2018 American Transplant Congress
Impact of Immunogenicity on Kidney Allograft Survival in Patients Treated with Induction Therapy
Background. The induction therapy is currently used in the majority of kidney transplant recipients, regardless of their level of donor/recipient compatibility. We examined whether lower…2018 American Transplant Congress
Immunogenic HLA Mismatches and Evidence That Belatacept May Be the First Therapy Able to Prevent DQ De Novo DSA: An Analysis of the BENEFIT and BENEFIT-EXT Trial Cohorts
The use of belatacept over cyclosporine is associated with lower rates of DSA development in adult kidney transplantation. However, the effect of belatacept on the…2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…2018 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses Acute Allograft Rejection and Prolongs Graft Survival in Murine Heart Transplantation
Department of Urology, Sapporo Medical University, Sapporo, Japan.
Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor to recipients prolonged the allograft survival in murine skin and…2017 American Transplant Congress
In Vitro Optimisation of the Immunotherapeutic Effects of Umbilical Cord Derived MSC.
Mesenchymal stromal cells (MSC) possess immunomodulatory properties and are low immunogenic, which are both important for their development into an effective cellular immunotherapy after organ…2017 American Transplant Congress
Soluble Human Leukocyte Antigen-G Levels and Prolonged Allograft Survival: A Demographic Analysis.
Human leukocyte antigen-G (HLA-G) is a tolerogenic protein shown to contribute to allograft survival. Dimerized, soluble HLA-G (sHLA-Gd) has been shown to significantly prolong allograft…2017 American Transplant Congress
Circulating Inflammatory Factors in Deceased Organ Donors Result in Innate Immune Activation.
Surgery, Duke University, Durham, NC
Background: Superior outcomes of living-donor compared to deceased-donor transplants may be related to increased graft immunogenicity at the time of transplant. Donor brain death results…2017 American Transplant Congress
Rapamycin Directly Alters Human Endothelial Cell Alloimmunogenicity.
The mTOR inhibitor rapamycin (Rapa) is known to suppress T cell function. However, many of its in vivo effects, particularly its synergistic effects with costimulation…2017 American Transplant Congress
Extra-Renal Cardiac Injury Is Associated with Upregulation of NOD2 and Nlrp3 in the Heart After Renal IRI.
Medicine, Division of Nephrology and Hypertension, University of California San Diego, La Jolla, CA
Background: Recent studies show renal ischemia reperfusion injury (IRI) is associated with systemic release of danger associated molecular patterns (DAMPs). DMAPs induce significant extra-renal organ…2017 American Transplant Congress
Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix
Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…
American Transplant Congress abstracts