Articles tagged "Immunogenicity"

2022 American Transplant Congress
Sars-cov-2 Antibody and T Cell Response After Vaccination with or without Intensified Immunosuppression Among Pediatric Renal Transplant Recipients
H. Pizzo¹, B. Shin², P. R. Soni³, S. Nadipuram³, J. Garrison², R. Zhang², S. C. Jordan², D. Puliyanda¹
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ³Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Recent data has shown poor antibody response to SARS-CoV-2 vaccination among adult kidney transplant (tx) recipients, with seroconversion ranging between 22%-58% after two mRNA…
2022 American Transplant Congress
Induction of Tolerance After Intestinal Transplantation in a Porcine Model
S. Merl, R. Jones, B. Chen, M. Sykes, K. Yamada, J. Weiner
Columbia Center for Translational Immunology, Columbia University, New York, NY
*Purpose: We describe a case of tolerance from our study investigating multilineage chimerism under immunological conditions after intestinal transplantation using a porcine model with defined…
2022 American Transplant Congress
Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?
S. Jacob¹, M. L. Baack², A. Savinov³, P. J. Wettstein⁴
¹Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, ²Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, ³Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, ⁴Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN
*Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
2022 American Transplant Congress
First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy
J. Slatinska¹, B. Vanhove², M. Kolarova¹, F. Shneiker², J. Rousse², C. Galli³, J. Bach⁴, E. Cozzi⁵, J. Soulillou⁶, O. Duvaux², O. Viklicky¹
¹Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Xenothera, Nantes, France, ³Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, ⁴IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, ⁵Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, ⁶Nantes Universités, Nantes, France
*Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
2022 American Transplant Congress
MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation
H. Xu, L. Wang, V. A. Bendersky, Q. Gao, Q. Li, A. D. Kirk, H. Xu
Duke University School of Medicine, Durham, NC
*Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…
2022 American Transplant Congress
Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents
Y. Sambandam¹, J. He¹, N. Vanderhyde², L. Gallon¹, J. Leventhal¹, J. Mathew¹
¹Northwestern University, Chicago, IL, ²IsoPlexis, Branford, CT
*Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…
2022 American Transplant Congress
Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets
R. Matsumoto
Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan
*Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
2022 American Transplant Congress
3D Co-Culture System with Porcine Aortic Endothelial Cell Line and Human or Non-Human Primate Cells for Application in the Study of Xeno-Immune Reaction
S. K. Yadav¹, Y. Lee², S. Hurh³, S. Kim², J. Yang⁴, J. C. Jeong²
¹Medicine, Seoul National University, Seoul, Korea, Republic of, ²Internal Medicine (Nephrology), Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, ³Medicine, Korea University, Seoul, Korea, Republic of, ⁴Internal Medicine (Nephrology), Yonsei University, Seoul, Korea, Republic of
*Purpose: Neutrophil Extracellular Trap (NET) is a vigorous immune reaction of neutrophil. It plays role in xenotransplantation rejection. Functional assay of NET is important; however,…
2022 American Transplant Congress
Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept
J. Mitchell¹, J. Alejo¹, T. P. Chiang¹, J. N. Blankson¹, A. H. Karaba¹, B. Woldemeskel¹, C. Garliss¹, A. Chang¹, A. Abedon¹, R. K. Avery¹, A. Tobian¹, A. B. Massie¹, J. Garonzik-Wang², D. L. Segev¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin, Madison, WI
*Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…
2022 American Transplant Congress
Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV
M. Saksena¹, G. Carrara², B. Haydel², A. Azad¹, K. Srivastava¹, C. Gleason¹, K. Beach¹, L. Sominsky¹, A. Oostenink¹, G. Cai¹, J. Carreno Quiroz¹, G. Singh¹, S. Florman², C. Cordon-Cardo³, J. Aberg⁴, A. Wajnberg⁵, F. Krammer¹, V. Simon¹, M. Rana⁴
¹Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, ³Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…

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