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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach

    H. Tejeda Mora1, J. Willemse2, Y. den Hartog1, I. Schurink2, M. M. Verstegen2, J. de Jonge2, R. C. Minnee2, M. W. van den Hoogen2, C. C. Baan1, L. J. van der Laan2, M. J. Hoogduijn1

    1Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 2Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
  • 2022 American Transplant Congress

    Immunogenicity of a Quadrivalent Human Papillomavirus Vaccine in Pediatric Kidney and Liver Transplant Recipients

    T. Kitano1, K. Schwartz2, M. Abdulnoor1, H. Garfield3, N. K. Booran1, Y. Avitzur1, C. Teoh1, D. Hebert4, U. Allen3

    1Hospital for Sick Children, Toronto, ON, Canada, 2Public Health Ontario, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Solid-organ transplant recipients are at increased risk of developing human papillomavirus (HPV)-related diseases. The immunogenicity of HPV vaccine for solid-organ transplant population needs further…
  • 2022 American Transplant Congress

    Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients

    Y. Yoo1, J. Husson2, T. Iraguha3, S. Niederhaus4, X. Wen5, A. Crane5, A. Carrier5, J. Avruch5, A. Ahuja6, M. Mathew7, S. Dahiya8, A. P. Rapoport8, D. Atanackovic8, K. K. Saharia2

    1Inst of Human Virology, Baltimore, MD, 2Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, 3Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, 4Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, 5Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, 6Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, 7Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, 8Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD

    *Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
  • 2022 American Transplant Congress

    Identification of Soluble and Cellular Biomarkers in Blood of End-Stage Patients Before Pediatric Liver Transplantation (pLTx)

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro5, J. Pawlowska10, R. Mikolajczyk11, U. Baumann12, C. Falk13

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hôpital Necker-Enfants Malades, Paris, France, 7Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Children's Hospital, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 11German Center for Infection Research, TTU-IICH Hannover; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, 12Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK; European Paediatric Liver Transplantation Network, Hannover, Germany, 13Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed to identify soluble and cellular biomarkers in blood of various end-stage diseases before pLTx.*Methods: Using flow…
  • 2022 American Transplant Congress

    QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF

    S. Ghosh1, H. Tedesco2, R. Sarwal1, N. Titzler1, W. Yazar1, M. Nakamura2, J. Pestana2, M. Sarwal1

    1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil

    *Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…
  • 2022 American Transplant Congress

    Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro10, J. Pawlowska11, P. Czubkowski11, R. Mikolajczyk12, U. Baumann13, C. Falk14

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Hannover; Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hannover; Hôpital Necker-Enfants Malades, Paris, France, 7Hannover; Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Children's Hospital, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Ospedali Riuniti di Bergamo, Bergamo, Italy, 11Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 12German Center for Infection Research, TTU-IICH Hannover; MHH; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, 13Birmingham Children’s Hospital, UK; Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, 14Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…
  • 2022 American Transplant Congress

    Sars-cov-2 Antibody and T Cell Response After Vaccination with or without Intensified Immunosuppression Among Pediatric Renal Transplant Recipients

    H. Pizzo1, B. Shin2, P. R. Soni3, S. Nadipuram3, J. Garrison2, R. Zhang2, S. C. Jordan2, D. Puliyanda1

    1Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 3Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Recent data has shown poor antibody response to SARS-CoV-2 vaccination among adult kidney transplant (tx) recipients, with seroconversion ranging between 22%-58% after two mRNA…
  • 2022 American Transplant Congress

    Induction of Tolerance After Intestinal Transplantation in a Porcine Model

    S. Merl, R. Jones, B. Chen, M. Sykes, K. Yamada, J. Weiner

    Columbia Center for Translational Immunology, Columbia University, New York, NY

    *Purpose: We describe a case of tolerance from our study investigating multilineage chimerism under immunological conditions after intestinal transplantation using a porcine model with defined…
  • 2022 American Transplant Congress

    Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?

    S. Jacob1, M. L. Baack2, A. Savinov3, P. J. Wettstein4

    1Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, 2Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, 3Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, 4Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN

    *Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
  • 2022 American Transplant Congress

    First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy

    J. Slatinska1, B. Vanhove2, M. Kolarova1, F. Shneiker2, J. Rousse2, C. Galli3, J. Bach4, E. Cozzi5, J. Soulillou6, O. Duvaux2, O. Viklicky1

    1Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Xenothera, Nantes, France, 3Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, 4IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, 5Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, 6Nantes Universités, Nantes, France

    *Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
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