Articles tagged "Immunogenicity"

2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
B. Kern¹, J. Mengwasser¹, A. Reutzel-Selke¹, M. I. Ashraf¹, D. Polenz¹, K. Fuehrer¹, S. Lippert¹, P. Tang¹, F. Martin¹, C. Witzel¹, I. M. Sauer¹, J. Pratschke¹, S. G. Tullius²
¹Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
2021 American Transplant Congress
Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation
K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan
*Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
2021 American Transplant Congress
Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring
K. R. Sherwood¹, P. Wong¹, F. Fenninger¹, V. Wu¹, J. Beckrud², D. P. Cina³, L. Allan², J. Lan², P. A. Keown²
¹University of British Columbia, Vancouver, BC, Canada, ²Vancouver General Hospital, Vancouver, BC, Canada, ³Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada
*Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
2021 American Transplant Congress
Clearance of Viral RNA and DNA and Antibody Response Following Administration of Live Attenuated Measles and Varicella Vaccines in Children with Chronic Liver Disease
S. Kemme¹, A. Weinberg², A. G. Feldman¹
¹Children's Hospital Colorado, Denver, CO, ²University of Colorado Denver, Denver, CO
*Purpose: Guidelines recommend waiting four weeks between live vaccine administration and transplantation; however, there is little data to support this waiting period and it often…
2020 American Transplant Congress
Ranking Eplet Mismatches as Predictors of Graft Failure
W. Zhang¹, H. Mohammadhassanzadeh¹, K. Oualkacha², H. Gebel³, W. Klement⁴, R. Sapir-Pichhadze¹
¹McGill University, Montreal, QC, Canada, ²UQAM, Montreal, QC, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Canadian Blood Services, Ottawa, ON, Canada
*Purpose: Donor:recipient matching at the level of sequence defined HLA targets (eplets) is being promoted as a biologically sound strategy to prevent graft failure. Because…
2020 American Transplant Congress
Donor Kidney Perfusion Fluid Extracellular Vesicles as Markers of Graft Function
A. K. Rutman, S. Negi, N. Saberi, J. Tchervenkov, S. Paraskevas
Research Institute of the McGill University Health Institute, Montreal, QC, Canada
*Purpose: Kidney transplantation is a life-saving treatment for many patients with end-stage renal failure. Recently, machine perfusion of kidneys prior to transplantation has emerged as…
2020 American Transplant Congress
HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation
C. Wiebe¹, D. Pochinco², I. W. Gibson³, J. Ho¹, P. Birk⁴, A. Goldberg⁴, M. Karpinski⁵, J. Shaw⁵, R. N. David⁵, P. W. Nickerson¹
¹Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, ²Shared Health Services, Winnipeg, MB, Canada, ³Pathology, University of Manitoba, Winnipeg, MB, Canada, ⁴Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Medicine, University of Manitoba, Winnipeg, MB, Canada
*Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…
2020 American Transplant Congress
Impact of Eplet Mismatches on the Risk of Graft Loss: Not All Eplets are Created Equal
H. Mohammadhassanzadeh¹, W. Klement², H. Gebel³, B. Foster⁴, P. Keown⁵, K. Oualkacha⁶, R. Sapir-Pichhadze¹
¹Medicine, McGill University, Montreal, QC, Canada, ²Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Montreal Children's Hospital, Montreal, QC, Canada, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Université du Québec À Montréal, Montreal, QC, Canada
*Purpose: To mitigate risks related to HLA incompatibility, we assessed whether some unique sequence defined HLA targets (eplets) are associated with graft failure while others…
2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
C. Blanton¹, J. Reyes¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. vanAmersfoort², J. Torrealba³, Y. Yankol¹, A. D’Alessandro¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UTSouthwestern, Dallas, TX
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
2020 American Transplant Congress
Epitope Analysis of Complement-Binding De Novo Donor-Specific HLA Class II Antibody
K. Yamanaka, M. Hashimoto, T. Kinoshita, Y. Fujita, S. Matsumura, T. Imanaka, A. Taniguchi, T. Yoshida, H. Kishikawa
Department of Kidney Transplantation Center, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan
*Purpose: Patients with de novo donor specific antibody (dnDSA) after kidney transplantation have a poorer prognosis than patients without dnDSA. Meanwhile, patients with dnDSA do…