Cardiac Allograft Remodeling are Associated with Multiple Peri- and Post-transplant Inflammatory Processes
C. Yuan¹, S. Arabyarmohammadi¹, H. Li¹, E. Peyster², P. Lal³, M. Feldman³, K. Margulies², A. Madabhushi¹
¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, ²Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: It has long been recognized that transplanted hearts develop a stiffened, restrictive physiology at an accelerated rate compared to native hearts. While this is…
2021 American Transplant Congress
Core Signature of Rejection-Specific Cytokines and Chemokines in Heart Biopsies After Transplantation
L. M. Radomsky¹, Y. Scheibner², J. F. Kuehne¹, J. Keil¹, K. Beushausen¹, K. Ludmilla², A. Schick², F. Ius², G. Warnecke³, C. Bara², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Clinic for Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
*Purpose: Allograft rejection remains one of the limiting factors for survival after HTX. The aim of this project was to characterize the cytokine/chemokine network in…
2021 American Transplant Congress
Adjuvant Treatment Shapes the Bone Marrow Myeloid Compartment Towards an Immunosuppressive Phenotype That Can Suppress Allograft Rejection
J. Ge¹, E. Anderson¹, J. F. Markmann², A. Cuenca¹
¹Surgery, Boston Children's Hospital, Boston, MA, ²Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) expand in response to inflammatory stimuli and have been shown to suppress adaptive immunity. Preliminary data from our lab…
2021 American Transplant Congress
Clinically Evident Portal Hypertension (CEPH) is Associated with Low IGF-1 in Children with Chronic Liver Disease
B. Whitehead¹, S. Mohammad¹, S. Kelly¹, J. Josefson², L. Mithal³, E. M. Alonso¹
¹Division of Gastroenterology, Hepatology and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ²Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ³Division of Infectious Disease, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
*Purpose: Children with chronic liver disease exhibit growth hormone resistance which is an additional risk factor for sarcopenia and growth failure in this vulnerable population.…
2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
A. Dangi¹, S. Yu², I. Husain¹, R. Geesala¹, X. Luo¹
¹Nephrology, Medicine, Duke University, Durham, NC, ²Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
2021 American Transplant Congress
Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma
E. Chichelnitskiy¹, B. Wiegmann², N. Ledwoch¹, F. Ius², F. Wandrer¹, J. Kühne¹, K. Beushausen¹, J. Keil¹, S. V. Rojas², W. Sommer², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany
*Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…
2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…

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