Articles tagged "Immunogenicity"

2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
B. Kern¹, J. Mengwasser¹, A. Reutzel-Selke¹, M. I. Ashraf¹, D. Polenz¹, K. Fuehrer¹, S. Lippert¹, P. Tang¹, F. Martin¹, C. Witzel¹, I. M. Sauer¹, J. Pratschke¹, S. G. Tullius²
¹Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
2021 American Transplant Congress
Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation
K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan
*Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
2021 American Transplant Congress
Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring
K. R. Sherwood¹, P. Wong¹, F. Fenninger¹, V. Wu¹, J. Beckrud², D. P. Cina³, L. Allan², J. Lan², P. A. Keown²
¹University of British Columbia, Vancouver, BC, Canada, ²Vancouver General Hospital, Vancouver, BC, Canada, ³Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada
*Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
2021 American Transplant Congress
Clearance of Viral RNA and DNA and Antibody Response Following Administration of Live Attenuated Measles and Varicella Vaccines in Children with Chronic Liver Disease
S. Kemme¹, A. Weinberg², A. G. Feldman¹
¹Children's Hospital Colorado, Denver, CO, ²University of Colorado Denver, Denver, CO
*Purpose: Guidelines recommend waiting four weeks between live vaccine administration and transplantation; however, there is little data to support this waiting period and it often…
2020 American Transplant Congress
Low Physiochemical Immunogenicity Scores Improve Long-Term Survival of Deceased Donor Kidney Transplants
D. Bekbolsynov¹, B. Mierzejewska¹, J. Borucka², S. A. Khuder¹, M. Rees¹, R. Green³, S. Stanislaw¹
¹University of Toledo, Toledo, OH, ²Parexel Corp., Warsaw, Poland, ³Bowling Green State University, Bowling Green, OH
*Purpose: A severe shortage of deceased donor kidneys limits access to kidney transplantation. Limited longterm graft function exacerbates this shortage as 12% of the waiting…
2020 American Transplant Congress
Contrary to Expectation, the Use of Immune Checkpoint Inhibitors is Not Consistently Associated with Early Onset Allograft Rejection in Solid Organ Transplant Recipients
I. Owoyemi¹, C. M. Costello², C. Thongprayoon¹, S. Markovic³, H. Joerg⁴, C. C. Otley⁵, T. Taner⁶, A. R. Mangold², N. Leung¹, S. Herrmann¹, A. Kukla¹
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²Department of Dermatology, Mayo Clinic, Scottsdale, AZ, ³Division of Medical Oncology, Mayo Clinic, Rochester, MN, ⁴Department of Cardiology, Mayo Clinic, Rochester, MN, ⁵Department of Dermatology, Mayo Clinic, Rochester, MN, ⁶Departments of Surgery & Immunology, Mayo Clinic, Rochester, MN
*Purpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but are generally avoided in solid organ transplant recipients (SOTRs) due to concern for allograft rejection…
2020 American Transplant Congress
Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation
H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. Fishbein, A. Kroemer
Transplant Institute, MedStar Georgetown University, Washington, DC
*Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…
2020 American Transplant Congress
The Reperfusion Response in Plasma of Combined Heart/ Lung Transplanted Patients is Guided by Heart-Associated Cytokine Patterns on Contrast to the Ischemic Injury in Perfusion Solutions Following a Lung-Associated Pattern
C. Falk¹, J. Kühne², L. Radomsky², F. Wandrer², B. Wiegmann³, N. Ledwoch², J. Keil², K. Beushausen², F. Ius³, W. Sommer³, S. Rojas-Hernandez³, I. Tudorache³, A. Haverich³, G. Warnecke³
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ³Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation but rarely compared directly in a clinical setting. Therefore, we compared a cohort…
2020 American Transplant Congress
Use of Subunit Herpes Zoster Vaccine in VZV-Seronegative Transplant Recipients to Prevent Primary Varicella
A. G. L'Huillier¹, V. H. Ferreira², C. Hirzel³, M. Ierullo², T. Ku², N. Selzner², J. Schiff², J. Tikkanen², C. Miao⁴, D. S. Schmid⁴, A. Humar², D. Kumar²
¹HUG, Geneva, Switzerland, ²UHN, Toronto, ON, Canada, ³Inselspital, Bern, Switzerland, ⁴CDC, Atlanta, GA
*Purpose: Varicella-zoster virus (VZV) primary infection can be prevented by using the live varicella vaccine. However, this is contraindicated after organ transplant. We investigated the…
2020 American Transplant Congress
Immune-Mediated Injury and Eplet Mismatches – Profiling Population-Level Interactions
H. Mohammadhassanzadeh¹, W. Zhang², W. Klement³, H. Gebel⁴, P. Keown⁵, K. Oualkacha⁶, R. Sapir-Pichhadze¹
¹Medicine, McGill University, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, ⁴Emory University Hospital, Atlanta, GA, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Université du Québec À Montréal, Montreal, QC, Canada
*Purpose: HLA genes are in linkage disequilibrium with each other. Sequence defined HLA targets (eplets) are associated with alleles and may be shared within and…