Articles tagged "Inflammation"

2017 American Transplant Congress
Ischemia Reperfusion Injury (IRI) Causes Local Release of Free Heme Which Aggravates Inflammation and Contributes to Delayed Graft Function.
F. Gueler,¹ R. Chen,¹ A. Thorenz,¹ K. Madyaningrana,² J. Bräsen,³ H. Haller,¹ S. Immenschuh,³ V. Vijayan.³
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Transfusion Medicine, Hannover Medical School, Hannover, Germany; ³Pathology, Hannover Medical School, Hannover, Germany
Ischemia reperfusion injury (IRI) is relevant in solid organ transplantation and contributes to delayed graft function (DGF). In this study, release of free heme after…
2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
M. Rossetti,¹ C. Fitzpatrick,¹ N. Harre,¹ Y. Zheng,¹ N. Mercer,² G. Sunga,¹ D. Gjertson,¹ E. Reed.¹
¹Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; ²Department of Biostatistics, University of California Los Angeles, Los Angeles, CA
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…
2016 American Transplant Congress
High Concentrations of CXCL9 and CXCL10 Chemokines but Not CXCL8 (IL-8), IL-6, TNF-a or IFN-g in Biopsy Tissue Are Associated with Pathological Staging of Rejection After Kidney Transplantation.
C. Falk,¹ C. Neudörfl,¹ K. Daemen,¹ J. Keil,¹ F. Lehner,² H. Haller,³ J. Schmitz,⁴ C. Blume,⁵ J.-H. Bräsen.⁴
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Abdominal and Transplantation Surgery, Hannover Medical School, Hannover, Deutschland, Germany; ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Deutschland, Germany; ⁴Institute of Pathology, Hannover Medical School, Hannover, Deutschland, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Deutschland, Germany.
Background: Extensive expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection, especially antibody-mediated rejection (AMR) can be defined by distinct signatures. Thus,…
2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.
D. Sadowsky, R. Zamora, B. Banan, D. Barclay, J. Yin, Y. Vodovotz, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…
2016 American Transplant Congress
Comparison of Early Engraftment Immunobiology of Xenoislets and Alloislets in a Dual Transplant Model.
K. Samy,¹ B. Martin,² M. Song,¹ B. Collins,¹ E. Gall,¹ J. Cano,² A. Farris,² F. Leopardi,¹ A. Kirk.^1,2
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory University, Atlanta, GA.
Purpose: Successful implementation of neonatal porcine islet (NPI) xenotransplantation requires an understanding of the xenospecific immune elements influencing engraftment. To elucidate these early xenospecific processes,…
2016 American Transplant Congress
Th17 Development Is Critical for Airway Epithelial Injury After Transplantation.
J. Xu, Y. Zhang, L. Wang, X. Li, R. Chen, R. Zhang, Y. Ding.
Department of Immunology, Capital Medical University, Beijing, China.
Background: Development of obliterative bronchiolitis (OB) is the biggest obstacle that limits long-term allograft survival and clinical application of lung transplantation, and the precise mechanisms…
2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…
2016 American Transplant Congress
Acute Inflammation, Chronic Damage and Renal Dysfunction in Renal Transplant Recipients with Delayed Graft Function (DGF).
A. Cherukuri, R. Mehta, P. Sood, P. Randhawa, A. Tevar, S. Hariharan.
UPMC, Pittsburgh.
Analysis of DGF and clinical outcomes in relation to progressive histological changes is not well reported. In this prospective longitudinal study, patients with DGF were…
2016 American Transplant Congress
Donor Sharpin Expression Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
R. Ang,¹ P. Heeger,² A. Ting.¹
¹Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY; ²Center for Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York City, NY.
Increased systemic TNFα levels correlate with transplant rejection and severity of GVHD, and TNFα blockade can prolong graft survival and reduce severity of GVHD. These…
2016 American Transplant Congress
Activation of Innate Immunity During Human OLT-IRI Triggers Adaptive Immunity and Correlates with the Degree of IRI Injury.
A. Zarrinpar,¹ R. Sosa,² P. Rao,² C. Lassman,² R. Busuttil,¹ D. Gjertson,² J. Kupiec-Weglinski,¹ E. Reed.²
¹Surgery, Dumont-UCLA Transplant Ctr, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Ischemia reperfusion injury (IRI) in orthotopic liver transplantation (OLT) can severely compromise graft and recipient survival. We postulate this is mediated by interactions between the…