Articles tagged "Inflammation"

2016 American Transplant Congress
Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.
L. Boneschansker,^1,2 D. Irimia,² D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston; ²MGH, Boston.
Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…
2016 American Transplant Congress
The Immunologic Profile of Brain Death in Humans: A Whole-Body Analysis.
D. Carpenter,^1,2 N. Matsuoka,¹ J. Thome,^1,3 T. Granot,^1,3 C. Gordon,^1,3 B. Kumar,^1,3 T. Senda,^1,3 M. Miron,^1,3 J. Weiner,² A. Griesemer,^1,2 D. Farber.^1,2,3
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York City, NY; ²Surgery, Columbia University Medical Center, New York City, NY; ³Microbiology and Immunology, Columbia University Medical Center, New York City, NY.
Transplantation outcomes are believed to be influenced by a generalized inflammatory state caused by brain death itself or events in the peri-transplant period. Studies on…
2016 American Transplant Congress
Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.
S. de Witte,¹ M. Franquesa,¹ T. Strini,¹ S. Korevaar,¹ F. Luk,¹ S. Elliman,² P. Newsome,³ M. Gargesha,⁴ D. Roy,⁴ A. Merino,¹ C. Baan,¹ M. Hoogduijn.¹
¹ErasmusMC, Rotterdam, Netherlands; ²Orbsen Therapeutics, Galway, Ireland; ³University of Birmingham, Birmingham, United Kingdom; ⁴Bioinvision, Mayfield Village.
Mesenchymal stromal cells (MSC) are candidates for immunotherapy after transplantation. MSC have shown to be immunomodulatory and low immunogenic, which is favorable for cellular therapy…
2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
M. Braza,¹ M. Lameijer,¹ C. Perez-Medina,¹ T. Reiner,³ M. Nahrendorf,⁴ Z. Fayad,¹ R. Duivenvoorden,¹ J. Ochando,² W. Mulder.¹
¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York; ²Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York; ³Radiology, Memorial Sloan-Kettering Cancer Center, New York; ⁴Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…
2016 American Transplant Congress
Liver Graft Steatosis Associates with an Increase of Circulating Immune Response Chemokines.
R. Gehrau, V. Mas, A. Sharma, V. Bontha, D. Maluf.
University of Virginia, Charlottesville.
Background: Liver graft steatosis, especially macrosteatosis induces severe graft injury post-liver transplantation (LT) by activating cell-mediated immunity and inflammation. This study aimed to determine differential…
2016 American Transplant Congress
The IFN-Gamma-Inducible Protein (IP-10/CXCL10) Is a Promising Target to Improve Endocrine Function Following Islet Transplantation.
G. Yoshimatsu,¹ M. Kanak,² P. Balaji S,¹ C. Chang,³ C. Darden,³ M. Takita,¹ M. Lawrence,¹ B. Naziruddin.⁴
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Transplant Services, Baylor Simmons Transplant Institute, Dallas, TX.
A significant mass of transplanted islets is lost very early due to an inflammatory reaction. CXCL10 is a chemokine that is highly expressed in islets…
2016 American Transplant Congress
Predictors of Early Rejection and Allograft Failure in Pediatric Kidney Transplantation: Impact of Histology and Behavior.
M. Seifert, M. Yanik, R. Mannon.
University of Alabama at Birmingham School of Medicine, Birmingham.
Background: Early inflammatory events that lead to allograft dysfunction are often missed by creatinine-based estimates in children. Surveillance biopsies can detect early allograft dysfunction due…
2016 American Transplant Congress
The Significance of Microvascular Inflammation in Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
H. Ishihara,¹ H. Ishida,¹ K. Unagami,² T. Hirai,¹ M. Okumi,¹ K. Omoto,¹ T. Shimizu,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical University, Tokyo, Japan.
Background: In ABO-incompatible (ABOi) transplantation, the criteria for antibody-mediated rejection (AMR) are controversial, as C4d deposition is common in ABOi. This study examined the impact…
2016 American Transplant Congress
NFκB Inhibitor Withaferin A Blocks IBMIR In Vitro: miRNA 375 Analysis.
M. Kanak,¹ M. Takita,² G. Yoshimatsu,² M. Lawrence,² M. Levy,¹ B. Naziruddin.³
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Islet Tranpsplant Lab, Baylor Research Institute, Dallas, TX; ³Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.
Background: Instant Blood Mediated Inflammatory Reaction (IBMIR) has been shown to severely affect islet engraftment. We previously reported that Withaferin A (WA) can protect islets…
2016 American Transplant Congress
Matrix Metalloproteinase-9 in Human Orthotopic Liver Transplant Biopsies.
S. Duarte, N. Datta, J. Baber, R. Busuttil, A. Zarrinpar, A. Coito.
The Dumont-UCLA Transplant Center, Los Angeles.
Liver ischemia reperfusion injury (IRI) is an inflammatory event that contributes to graft dysfunction in orthotopic liver transplantation (OLT). Matrix Metalloproteinases (MMPs) are responsible for…