Articles tagged "Inflammation"

2017 American Transplant Congress
Prolonged Liver Ischemia Triggers Necrotic Depletion of TIM4+ Kupffer Cells to Facilitate Tissue Inflammatory Immune Activation in Liver Ischemia-Reperfusion Injury.
H. Wang,¹ S. Yue,¹ M. Ni,¹ R. Busittil,¹ J. Kupiec-Weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA; ²Liver Surgery, The First affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu Province, China
Although mechanisms of immune activation against liver ischemia-reperfusion injury (IRI) have been studied extensively, questions regarding liver resident Kupffer cells vs. infiltrating macrophages (iM[Oslash]s) remain…
2017 American Transplant Congress
Proteomic Profiles of Deceased Donor Kidney Biopsies Obtained Prior to Transplantation Correlate with Allograft Function at One Year.
M. Kaisar,^1,2 L. van Dullemen,¹ Z. Akhtar,¹ H. Huang,¹ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Introduction:Cerebral injury during Donation after Brain Death (DBD) will induce a systemic inflammatory response affecting immediate kidney function and survival posttransplantation. Assessment of donor organ…
2017 American Transplant Congress
Role of Protease Activated Receptor 1 and Sphingosine-1-Phospate Receptor 1 in Mice Hepatic Ischemia-Reperfusion Injury for Targeting Cell Signal Pathways of Activated Protein C.
T. Ito, N. Kuriyama, H. Kato, Y. Iizawa, A. Tanemura, Y. Murata, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan
Introduction: Hepatic ischemia-reperfusion injury (IRI) is a serious comlication during liver surgery. As for therapeutic strategies on hepatic IRI, we previously demonstrated that activated protein…
2017 American Transplant Congress
Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.
C. Laird,¹ B. French,¹ L. Burdorf,¹ X. Cheng,¹ W. Fogler,² J. Magnani,² C. Phelps,³ D. Ayares,³ A. Azimzadeh,¹ R. Pierson.¹
¹University of Maryland SOM, Baltimore; ²GlycoMimetics, Inc, Rockville; ³Revivicor, Inc, Blacksburg
Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…
2017 American Transplant Congress
Inhibition of Liver Natural Killer Cells Activation Through Co-Transplantation of Pre-Activated Mesenchymal Stem Cells Contributes to Improvement of Islet Graft Survival.
N. Ishida, K. Ishiyama, Y. Saeki, Y. Tanaka, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
Introduction: We have previously reported that enhancement of TNF-related apoptosis-inducing ligand (TRAIL)-mediated liver NK-cell activity after intraportal islet transplantation (IT) inhibits engraftment of islets. Recently,…
2017 American Transplant Congress
How to Promote Regeneration After Ischemic Reperfusion Injury: Dual Role of CD 137 Agonistic Antibody.
J. Lee,^1,3 H. Kim,³ H. Chung,¹ K. Park,¹ B. Kwon,^3,4 H. Cho.^2,3
¹Internal Medicine, Ulsan University Hospital and College of Medicine, University of Ulsan, Ulsan, Korea; ²Surgery, Ulsan University Hospital and College of Medicine, University, Ulsan, Korea; ³Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea; ⁴School of Biological Science, University of Ulsan, Ulsan, Korea
Acute sterile inflammation can be induced by tissue damage caused by ischemia-reperfusion. In transplantation ischemia reperfusion injury (IRI) is unavoidable procedure. IRI causes delayed graft…
2017 American Transplant Congress
Patterns of Monocyte Differentiation and Activation in a Non-Human Primate Model of Brain Death.
P. Chlebeck, J. Danobeitia, L. Zitur, T. Zens, X. Xu, S. Odorico, A. D'Alessandro, L. Fernandez.
Surgery - Division of Transplantation, University of Wisconsin-Madison, Madison, WI
Brain-death (BD) induces a systemic inflammatory response known to impair tissue perfusion and promote graft immunogenicity. Monocytes play a significant role in the regulation of…
2017 American Transplant Congress
Myeloid HO-1 Orchestrates Liver Graft Function via SIRT1/p53 Signaling: From Mouse-to-Human.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ N. Datta,¹ A. Zarrinpar,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Department of Medicine, UCLA, Los Angeles, CA; ³Department of Pathology, UCLA, Los Angeles, CA
Background/Aim: Although the efficacy of heme oxygenase-1 (HO-1) to combat liver ischemia-reperfusion injury (IRI) in animal models is well-established, cell-specific HO-1 function and mechanisms of…
2017 American Transplant Congress
Nafamostat Mesilate Ameliorates Ischemia-Reperfusion Renal Injury via Anti-Apoptotic Mechanism.
D. Choi,¹ J. Jeong,² H. Bae,¹ Y. Ham,¹ K. Lee,¹ K. Na.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: It has been reported that nafamostat mesilate inhibits inflammatory injury via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is…
2017 American Transplant Congress
CCR5-Mediated Recruitment of NK Cells to the Kidney Is Critical for Resistance to Candida albicans Infections.
J. Lee,^1,4 V. Tran,³ H. Kim,¹ B. Kwon,^1,3 K. Park,^1,4 H. Cho.^1,2
¹Biomedical Research Center, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, Republic of Korea; ²Department of Surgery, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, South Korea, Republic of Korea; ³School of Biological Sciences, University of Ulsan, Ulsan, South Korea, Republic of Korea; ⁴Department of Internal Medicine, Ulsan University Hospital and School of Medicine, University of Ulsan, Ulsan, South Korea, Republic of Korea
We previously showed that CCR5 mediates recruitment of NK cells to the kidney after renal ischemia and reperfusion, which in turn induce the production of…