ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2020 American Transplant Congress

    Role of B-Cell Subsets in Allograft Rejection in Intestinal Transplantation

    H. Dhani, N. Svetlicky, J. Kang, S. Moturi, A. Duttargi, K. Khan, C. Matsumoto, T. Fishbein, A. Kroemer

    Transplant Institute, MedStar Georgetown University, Washington, DC

    *Purpose: While B-cells contribute to allograft rejection by presenting antigens to T-cells and by producing donor-specific antibodies (DSAs) and various cytokines, their pathophysiology in transplant…
  • 2020 American Transplant Congress

    The Reperfusion Response in Plasma of Combined Heart/ Lung Transplanted Patients is Guided by Heart-Associated Cytokine Patterns on Contrast to the Ischemic Injury in Perfusion Solutions Following a Lung-Associated Pattern

    C. Falk1, J. Kühne2, L. Radomsky2, F. Wandrer2, B. Wiegmann3, N. Ledwoch2, J. Keil2, K. Beushausen2, F. Ius3, W. Sommer3, S. Rojas-Hernandez3, I. Tudorache3, A. Haverich3, G. Warnecke3

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, 3Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany

    *Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation but rarely compared directly in a clinical setting. Therefore, we compared a cohort…
  • 2020 American Transplant Congress

    Use of Subunit Herpes Zoster Vaccine in VZV-Seronegative Transplant Recipients to Prevent Primary Varicella

    A. G. L'Huillier1, V. H. Ferreira2, C. Hirzel3, M. Ierullo2, T. Ku2, N. Selzner2, J. Schiff2, J. Tikkanen2, C. Miao4, D. S. Schmid4, A. Humar2, D. Kumar2

    1HUG, Geneva, Switzerland, 2UHN, Toronto, ON, Canada, 3Inselspital, Bern, Switzerland, 4CDC, Atlanta, GA

    *Purpose: Varicella-zoster virus (VZV) primary infection can be prevented by using the live varicella vaccine. However, this is contraindicated after organ transplant. We investigated the…
  • 2020 American Transplant Congress

    Immune-Mediated Injury and Eplet Mismatches – Profiling Population-Level Interactions

    H. Mohammadhassanzadeh1, W. Zhang2, W. Klement3, H. Gebel4, P. Keown5, K. Oualkacha6, R. Sapir-Pichhadze1

    1Medicine, McGill University, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada, 3Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, 4Emory University Hospital, Atlanta, GA, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6Université du Québec À Montréal, Montreal, QC, Canada

    *Purpose: HLA genes are in linkage disequilibrium with each other. Sequence defined HLA targets (eplets) are associated with alleles and may be shared within and…
  • 2020 American Transplant Congress

    T Cell Activation by Allogeneic EVs and Allogeneic MHC Cross-Dressed Cells In Vitro and In Vivo

    A. Prunevieille1, B. Gonzalez-Nolasco1, G. Benichou1, N. Mooney2, A. Colleen3

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2INSERM, Paris, France, 3Boston College, Boston, MA

    *Purpose: The recognition of donor-MHC molecules by recipient T cells triggers the immune response leading to rejection of allografts. Our recent studies have documented the…
  • 2020 American Transplant Congress

    Effect of Simultaneous Presence of Anti-Blood Group A/B and -HLA Antibodies on Clinical Outcomes in Kidney Transplantation Across Positive Crossmatch: A Nationwide Cohort Study

    H. Kwon, Y. Ko, D. Han

    Department of General Surgery, Asan Medical Center, Seoul, Korea, Republic of

    *Purpose: ABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM positive…
  • 2020 American Transplant Congress

    Ranking Eplet Mismatches as Predictors of Graft Failure

    W. Zhang1, H. Mohammadhassanzadeh1, K. Oualkacha2, H. Gebel3, W. Klement4, R. Sapir-Pichhadze1

    1McGill University, Montreal, QC, Canada, 2UQAM, Montreal, QC, Canada, 3Emory University Hospital, Atlanta, GA, 4Canadian Blood Services, Ottawa, ON, Canada

    *Purpose: Donor:recipient matching at the level of sequence defined HLA targets (eplets) is being promoted as a biologically sound strategy to prevent graft failure. Because…
  • 2020 American Transplant Congress

    Donor Kidney Perfusion Fluid Extracellular Vesicles as Markers of Graft Function

    A. K. Rutman, S. Negi, N. Saberi, J. Tchervenkov, S. Paraskevas

    Research Institute of the McGill University Health Institute, Montreal, QC, Canada

    *Purpose: Kidney transplantation is a life-saving treatment for many patients with end-stage renal failure. Recently, machine perfusion of kidneys prior to transplantation has emerged as…
  • 2020 American Transplant Congress

    HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation

    C. Wiebe1, D. Pochinco2, I. W. Gibson3, J. Ho1, P. Birk4, A. Goldberg4, M. Karpinski5, J. Shaw5, R. N. David5, P. W. Nickerson1

    1Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, 2Shared Health Services, Winnipeg, MB, Canada, 3Pathology, University of Manitoba, Winnipeg, MB, Canada, 4Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, 5Medicine, University of Manitoba, Winnipeg, MB, Canada

    *Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…
  • 2020 American Transplant Congress

    Impact of Eplet Mismatches on the Risk of Graft Loss: Not All Eplets are Created Equal

    H. Mohammadhassanzadeh1, W. Klement2, H. Gebel3, B. Foster4, P. Keown5, K. Oualkacha6, R. Sapir-Pichhadze1

    1Medicine, McGill University, Montreal, QC, Canada, 2Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, 3Emory University Hospital, Atlanta, GA, 4Montreal Children's Hospital, Montreal, QC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada, 6Université du Québec À Montréal, Montreal, QC, Canada

    *Purpose: To mitigate risks related to HLA incompatibility, we assessed whether some unique sequence defined HLA targets (eplets) are associated with graft failure while others…
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