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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept

    J. Mitchell1, J. Alejo1, T. P. Chiang1, J. N. Blankson1, A. H. Karaba1, B. Woldemeskel1, C. Garliss1, A. Chang1, A. Abedon1, R. K. Avery1, A. Tobian1, A. B. Massie1, J. Garonzik-Wang2, D. L. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin, Madison, WI

    *Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…
  • 2022 American Transplant Congress

    Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV

    M. Saksena1, G. Carrara2, B. Haydel2, A. Azad1, K. Srivastava1, C. Gleason1, K. Beach1, L. Sominsky1, A. Oostenink1, G. Cai1, J. Carreno Quiroz1, G. Singh1, S. Florman2, C. Cordon-Cardo3, J. Aberg4, A. Wajnberg5, F. Krammer1, V. Simon1, M. Rana4

    1Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, 3Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…
  • 2022 American Transplant Congress

    An Additional Dose Of Viral Vector Covid-19 Vaccine And Mrna Covid-19 Vaccine In Kidney Transplant Recipients: A Randomized Controlled Trial

    J. Bruminhent1, C. Setthaudom2, P. Phornkittikorn3, P. Chaumdee3, S. Prasongtanakij4, S. Srisala4, K. Malathum1, S. Boongird5, A. Nongnuch5, M. Assanatham5, S. Kiertiburanakul1

    1Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 2Immunology Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 3Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 4Office of Research, Academic Affairs and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 5Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    *Purpose: An additional dose of the COVID-19 vaccine following a primary series is recommended for solid organ transplant recipients. However, a comparison of the immunogenicity…
  • 2022 American Transplant Congress

    Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration

    N. M. Ali1, S. Mehta1, V. Tatapudi1, A. Mattoo1, I. Soomro1, J. Benstein1, H. Neumann1, F. Zervou1, J. Miles2, R. Montgomery1

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, CA

    *Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
  • 2022 American Transplant Congress

    Differences in Strength and Longevity of SARS-CoV-2-Specific Adaptive Immunity Between Convalescent and Vaccinated SOT Patients and Immunocompetent Individuals

    L. Donadeu1, S. Gomez1, A. Fava'2, E. Crespo1, F. Moreso3, M. Lopez3, L. Lladó4, J. González4, I. Campos3, M. Muñoz3, J. Quintero3, J. Esperalba3, O. Bestard3

    1Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, 2Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, 3Vall d’Hebron University Hospital (HUVH), Barcelona, Spain, 4Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain

    *Purpose: Short-term adaptive immune memory has been reported among immunocompetent (IC) and convalescent Solid Organ Transplant (SOT) individuals following SARS-CoV-2 infection as well as after…
  • 2022 American Transplant Congress

    Immunogenicity and Safety of SARS-CoV-2 Vaccines and Breakthrough Infections Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis

    A. Villavicencio1, Y. Ebisu2, M. Raja3, A. P. Sanchez-Covarrubias1, S. Anjan3, J. M. Reynolds1, J. Simkins3, J. Camargo3, M. I. Morris3, L. Abbo4, G. Guerra5, Y. Natori6

    1Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, 2Kameda Medical Center, Chiba, Japan, 3University of Miami Miller School of Medicine, Miami, FL, 4University Of Miami Miller School of Medicine, Miami, FL, 5University of Miami Jackson Memorial Hospital, Miami, FL, 6University of Miami, Pinecrest, FL

    *Purpose: The SARS-CoV-2 pandemic has had a significant impact on the field of solid organ transplant(SOT). Immunization against SARS-CoV-2 is globally available since 2021. SOT…
  • 2021 American Transplant Congress

    Tissue Specific Antigen-presentation in VCA Transplantation

    B. Kern1, J. Mengwasser1, A. Reutzel-Selke1, M. I. Ashraf1, D. Polenz1, K. Fuehrer1, S. Lippert1, P. Tang1, F. Martin1, C. Witzel1, I. M. Sauer1, J. Pratschke1, S. G. Tullius2

    1Dept. of Surgery, Charité Campus CCM|CVK, Universitaetsmedizin Berlin, Germany, Berlin, Germany, 2Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…
  • 2021 American Transplant Congress

    Hla-dq Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation and Acute Cellular Rejection After Living Donor Liver Transplantation

    K. Ono, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, N. Tanimine, S. Akimoto, Y. Imaoka, K. Sato, H. Yamane, N. Tsukiyama, R. Ide, T. Mochizuki, H. Ohdan

    Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan

    *Purpose: Epitope mismatch (MM) effect on living donor liver transplantation (LDLT) has not been studied in detail. This study aimed to investigate the role of…
  • 2021 American Transplant Congress

    Precision Medicine in Renal Transplantation: T-cell Repertoire Sequencing to Define Donor-specific Clones for Post-transplant Monitoring

    K. R. Sherwood1, P. Wong1, F. Fenninger1, V. Wu1, J. Beckrud2, D. P. Cina3, L. Allan2, J. Lan2, P. A. Keown2

    1University of British Columbia, Vancouver, BC, Canada, 2Vancouver General Hospital, Vancouver, BC, Canada, 3Urologic Sciences, Vancouver General Hospital, Vancouver, BC, Canada

    *Purpose: Measuring donor-specific clonal responses offers a precise, sensitive and specific biomarker of immune recognition and activation. Combining deep immunophenotyping (DI) and T-cell receptor (TCR)…
  • 2021 American Transplant Congress

    Clearance of Viral RNA and DNA and Antibody Response Following Administration of Live Attenuated Measles and Varicella Vaccines in Children with Chronic Liver Disease

    S. Kemme1, A. Weinberg2, A. G. Feldman1

    1Children's Hospital Colorado, Denver, CO, 2University of Colorado Denver, Denver, CO

    *Purpose: Guidelines recommend waiting four weeks between live vaccine administration and transplantation; however, there is little data to support this waiting period and it often…
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