Articles tagged "Inflammation"

2018 American Transplant Congress
Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation
R. Zhang,¹ H. Fang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…
2018 American Transplant Congress
Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury
N. Valenzuela.
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…
2018 American Transplant Congress
Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation
C. Moore,¹ M. Thijssen,^1,2 X. Wang,³ P. Mandrekar,³ E. Xiaofei,³ R. Abdi,⁴ R. Porte,² A. Bozorgzadeh,¹ H. Leuvenink,² T. Kowalik,³ P. Martins.¹
¹Dept of Surgery, University of Massachusetts, Worcester, MA; ²Dept of Surgery, Groningen University, Gronigen, Netherlands; ³Dept of Medicine, Univ. of Massachusetts, Worcester, MA; ⁴Transplant Research Institute, Harvard University, Boston, MA.
Background: RNA interference (RNAi) is a process through which RNA induces the activation of endogenous cellular pathways of RNA degradation, resulting in selective and potent…
2018 American Transplant Congress
Pro-Inflammatory B Cells Predict Progressive Minimal Early Renal Allograft Inflammation Which is Associated with Poor Graft Outcomes
A. Sharma, A. Cherukuri, D. Chittka, R. Mehta, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
The clinical significance of minimal tubulointerstitial inflammation (MTI:'t'+'i'scores 0.5-1.5) and Banff Borderline changes (BBC:'t'+'i'scores 2-3) in early renal allograft biopsies is unclear. The rate and…
2018 American Transplant Congress
Hyperglycemia-Triggered ATF6-CHOP Pathway Exacerbates Liver Ischemia/Reperfusion Injury: Immunomodulation by Regulating β-Catenin Signaling
J. Rao,^1,2 C. Yang,¹ Y. Hu,¹ S. Yang,¹ Y. Xia,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.^1,2
¹Department of Liver Surgery/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles.
Background & Aims: Hyperglycemia is a risk factor for hepatic ischemia/reperfusion injury (IRI) during liver transplantation or hepatectomy; however, the underlying mechanism remains unclear. Our…
2017 American Transplant Congress
Preceeding the Rejection: Clinical Results of a Saliva Test After Renal Transplantation.
D. Abendroth,¹ M. Marzinzig,¹ M. Stangl.²
¹Dept. of Surgery, University of Ulm, Ulm, Germany; ²Dept. of Visceral and Transplant Surgery, Ludwigs-Maximilians-Universität, Munich, Germany
Introduction There remains a need for biomarker in transplantation for monitoring and early identification of rejection episodes (R). We developed a colorimetric assay to detect…
2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
2017 American Transplant Congress
Quantity and Functions of CD4^–CD8^– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.
M. Sadasivam, S. Noel, S. Lee, A. Hamad, H. Rabb.
Johns Hopkins University, Baltimore, MD
Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…
2017 American Transplant Congress
Low Level Light Laser Treatment Reduces Macrophage Retention and ROS Levels Following Tissue Injury.
A. Paredes,¹ D. Benavidez,¹ R. Patil,¹ B. Khalil,¹ M. Mitchell,¹ J. Cheng,¹ S. Mangos,² A. Bartholomew.¹
¹University of Illinois, Chicago; ²Rush University, Chicago
Following ischemia reperfusion injury, inflamed macrophages switch from oxidative phosphorylation to glycolysis; in contrast, macrophages associated with tissue repair rely on oxidative phosphorylation. The triggers…
2017 American Transplant Congress
Normothermic Donor Lung Preservation with Portable EVLP Significantly Reduces Ischemia/Reperfusion Injury in Lung Recipients by Promoting Cytokine Antagonists.
C. Falk,¹ B. Wiegmann,² C. Neudörfl,¹ C. Kühn,² I. Tudorache,² M. Wvsar,² A. Haverich,² G. Warnecke.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Cardiothoracic Transplant and Vascular Surgery, MHH, Hannover, Germany
ObjectivesThe INSPIRE trial revealed significant reduction of PGD grade 3 using the Organ Care System (OCS) compared to the standard of care (SOC) for lung…