Articles tagged "Inflammation"

2018 American Transplant Congress
Early Blockade of Toll-Like Receptor 4 Reduces Ischemia-Reperfusion Injury and Improves Islet Transplantation Outcomes
C. Chang,¹ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco; ²Baylor Scott & White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Purpose: Inflammatory damage to islets during isolation is a major hurdle for success in transplantation. We investigated the safety and therapeutic potential of pharmacological blockade…
2018 American Transplant Congress
Dialysis Modality, Inflammation, and Frailty in Kidney Transplant Candidates
P. Shrestha, H. Ying, M. McAdams DeMarco, D. Segev.
JHU, Baltimore, MD.
Inflammation is associated with poor physical performance, frailty, disability and death in community-dwelling older adults. Given the elevated inflammation levels among ESRD patients, it is…
2018 American Transplant Congress
Incidence of Pneumonitis in Heart Transplant Patients Started on a Proliferation Signal Inhibitor
R. Levine, J. Patel, M. Levine, M. Kittleson, E. Kransdorf, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Proliferation signal inhibitors(PSI) have a high discontinuation rate due to side effects. PSI induced pneumonitis has been reported in 14% in renal cell carcinoma…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…
2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹
¹Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ²Division of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; ³Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Hokkaido, Japan.
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…
2018 American Transplant Congress
Frailty, Inflammation, and Waitlist Mortality among Patients with End-Stage Renal Disease
M. McAdams DeMarco,¹ H. Ying,¹ A. Thomas,¹ F. Warsame,¹ A. Shaffer,¹ C. Haugen,¹ J. Garonzik Wang,¹ N. Desai,¹ S. Norman,² D. Segev.¹
¹JHU, Baltimore; ²UMich, Ann Arbor.
Background: Among older adults, frailty is associated with heightened inflammation and subsequent mortality. Although frailty is common among patients on the KT waitlist, the role…
2018 American Transplant Congress
NFkB Inhibitor Improves Glycemic Control after Syngeneic Islet Transplantation by Suppression of Proinflammatory and Apoptotic Gene Expression in a Cerulein-Induced Pancreatitis Model
G. Yoshimatsu,¹ C. Darden,² K. Kumano,² C. Chang,² P. Saravanan,² M. Lawrence,² B. Naziruddin.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. Repeated or continuous pancreatitis attack leads islet damage beyond inflamed exocrine…
2018 American Transplant Congress
Assessment of Immune Cell Profiles in HLA-Sensitized (HS) & Non-HS Patients (Pts) with End Stage Renal Disease (ESRD)
S. Ge,¹ M. Chu,¹ E. Ortiz,¹ A. Vo,² D. Lovato,¹ S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Chronic inflammation is often seen in pts w/ ESRD. HLA-sensitization may create or be driven by the cytokines responsible for chronic inflammation. Here we…
2018 American Transplant Congress
Components of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBX) Impacting Late Death Censored Graft Failure (DCGF)
J. Grande,¹ L. Hunsicker,² R. LeDuc,³ A. Matas,³ The DeKAF Consortium.
¹Pathology, Mayo Clinic, Rochester, MN; ²Int. Med., U Iowa, Iowa City, IA; ³Biostatistics and Surgery, U Minnesota, Minneapolis, MN.
Recent studies document that MVI increases DCGF. However, the relationship between components of MVI (Banff scores g, cg, ptc) and macrovascular inflammation (v) have not…
2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
P. Saravanan,¹ G. Yoshimatsu,¹ R. Bhattacharjee,¹ C. Chang,¹ C. Darden,¹ B. Naziruddin,² M. Lawrence.¹
¹Islet Cell Lab, Baylor Scott & White Research Institute, Dallas, TX; ²Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…