Articles tagged "Immunogenicity"

2021 American Transplant Congress
Precision Medicine in Renal Transplantation: Structural Biology of HLA Defines Allelic Binding of Cardinal Pathogenic Viruses in Transplantation
K. R. Sherwood¹, A. Nguyen², J. Tran¹, O. Gunther³, A. Nellore², R. Thompson², J. Lan¹, L. Allan¹, P. A. Keown¹
¹Vancouver General Hospital, Vancouver, BC, Canada, ²Biomedical Engineering, Oregon Health & Science University, Portland, OR, ³Gunther Analytics, Vancouver, BC, Canada
*Purpose: The incidence, clearance and clinical expression of viremia post-Tx are heterogeneous, complicating prediction, prognosis and therapy. We postulated that variation viral presentation related to…
2021 American Transplant Congress
HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity
J. Nevarez-Mejia¹, X. Wei¹, N. M. Valenzuela¹, M. Rossetti¹, H. Pickering¹, G. A. Fishbein¹, A. Mulder², E. F. Reed¹
¹Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands
*Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
B. Kern¹, J. Mengwasser¹, A. Reutzel-Selke¹, M. I. Ashraf¹, D. Polenz¹, K. Fuehrer¹, S. Lippert¹, P. Tang¹, F. Martin¹, C. Witzel¹, I. M. Sauer¹, J. Pratschke¹, S. G. Tullius²
¹Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, ²Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
2021 American Transplant Congress
Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation
K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan
*Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
2020 American Transplant Congress
Impact of Catch-Up Vaccinations on Anti-HLA Antibody Responses in Pediatric Kidney Transplant Candidates
H. Sweiss¹, J. Lyons², R. Hall¹, K. Hitchman³, D. Ranch⁴, E. Kincaide¹, B. Crowther⁵
¹University Health System, San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Loyola University Medical Center, Chicago, IL, ³University Health System, San Antonio, TX, ⁴The University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁵University of Colorado Health, Aurora, CO
*Purpose: Evaluate antibody (Ab) response after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC less than or equal…
2020 American Transplant Congress
Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation
J. A. Reyes¹, C. Blanton¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. van Amersfoort², J. Torrealba³, Y. Yankol¹, A. D'Allessandro¹, L. Fernandez¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UT Soutwestern, Dallas, TX
*Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…
2020 American Transplant Congress
Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs
K. Petitpas¹, B. Cerel¹, Z. Abady¹, L. Burdorf¹, D. L. Ayares², D. M. Magnani³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Revivicor, Blacksburg, VA, ³MassBiologics of UMMS, Boston, MA
*Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…
2020 American Transplant Congress
Molecular Features of HLA Mismatches as Predictors of De Novo DSA Development: A Single Center Experience
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Several molecular features (MoFs) of HLA mismatches (MMs) are currently used to predict the development of de novo donor-specific anti-HLA antibodies (dnDSA). The purpose…
2020 American Transplant Congress
HLA Mismatch Immunogenicity: Are We Predicating Mismatches That Induce De Novo DSA Development or That Do Not?
V. Jucaud¹, L. Rebellato², K. Briley², C. Haisch², S. Kendrick³, H. Jones³, K. Mclawhorn³, D. Leeser², M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC
*Purpose: Although the development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes, the prediction of…
2020 American Transplant Congress
The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study
A. Senev¹, M. Coemans¹, V. Van Sandt², E. Van Loon¹, J. Callemeyn¹, B. Sprangers¹, D. Kuypers¹, M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²HILA, Red Cross-Flanders, Mechelen, Belgium
*Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…