ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    Induction of Tolerance After Intestinal Transplantation in a Porcine Model

    S. Merl, R. Jones, B. Chen, M. Sykes, K. Yamada, J. Weiner

    Columbia Center for Translational Immunology, Columbia University, New York, NY

    *Purpose: We describe a case of tolerance from our study investigating multilineage chimerism under immunological conditions after intestinal transplantation using a porcine model with defined…
  • 2022 American Transplant Congress

    Sars-cov-2 Antibody and T Cell Response After Vaccination with or without Intensified Immunosuppression Among Pediatric Renal Transplant Recipients

    H. Pizzo1, B. Shin2, P. R. Soni3, S. Nadipuram3, J. Garrison2, R. Zhang2, S. C. Jordan2, D. Puliyanda1

    1Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 3Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Recent data has shown poor antibody response to SARS-CoV-2 vaccination among adult kidney transplant (tx) recipients, with seroconversion ranging between 22%-58% after two mRNA…
  • 2022 American Transplant Congress

    First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy

    J. Slatinska1, B. Vanhove2, M. Kolarova1, F. Shneiker2, J. Rousse2, C. Galli3, J. Bach4, E. Cozzi5, J. Soulillou6, O. Duvaux2, O. Viklicky1

    1Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Xenothera, Nantes, France, 3Laboratorio di Tecnologie della Riproduzione, Cremone, Italy, 4IECM, Immunoendocrinology, USC1383, Oniris, INRAE, Nantes, France, 5Transplantation Immunology Unit, Padua University Hospital, Padova, Italy, 6Nantes Universités, Nantes, France

    *Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…
  • 2022 American Transplant Congress

    Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?

    S. Jacob1, M. L. Baack2, A. Savinov3, P. J. Wettstein4

    1Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, 2Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, 3Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, 4Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN

    *Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
  • 2022 American Transplant Congress

    Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents

    Y. Sambandam1, J. He1, N. Vanderhyde2, L. Gallon1, J. Leventhal1, J. Mathew1

    1Northwestern University, Chicago, IL, 2IsoPlexis, Branford, CT

    *Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…
  • 2022 American Transplant Congress

    MTOR Inhibition Acts Directly on Endothelial Cells to Induce Contact-Independent Immune-Modulation of Allo-Specific T Cell Activation

    H. Xu, L. Wang, V. A. Bendersky, Q. Gao, Q. Li, A. D. Kirk, H. Xu

    Duke University School of Medicine, Durham, NC

    *Purpose: Endothelial cells (ECs) form a barrier between vascularized organ allografts and host immunity and are known to provoke alloimmune responses. The mTOR inhibitor rapamycin…
  • 2022 American Transplant Congress

    3D Co-Culture System with Porcine Aortic Endothelial Cell Line and Human or Non-Human Primate Cells for Application in the Study of Xeno-Immune Reaction

    S. K. Yadav1, Y. Lee2, S. Hurh3, S. Kim2, J. Yang4, J. C. Jeong2

    1Medicine, Seoul National University, Seoul, Korea, Republic of, 2Internal Medicine (Nephrology), Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, 3Medicine, Korea University, Seoul, Korea, Republic of, 4Internal Medicine (Nephrology), Yonsei University, Seoul, Korea, Republic of

    *Purpose: Neutrophil Extracellular Trap (NET) is a vigorous immune reaction of neutrophil. It plays role in xenotransplantation rejection. Functional assay of NET is important; however,…
  • 2022 American Transplant Congress

    Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets

    R. Matsumoto

    Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan

    *Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
  • 2022 American Transplant Congress

    Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV

    M. Saksena1, G. Carrara2, B. Haydel2, A. Azad1, K. Srivastava1, C. Gleason1, K. Beach1, L. Sominsky1, A. Oostenink1, G. Cai1, J. Carreno Quiroz1, G. Singh1, S. Florman2, C. Cordon-Cardo3, J. Aberg4, A. Wajnberg5, F. Krammer1, V. Simon1, M. Rana4

    1Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, 3Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 4Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 5General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…
  • 2022 American Transplant Congress

    Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept

    J. Mitchell1, J. Alejo1, T. P. Chiang1, J. N. Blankson1, A. H. Karaba1, B. Woldemeskel1, C. Garliss1, A. Chang1, A. Abedon1, R. K. Avery1, A. Tobian1, A. B. Massie1, J. Garonzik-Wang2, D. L. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin, Madison, WI

    *Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…
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