Articles tagged "Inflammation"

2016 American Transplant Congress
Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.
M. Lo Faro,¹ M. Akhtar,¹ H. Huang,¹ M. Kaisar,¹ R. Robolledo,² K. Morten,¹ L. Heather,¹ A. Dona,³ H. Leuvenink,² S. Fuggle,¹ B. Kessler,¹ C. Pugh,¹ R. Ploeg.¹
¹University of Oxford, Oxford, United Kingdom; ²University of Groningen, Groningen, Netherlands; ³University of Sydney, Sydney, Australia.
Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…
2016 American Transplant Congress
Effect of Inflammation on Concentration of Intracellular Tacrolimus.
E. Bae,¹ S. Yang,² S. Han,¹ J.-Y. Park,¹ H. Lee,¹ Y. Kim.¹
¹Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Kidney Research Institute, Seoul National University, Seoul, Republic of Korea.
Background: The use of calcineurin inhibitors improved the outcome for transplant recipients. However, acute rejection (AR) and infection remained still an unsolved problem. We evaluated…
2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
R. Finnegan,¹ P. Zhu,¹ S. Stephenson,¹ K. Patel,² S. Nadig,^1,2,3 C. Atkinson.^1,2,3
¹Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC; ³South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
2016 American Transplant Congress
The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.
T. Sigdel,¹ T. Tran,¹ O. Bestard,² F. Vincenti,¹ M. Sarwal.¹
¹Surgery, UCSF, San Francisco, CA; ²Nephrology, Bellevitage Hospital, Barcelona, Spain.
Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…
2016 American Transplant Congress
Serial Peripheral Blood Mononuclear Cell Expression Profiling Reveals Inflammatory Genomic Storm Following Mechanical Circulatory Support Surgery.
G. Godoy,¹ G. Bondar,¹ A. Esmaeili,¹ E. Arellano,¹ E. Chang,¹ M. Bakir,¹ J. Chittoor,¹ R. Togashi,¹ N. Fazli,¹ C. Starling,¹ E. Oh,¹ S. Toluie,¹ Z. Yang,² D. Tran,¹ M. Cadeiras,¹ N. Wisniewski,¹ M. Kwon,¹ J. Schaenman,¹ Y. Korin,¹ M. Rosetti,¹ E. Reed,¹ M. Deng.¹
¹University of California, Los Angeles, Los Angeles, CA; ²Shanxi Medical University First Hospital, Taiyuan, Shanxi, China.
Introduction: The main cause of death in patients with Advanced Heart Failure (AdHF) is the Multi-Organ Dysfunction (MOD) Syndrome. Immune system aberrancy after Mechanical Circulatory…
2016 American Transplant Congress
Early Alloantibody Responses Against Donor MHC Class I and Class II Molecules Are Differentially Affected by Prolonged Cold Ischemia Storage of Renal Allografts.
V. Gorbacheva, R. Fan, W. Baldwin, A. Valujskikh.
Immunology, Cleveland Clinic Foundation, Cleveland, OH.
Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury. Despite strong clinical correlations between…
2016 American Transplant Congress
Serum Inflammatory Biomarkers in Kidney Transplant Recipients and Renal Donors.
J. Ramirez,¹ E. Cuevas,¹ J. Furuzawa,² L. Morales-Buenrostro,³ M. Lopez-Cervantes,² J. Alberu.¹
¹Transplantation, Inst Nal Ciencia Medicas y Nutricion SZ, Mexico City, Mexico; ²Immunology, Inst Nal Ciencia Medicas y Nutricion SZ, Mexico City, Mexico; ³Nephrology, Inst Nal Ciencia Medicas y Nutricion SZ, Mexico City, Mexico; ⁴Medicine School, UNAM, Mexico City, Mexico.
Kidney transplant recipients (KTR) have an increased risk for cardiovascular events, graft failure, and death. It is unknown whether serum inflammatory biomarkers correlate with eGFR…
2016 American Transplant Congress
Recombinant TSGL-Ig Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation.
C. Zhang,^1,2 H. Ji,¹ Y. Liu,^1,2 Y. Zhang,^1,2 X.-D. Shen,¹ F. Gao,¹ R. Busuttil, G. Shaw, J. Kupiec-Weglinski.
¹Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA; ²Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Background: Liver endothelial cells (LEC) suffer from ROS-mediated stress in the pathogenesis of liver ischemia-reperfusion injury (IRI). We used a novel recombinant form of soluble…
2016 American Transplant Congress
Primary Graft Failure following Cardiac Transplantation Is Associated with Elevated Pre-Transplant Levels of Pro-Inflammatory Factors.
D. Chatterjee,¹ K. Clerkin,¹ K. Rogers,¹ D. Mancini,¹ Y. Naka,¹ H. Takayama,² K. Takeda,² P. Colombo,² G. Vlad,³ R. Vasilescu,³ B. Levin,⁴ M. Farr,¹ S. Restaino,¹ E. Zorn.¹
¹Columbia University Medical Center, NY; ²Surgery, Columbia University Medical Center, NY; ³Pathology & Cell Biology, Columbia University Medical Center, NY; ⁴Biostatistics, Columbia University Medical Center, NY.
Primary graft failure (PGF) is defined as severe ventricular dysfunction immediately following heart transplantation (HTx) requiring temporary mechanical circulatory support (MCS) such as VA ECMO…