Articles tagged "Inflammation"

2017 American Transplant Congress
The Role of Toll-Like Receptor 4 in Islet Transplantation and a Novel Method of Protection Using Chemical Surface Modification.
C. Chang,¹ G. Yoshimatsu,² B. Akinbobuyi,⁴ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco, TX; ²Baylor Scott and White Research Institute, Dallas, TX; ³Baylor Simmons Transplant Institute, Dallas, TX; ⁴Department of Chemistry and Biochemistry, Baylor University, Waco, TX
Toll-like Receptor 4 (TLR4) is the canonical receptor for lipopolysaccharide (LPS), however recent evidence reveals that TLR4 also plays an important role in ischemia-reperfusion injury…
2017 American Transplant Congress
Effect of Bone Marrow Derived Mesenchymal Stem Cells on Renal Ischemia-Reperfusion Injury in Rabbit.
J. Jang, H. Ri, I. Hong.
Agriculture & Life Science, Pyongyang University of Science & Technology, Pyongyang, Democratic Peoples Republic of Korea
Background: We succeeded to set up a rabbit model of Ischemia-Reperfusion (I/R) injury to test future candidate substance or plant extract that may have anti-oxidant…
2017 American Transplant Congress
Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.
Y. Ariyoshi, M. Sekijima, H. Sahara, T. Murokawa, A. Shimizu, K. Yamada.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…
2017 American Transplant Congress
Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation.
J. Kwun,¹ J. Lee,¹ J. Jackman,² M. Manook,¹ E. Elster,³ A. Kirk,¹ B. Sullenger.¹
¹Surgery, Duke University, Durham, NC; ²Biomedical Engineering, Duke University, Durham, NC; ³Surgery, Uniformed Services University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD
[Introduction] Trauma patients produce a host of danger signals and high levels of damage-associated molecular patterns (DAMPs) after cellular injury and tissue damage. Organs from…
2017 American Transplant Congress
Cibinetide (ARA 290), the Innate Repair Receptor Ligand, Improves Engraftment in Pancreatic Islet Transplantation by Protecting Islets and Reducing Inflammatory Reactions.
M. Watanabe,¹ M. Han Yao,¹ H. Zemack,¹ B.-G. Ericzon,¹ A. Cerami,² M. Brines,² T. Lundgren,¹ M. Kumagai-Braesch.¹
¹Department of Transplantation Surgery, CLINTEC, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; ²Araim Pharmaceuticals, Tarrytown, NY
Purpose. Cibinetide, an innate repair receptor ligand, exerts anti-inflammatory, anti-apoptotic, and cytoprotective effects. We have shown that cibinetide protected mouse pancreatic islets from cytokine-induced damage…
2017 American Transplant Congress
Mechanisms of Fibrosis in the Allograft Kidney: RNA-seq Based Analysis Using Formalin Fixed Biopsies.
G. Zeng,² L. Pan,¹ Z. Lyu,¹ Y. Huang,² P. Randhawa.²
¹Department of Nephrology, Guangxi Medical University, Nanning, Guangxi, China; ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Development of allograft fibrosis determines long term graft survival but our understanding of this important complication is incomplete. To gain further insight into this problem…
2017 American Transplant Congress
Autotransplantation of the Left Lung for the Treatment of Recurrent Life Threatening Pulmonary Hemorrhage Related to Pulmonary Vascular Malformation: A Unique Chance to Study Ischemia/Reperfusion Injury.
C. Falk,¹ I. Tudorache,² C. Müller,³ W. Sommer,² K. Daemen,¹ J. Keil,¹ G. Hansen,³ A. Haverich,² G. Warnecke,² N. Schwerk.³
¹Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany; ²Department of Cardiothoracic Transplant and Vascular Surgery, MHH, Hannover, Germany; ³Department of Pediatric Pneumology, MHH, Hannover, Deutschland, Germany
Background: Ischemia reperfusion injury (IRI) remains a major clinical problem in lung transplantation. Here, we report the investigation of IRI in a 17-year-old patient who…
2017 American Transplant Congress
Circulating Inflammatory Factors in Deceased Organ Donors Result in Innate Immune Activation.
T. Brennan, L. Lin, J. Pollara.
Surgery, Duke University, Durham, NC
Background: Superior outcomes of living-donor compared to deceased-donor transplants may be related to increased graft immunogenicity at the time of transplant. Donor brain death results…
2017 American Transplant Congress
Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.
G. Yoshimatsu,¹ M. Kanak,² C. Chang,¹ C. Darden,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwellth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…
2017 American Transplant Congress
IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.
G. Schiechl-Brachner,¹ M. Rodriguez Gomez,¹ K. Renner,¹ S. Buchtler,¹ K. Schmidbauer,¹ D. Halbritter,¹ S. Neumayer,¹ Y. Talke,¹ H. Bruehl,² M. Mack.¹
¹Department of Internal Medicine II, University Hospital / Medical Center, Regensburg, Germany; ²Department of Internal Medicine I, University Hospital / Medical Center, Regensburg, Germany
Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…