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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    An Additional Dose Of Viral Vector Covid-19 Vaccine And Mrna Covid-19 Vaccine In Kidney Transplant Recipients: A Randomized Controlled Trial

    J. Bruminhent1, C. Setthaudom2, P. Phornkittikorn3, P. Chaumdee3, S. Prasongtanakij4, S. Srisala4, K. Malathum1, S. Boongird5, A. Nongnuch5, M. Assanatham5, S. Kiertiburanakul1

    1Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 2Immunology Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 3Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 4Office of Research, Academic Affairs and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 5Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    *Purpose: An additional dose of the COVID-19 vaccine following a primary series is recommended for solid organ transplant recipients. However, a comparison of the immunogenicity…
  • 2022 American Transplant Congress

    Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration

    N. M. Ali1, S. Mehta1, V. Tatapudi1, A. Mattoo1, I. Soomro1, J. Benstein1, H. Neumann1, F. Zervou1, J. Miles2, R. Montgomery1

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, CA

    *Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
  • 2022 American Transplant Congress

    Differences in Strength and Longevity of SARS-CoV-2-Specific Adaptive Immunity Between Convalescent and Vaccinated SOT Patients and Immunocompetent Individuals

    L. Donadeu1, S. Gomez1, A. Fava'2, E. Crespo1, F. Moreso3, M. Lopez3, L. Lladó4, J. González4, I. Campos3, M. Muñoz3, J. Quintero3, J. Esperalba3, O. Bestard3

    1Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, 2Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, 3Vall d’Hebron University Hospital (HUVH), Barcelona, Spain, 4Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain

    *Purpose: Short-term adaptive immune memory has been reported among immunocompetent (IC) and convalescent Solid Organ Transplant (SOT) individuals following SARS-CoV-2 infection as well as after…
  • 2022 American Transplant Congress

    Immunogenicity and Safety of SARS-CoV-2 Vaccines and Breakthrough Infections Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis

    A. Villavicencio1, Y. Ebisu2, M. Raja3, A. P. Sanchez-Covarrubias1, S. Anjan3, J. M. Reynolds1, J. Simkins3, J. Camargo3, M. I. Morris3, L. Abbo4, G. Guerra5, Y. Natori6

    1Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, 2Kameda Medical Center, Chiba, Japan, 3University of Miami Miller School of Medicine, Miami, FL, 4University Of Miami Miller School of Medicine, Miami, FL, 5University of Miami Jackson Memorial Hospital, Miami, FL, 6University of Miami, Pinecrest, FL

    *Purpose: The SARS-CoV-2 pandemic has had a significant impact on the field of solid organ transplant(SOT). Immunization against SARS-CoV-2 is globally available since 2021. SOT…
  • 2022 American Transplant Congress

    Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation

    S. Vasu1, C. Darden2, J. Mattke2, Y. Liu3, M. C. Lawrence3, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX, 3Baylor University Medical Center, Dallas, TX

    *Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
  • 2022 American Transplant Congress

    Impaired Cellular Immunity and Elevated Myeloid Derived Suppressor Cells in Kidney Transplant Recipients with Impaired Antibody Response to Covid-19 Vaccination

    B. Nibhanupudy1, K. Mcdonald1, M. Angelis1, L. T. Chin1, P. Wai1, R. Metzger1, C. Ashokkumar2, R. Sindhi2

    1AdventHealth Transplant Institute, Orlando, FL, 2Plexision, Inc, Pittsburgh, PA

    *Purpose: To evaluate post-vaccination cellular and antibody (Ab) immunity after COVID-19 vaccination in single blood samples from 17 kidney transplant (KT) recipients who had received…
  • 2022 American Transplant Congress

    Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, B. Lonze1, E. Weldon1, Z. Stewart1, C. DiMaggio1, J. Allen3, S. Gray-Gaillard3, S. Solis3, M. Tuen3, J. Leonard1, R. Montgomery1, R. Herati3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3NYU Langone Health, New York, NY

    *Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
  • 2022 American Transplant Congress

    Safety and Immunogenicity of Live Viral Vaccination After Pediatric Liver and Kidney Transplantation

    A. Feldman1, B. Beaty1, N. Ebel2, J. Ferrolino3, V. Gopalareddy4, J. Hollenbeck5, C. Jaramillo6, N. Kerkar7, S. Lerret8, G. Maron3, A. Mavis9, N. Ovchinsky10, M. Sell11, T. Sharma12, J. Stoll13, L. Danziger-Isakov14

    1UCD, Aurora, CO, 2Stanford, Palo Alto, CA, 3St. Jude, Memphis, TN, 4LCH, Charlotte, NC, 5Michigan Medicine, Ann Arbor, MI, 6PCH, Salt Lake City, UT, 7URMC, Rochester, NY, 8MCW, Milwaukee, WI, 9Duke, Durham, NC, 10Montefiore, NYC, NY, 11MUSC, Charleston, SC, 12BCH, Boston, MA, 13WUSM, St Louis, MO, 14CCHMC, Cincinnati, OH

    *Purpose: New recommendations suggest that measles-mumps-rubella vaccine (MMR-vx) and varicella vaccine (VZV-vx) may be administered to certain non-immune transplant recipients. The purpose of this study…
  • 2022 American Transplant Congress

    Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients

    Y. Natori1, E. Martin2, A. Mattiazzi3, J. Bini Viotti1, K. S. Ortecho4, S. Pallikkuth5, S. Anjan1, J. Simkins1, G. Guerra3

    1Department of Medicine, Division of Infectious Diseases, University of Miami, Miami, FL, 2Department of Medicine, Division of Hepatology, University of Miami, Miami, FL, 3Department of Medicine, Division of Nephrology, University of Miami, Miami, FL, 4Miami Transplant Institute, Jackson Health System, Miami, FL, 5University of Miami, Miami, FL

    *Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…
  • 2022 American Transplant Congress

    Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro10, J. Pawlowska11, P. Czubkowski11, R. Mikolajczyk12, U. Baumann13, C. Falk14

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hôpital Necker-Enfants Malades, Paris, France, 7Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Childrens Hosp, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, 11Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 12Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, 13Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, 14Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
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