Articles tagged "Inflammation"

2017 American Transplant Congress
Identification of NKG2D as Senescence Marker in Zero-Hour Kidney Biopsies Is Indicative for Clinical Outcome.
T. Resch,¹ J. Günther,¹ H. Hackl,² A. Sattler,³ S. Ebner,¹ P. Ritschl,³ M. Biebl,³ R. Öllinger,³ S. Schneeberger,¹ G. Brandacher,⁴ H. Schwelberger,¹ B. Zelger,⁵ D. Stauch,³ A. Pascher,³ J. Pratschke,³ K. Kotsch.³
¹Center of Operative Medicine, Department for Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; ²Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; ³Department for General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany; ⁴Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, John Hopkins University School of Medicine, Baltimore; ⁵Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
The definition of biological donor organ age rather than chronological age seems an obvious factor for the establishment of valid pre-transplant risk assessment. We therefore…
2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
2017 American Transplant Congress
Rapamycin Maintenance Therapy in Pediatric Liver Transplant Recipients Associated with Trend Toward Decreasing Th2 Cytokine Levels Compared to Tacrolimus Therapy.
R. Fischer,¹ A. Seng,² L. Gardner,² L. Steele,² L. Harvey,¹ H. Wasserkrug,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel,¹ T. Yankee.²
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS
Background: Maintenance immunosuppression after liver transplantation with tacrolimus (TAC) may have progressive fibrosis on serial allograft biopsies. mTOR inhibitors such as rapamycin (RAPA) may abrogate…
2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
J. Lee,^1,2 X. Zhang,² A. Haig,³ D. Lian,² P. Anderson,² R. Navaratnam,² L. Gunaratnam.^1,2
¹Department of Microbiology and Immunology, Western University, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Department of Pathology, Western University, London, ON, Canada
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…
2017 American Transplant Congress
Clinically Relevant Immunosuppression Promotes MCMV Reactivation and Dissemination Following Transplantation of Latently Infected Kidneys.
Z. Zhang,¹ S. Yan,¹ L. Zhao,¹ S. Kurian,² M. Hummel,¹ D. Salomon,² M. Abecassis.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago; ²Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla
Reactivation of latent Cytomegalovirus (CMV) is an important problem facing clinical transplantation. We have previously described a model for murine CMV (MCMV) reactivation following kidney…
2017 American Transplant Congress
Myeloid HO-1 Regulates M2 Macrophage Activation in Liver Ischemia-Reperfusion Injury (IRI).
K. Nakamura,¹ M. Zhang,² S. Kageyama,¹ B. Ke,¹ R. Sosa,³ E. Reed,³ A. Zarrinpar,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Department of Medicine, UCLA, Los Angeles, CA; ³Department of Pathology, UCLA, Los Angeles, CA
Background/Aim: Although anti-inflammatory macrophage differentiation (M2) from pro-inflammatory (M1) phenotype is critical for heme oxygenase-1 (HO-1) cytoprotection, the role of cell type-specific HO-1 induction remains…
2017 American Transplant Congress
Course of Inflammatory Bowel Disease Activity in Primary Sclerosing Cholangitis Patients Undergoing Liver Transplantation.
R. Parekh,¹ M. Segovia,² N. Kaur.¹
¹Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI; ²Gastroenterology and Hepatology, Duke University Medical Center, Durham, NC
Aim: Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to review disease activity of IBD in patients with PSC undergoing…
2017 American Transplant Congress
Extra-Renal Cardiac Injury Is Associated with Upregulation of NOD2 and Nlrp3 in the Heart After Renal IRI.
A. Scheinok, S. Kasimsetty, E. Soo, C. Nelson, A. Shigeoka, D. McKay.
Medicine, Division of Nephrology and Hypertension, University of California San Diego, La Jolla, CA
Background: Recent studies show renal ischemia reperfusion injury (IRI) is associated with systemic release of danger associated molecular patterns (DAMPs). DMAPs induce significant extra-renal organ…
2017 American Transplant Congress
Mycophenolic Acid Needs Ca²⁺ to Exert Its Anti-inflammatory Action via Shedding of Toll-Like Receptor4 and Tumor Necrosis Factor Receptor 1.
J. Kim,¹ W. Yang,¹ C. Baek,¹ N. Han,² S.-K. Park.¹
¹Division of Nephrology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; ²Asan Institute for Life Science, Seoul, Republic of Korea
Background Mycophenolic acid (MPA) has been used for many years to prevent transplantation rejection. Recently, it has been investigated for its anti-inflammatory effects. MPA can…
2017 American Transplant Congress
TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.
T. Fujii, S. Duarte, R. Busuttil, A. Coito.
Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation. Tissue inhibitor of metalloproteinases-3 (TIMP-3), an extracellular matrix-associated protein, has been linked…