2020 American Transplant Congress
Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation
*Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…2020 American Transplant Congress
Nlrp3 Inhibition Improves Heart Graft Function in Donation after Circulatory Death
Virginia Commonwealth University, Richmond, VA
*Purpose: Donation after circulatory death (DCD) donors have the potential to increase the number of transplantable hearts, which today relies only on donation after brain…2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…2020 American Transplant Congress
Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury
*Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…2020 American Transplant Congress
IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions
*Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…2020 American Transplant Congress
Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model
*Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…2020 American Transplant Congress
DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions
*Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…2020 American Transplant Congress
Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection
Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…
American Transplant Congress abstracts