2016 American Transplant Congress
Th17 Development Is Critical for Airway Epithelial Injury After Transplantation.
Department of Immunology, Capital Medical University, Beijing, China.
Background: Development of obliterative bronchiolitis (OB) is the biggest obstacle that limits long-term allograft survival and clinical application of lung transplantation, and the precise mechanisms…2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…2016 American Transplant Congress
Acute Inflammation, Chronic Damage and Renal Dysfunction in Renal Transplant Recipients with Delayed Graft Function (DGF).
Analysis of DGF and clinical outcomes in relation to progressive histological changes is not well reported. In this prospective longitudinal study, patients with DGF were…2016 American Transplant Congress
Donor Sharpin Expression Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
Increased systemic TNFα levels correlate with transplant rejection and severity of GVHD, and TNFα blockade can prolong graft survival and reduce severity of GVHD. These…2016 American Transplant Congress
Activation of Innate Immunity During Human OLT-IRI Triggers Adaptive Immunity and Correlates with the Degree of IRI Injury.
1Surgery, Dumont-UCLA Transplant Ctr, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
Ischemia reperfusion injury (IRI) in orthotopic liver transplantation (OLT) can severely compromise graft and recipient survival. We postulate this is mediated by interactions between the…2016 American Transplant Congress
A Systematic Over View of Five Year Results of Serial Protocol Kidney Transplant Biopsies.
Surgery, UCSF, San Francisco, CA.
Background: Protocol biopsies can detect sub-clinical rejection. With declining rates of clinical acute rejection, a systematic review of protocol biopsies can provide clues about other…2016 American Transplant Congress
Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.
Surgery, Duke University Medical Center, Durham, NC.
Vascular endothelial cells (ECs) are an initial barrier between allografts and the host immune system and play an important role in initiating allograft rejection. Increasing…2016 American Transplant Congress
Re-Examining the Role of B-1 Cells in a Murine Model of Renal Ischemia Reperfusion Injury.
We propose a reexamination of the currently underappreciated role of B-1 cells in IRI. Ischemia reperfusion injury (IRI) is a two phase insult composed of…2016 American Transplant Congress
Fecal Microbiota Transplant Results in Durable Changes to Host Microbiota That Correlate with Allograft Outcome.
CVID and IGS, University of Maryland School of Medicine, Baltimore, MD.
Hypothesis: We previously presented highly significant differences in the bacterial community structures of human renal allograft recipients over time. Likewise, murine normal, colitic, and pregnant…2016 American Transplant Congress
B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.
*Equal contributionPurposeVascularized composite allotransplantation (VCA) is a promising new field in plastic surgery. Skin is known to be the most immunogenic component of a composite…
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