ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2020 American Transplant Congress

    Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates

    C. Blanton1, J. Reyes1, M. Eerhart1, P. Chlebeck1, M. Springer1, Y. Ponstein2, E. vanAmersfoort2, J. Torrealba3, Y. Yankol1, A. D’Alessandro1, L. Fernandez1

    1University of Wisconsin, Madison, WI, 2Pharming Technologies BV, Leiden, Netherlands, 3Pathology, UTSouthwestern, Dallas, TX

    *Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
  • 2020 American Transplant Congress

    Epitope Analysis of Complement-Binding De Novo Donor-Specific HLA Class II Antibody

    K. Yamanaka, M. Hashimoto, T. Kinoshita, Y. Fujita, S. Matsumura, T. Imanaka, A. Taniguchi, T. Yoshida, H. Kishikawa

    Department of Kidney Transplantation Center, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan

    *Purpose: Patients with de novo donor specific antibody (dnDSA) after kidney transplantation have a poorer prognosis than patients without dnDSA. Meanwhile, patients with dnDSA do…
  • 2020 American Transplant Congress

    Impact of Catch-Up Vaccinations on Anti-HLA Antibody Responses in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons2, R. Hall1, K. Hitchman3, D. Ranch4, E. Kincaide1, B. Crowther5

    1University Health System, San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Loyola University Medical Center, Chicago, IL, 3University Health System, San Antonio, TX, 4The University of Texas Health Science Center at San Antonio, San Antonio, TX, 5University of Colorado Health, Aurora, CO

    *Purpose: Evaluate antibody (Ab) response after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC less than or equal…
  • 2020 American Transplant Congress

    Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation

    J. A. Reyes1, C. Blanton1, M. Eerhart1, P. Chlebeck1, M. Springer1, Y. Ponstein2, E. van Amersfoort2, J. Torrealba3, Y. Yankol1, A. D'Allessandro1, L. Fernandez1

    1Surgery, University of Wisconsin, Madison, WI, 2Pharming Technologies BV, Leiden, Netherlands, 3Pathology, UT Soutwestern, Dallas, TX

    *Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…
  • 2020 American Transplant Congress

    Sialoadhesin Mediates the Adhesion of Human RBC to Porcine Macrophages from Genetically Engineered Pigs

    K. Petitpas1, B. Cerel1, Z. Abady1, L. Burdorf1, D. L. Ayares2, D. M. Magnani3, R. N. Pierson III1, A. M. Azimzadeh1

    1Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 2Revivicor, Blacksburg, VA, 3MassBiologics of UMMS, Boston, MA

    *Purpose: The sequestration of human RBC is prominent after liver and lung xenotransplantation. Rees et al previously implicated porcine sialoadhesin in adhesion of human RBC…
  • 2019 American Transplant Congress

    Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons1, D. Ranch2, K. Hitchman2, E. Kincaide1, B. Crowther1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
  • 2019 American Transplant Congress

    Mismatched Epitope and De Novo DSA Development: An Analysis of the Benefit and Benefit-EXT Renal Transplant Cohorts

    V. Jucaud1, V. Burnett1, H. Gebel2, R. Bray2, M. Polinsky3, M. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2Emory University, Atlanta, GA, 3Bristol-Myers Squibb, Princeton, NJ

    *Purpose: De novo donor-specific HLA antibodies (dnDSA) target epitopes rather than whole antigens, and their development is associated with the mismatched HLA antibody epitope load…
  • 2019 American Transplant Congress

    Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity

    H. C. Copley1, M. Elango1, V. Kosmoliaptsis2

    1Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital, Cambridge, United Kingdom, 2University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital & NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation at the University of Cambridge, Cambridge, UK., Cambridge, United Kingdom

    *Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…
  • 2019 American Transplant Congress

    Physiochemical Hla Properties Identify Low Immunogenic Donor/recipient Pairs Predicting Long-term Kidney Graft Survivals

    D. Bekbolsynov1, B. Mierzejewska2, C. Ho1, M. Rees2, S. Stepkowski2

    1Gift of Life Michigan, Ann Arbor, MI, 2University of Toledo, Toledo, OH

    *Purpose: Although it is well-recognized that HLA matching improves the long-term kidney graft survival, less than 10% of transplants are currently HLA matched. We measured…
  • 2019 American Transplant Congress

    A Comparison of Cell-Mediated Immune Responses among Organ Transplant Recipients Receiving High-Dose vs Standard-Dose Influenza Vaccine

    A. G. L'Huillier, V. H. Ferreira, Y. Natori, T. Ku, C. Hirzel, M. Ierullo, A. Humar, D. Kumar

    University Health Network, Toronto, ON, Canada

    *Purpose: The High-dose (HD) influenza vaccine has been shown to induce better humoral immunity than the standard-dose (SD) vaccine in solid organ transplant (SOT) patients.…
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