2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…2020 American Transplant Congress
Epitope Analysis of Complement-Binding De Novo Donor-Specific HLA Class II Antibody
*Purpose: Patients with de novo donor specific antibody (dnDSA) after kidney transplantation have a poorer prognosis than patients without dnDSA. Meanwhile, patients with dnDSA do…2020 American Transplant Congress
Impact of Catch-Up Vaccinations on Anti-HLA Antibody Responses in Pediatric Kidney Transplant Candidates
*Purpose: Evaluate antibody (Ab) response after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC less than or equal…2020 American Transplant Congress
Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation
*Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…2020 American Transplant Congress
Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs
*Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…2019 American Transplant Congress
Mismatched Epitope and De Novo DSA Development: An Analysis of the Benefit and Benefit-EXT Renal Transplant Cohorts
*Purpose: De novo donor-specific HLA antibodies (dnDSA) target epitopes rather than whole antigens, and their development is associated with the mismatched HLA antibody epitope load…2019 American Transplant Congress
Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity
*Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…2019 American Transplant Congress
Physiochemical Hla Properties Identify Low Immunogenic Donor/recipient Pairs Predicting Long-term Kidney Graft Survivals
1Gift of Life Michigan, Ann Arbor, MI, 2University of Toledo, Toledo, OH
*Purpose: Although it is well-recognized that HLA matching improves the long-term kidney graft survival, less than 10% of transplants are currently HLA matched. We measured…2019 American Transplant Congress
A Comparison of Cell-Mediated Immune Responses among Organ Transplant Recipients Receiving High-Dose vs Standard-Dose Influenza Vaccine
University Health Network, Toronto, ON, Canada
*Purpose: The High-dose (HD) influenza vaccine has been shown to induce better humoral immunity than the standard-dose (SD) vaccine in solid organ transplant (SOT) patients.…
American Transplant Congress abstracts