ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF

    S. Ghosh1, H. Tedesco2, R. Sarwal1, N. Titzler1, W. Yazar1, M. Nakamura2, J. Pestana2, M. Sarwal1

    1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil

    *Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…
  • 2022 American Transplant Congress

    Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro10, J. Pawlowska11, P. Czubkowski11, R. Mikolajczyk12, U. Baumann13, C. Falk14

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Hannover; Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hannover; Hôpital Necker-Enfants Malades, Paris, France, 7Hannover; Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Children's Hospital, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Ospedali Riuniti di Bergamo, Bergamo, Italy, 11Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 12German Center for Infection Research, TTU-IICH Hannover; MHH; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, 13Birmingham Children’s Hospital, UK; Division of Pediatric Gastroenterology and Hepatology, MHH, Hannover, Germany, 14Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…
  • 2022 American Transplant Congress

    Sars-cov-2 Antibody and T Cell Response After Vaccination with or without Intensified Immunosuppression Among Pediatric Renal Transplant Recipients

    H. Pizzo1, B. Shin2, P. R. Soni3, S. Nadipuram3, J. Garrison2, R. Zhang2, S. C. Jordan2, D. Puliyanda1

    1Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 3Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Recent data has shown poor antibody response to SARS-CoV-2 vaccination among adult kidney transplant (tx) recipients, with seroconversion ranging between 22%-58% after two mRNA…
  • 2022 American Transplant Congress

    Induction of Tolerance After Intestinal Transplantation in a Porcine Model

    S. Merl, R. Jones, B. Chen, M. Sykes, K. Yamada, J. Weiner

    Columbia Center for Translational Immunology, Columbia University, New York, NY

    *Purpose: We describe a case of tolerance from our study investigating multilineage chimerism under immunological conditions after intestinal transplantation using a porcine model with defined…
  • 2022 American Transplant Congress

    Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?

    S. Jacob1, M. L. Baack2, A. Savinov3, P. J. Wettstein4

    1Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, 2Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, 3Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, 4Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN

    *Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
  • 2022 American Transplant Congress

    First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy

    J. Slatinska1, B. Vanhove2, M. Kolarova1, F. Shneiker2, J. Rousse2, C. Galli3, J. Bach4, E. Cozzi5, J. Soulillou6, O. Duvaux2, O. Viklicky1

    1Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Xenothera, Nantes, France, 3Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, 4IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, 5Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, 6Nantes Universités, Nantes, France

    *Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
  • 2022 American Transplant Congress

    MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation

    H. Xu, L. Wang, V. A. Bendersky, Q. Gao, Q. Li, A. D. Kirk, H. Xu

    Duke University School of Medicine, Durham, NC

    *Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…
  • 2022 American Transplant Congress

    Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents

    Y. Sambandam1, J. He1, N. Vanderhyde2, L. Gallon1, J. Leventhal1, J. Mathew1

    1Northwestern University, Chicago, IL, 2IsoPlexis, Branford, CT

    *Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…
  • 2022 American Transplant Congress

    Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets

    R. Matsumoto

    Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan

    *Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
  • 2022 American Transplant Congress

    3D Co-Culture System with Porcine Aortic Endothelial Cell Line and Human or Non-Human Primate Cells for Application in the Study of Xeno-Immune Reaction

    S. K. Yadav1, Y. Lee2, S. Hurh3, S. Kim2, J. Yang4, J. C. Jeong2

    1Medicine, Seoul National University, Seoul, Korea, Republic of, 2Internal Medicine (Nephrology), Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, 3Medicine, Korea University, Seoul, Korea, Republic of, 4Internal Medicine (Nephrology), Yonsei University, Seoul, Korea, Republic of

    *Purpose: Neutrophil Extracellular Trap (NET) is a vigorous immune reaction of neutrophil. It plays role in xenotransplantation rejection. Functional assay of NET is important; however,…
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