2017 American Transplant Congress
Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.
Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…2017 American Transplant Congress
Protective Effect of Crepidiastrum denticulatum Extract Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice.
Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to have bioactive compounds with detoxification and antioxidant properties. Ischemia-reperfusion…2017 American Transplant Congress
IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.
Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…2017 American Transplant Congress
Inflammatory Cytokines Are Associated with Angiotensin II Type 1 Receptor Antibodies and Vascular Inflammation in Pediatric Renal Transplantation.
1University of California, Los Angeles, CA; 2Duke University, Durham, NC
Background: We recently found that angiotensin II type 1 receptor antibody (AT1R-Ab) was associated with decreased renal function in pediatric renal transplant recipients independent of…2017 American Transplant Congress
Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).
Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…2017 American Transplant Congress
Ischemia Reperfusion Injury (IRI) Causes Local Release of Free Heme Which Aggravates Inflammation and Contributes to Delayed Graft Function.
Ischemia reperfusion injury (IRI) is relevant in solid organ transplantation and contributes to delayed graft function (DGF). In this study, release of free heme after…2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…2017 American Transplant Congress
Infusion of Polyclonal Tregs Modulates Subclinical Kidney Transplant Inflammation: Final Report of TASK Pilot Trial.
Purpose:Treg therapy can reverse established inflammation in animal models. We conducted a pilot safety & feasibility trial of Treg therapy for subclinical kidney transplant inflammation.Methods:Peripheral…2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
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