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Articles tagged "Immunogenicity"

  • 2022 American Transplant Congress

    Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation

    S. Vasu1, C. Darden2, J. Mattke2, Y. Liu3, M. C. Lawrence3, B. Naziruddin1

    1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX, 3Baylor University Medical Center, Dallas, TX

    *Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
  • 2022 American Transplant Congress

    Impaired Cellular Immunity and Elevated Myeloid Derived Suppressor Cells in Kidney Transplant Recipients with Impaired Antibody Response to Covid-19 Vaccination

    B. Nibhanupudy1, K. Mcdonald1, M. Angelis1, L. T. Chin1, P. Wai1, R. Metzger1, C. Ashokkumar2, R. Sindhi2

    1AdventHealth Transplant Institute, Orlando, FL, 2Plexision, Inc, Pittsburgh, PA

    *Purpose: To evaluate post-vaccination cellular and antibody (Ab) immunity after COVID-19 vaccination in single blood samples from 17 kidney transplant (KT) recipients who had received…
  • 2022 American Transplant Congress

    Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, B. Lonze1, E. Weldon1, Z. Stewart1, C. DiMaggio1, J. Allen3, S. Gray-Gaillard3, S. Solis3, M. Tuen3, J. Leonard1, R. Montgomery1, R. Herati3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3NYU Langone Health, New York, NY

    *Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
  • 2022 American Transplant Congress

    Safety and Immunogenicity of Live Viral Vaccination After Pediatric Liver and Kidney Transplantation

    A. Feldman1, B. Beaty1, N. Ebel2, J. Ferrolino3, V. Gopalareddy4, J. Hollenbeck5, C. Jaramillo6, N. Kerkar7, S. Lerret8, G. Maron3, A. Mavis9, N. Ovchinsky10, M. Sell11, T. Sharma12, J. Stoll13, L. Danziger-Isakov14

    1UCD, Aurora, CO, 2Stanford, Palo Alto, CA, 3St. Jude, Memphis, TN, 4LCH, Charlotte, NC, 5Michigan Medicine, Ann Arbor, MI, 6PCH, Salt Lake City, UT, 7URMC, Rochester, NY, 8MCW, Milwaukee, WI, 9Duke, Durham, NC, 10Montefiore, NYC, NY, 11MUSC, Charleston, SC, 12BCH, Boston, MA, 13WUSM, St Louis, MO, 14CCHMC, Cincinnati, OH

    *Purpose: New recommendations suggest that measles-mumps-rubella vaccine (MMR-vx) and varicella vaccine (VZV-vx) may be administered to certain non-immune transplant recipients. The purpose of this study…
  • 2022 American Transplant Congress

    Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients

    Y. Natori1, E. Martin2, A. Mattiazzi3, J. Bini Viotti1, K. S. Ortecho4, S. Pallikkuth5, S. Anjan1, J. Simkins1, G. Guerra3

    1Department of Medicine, Division of Infectious Diseases, University of Miami, Miami, FL, 2Department of Medicine, Division of Hepatology, University of Miami, Miami, FL, 3Department of Medicine, Division of Nephrology, University of Miami, Miami, FL, 4Miami Transplant Institute, Jackson Health System, Miami, FL, 5University of Miami, Miami, FL

    *Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…
  • 2022 American Transplant Congress

    Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro10, J. Pawlowska11, P. Czubkowski11, R. Mikolajczyk12, U. Baumann13, C. Falk14

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover;Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hôpital Necker-Enfants Malades, Paris, France, 7Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Childrens Hosp, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Pediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy, 11Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 12Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle; German Center for Infection Research, TTU-IICH Hannover; MHH, Halle, Germany, 13Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK, Hannover, Germany, 14Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
  • 2022 American Transplant Congress

    Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach

    H. Tejeda Mora1, J. Willemse2, Y. den Hartog1, I. Schurink2, M. M. Verstegen2, J. de Jonge2, R. C. Minnee2, M. W. van den Hoogen2, C. C. Baan1, L. J. van der Laan2, M. J. Hoogduijn1

    1Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 2Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
  • 2022 American Transplant Congress

    Immunogenicity of a Quadrivalent Human Papillomavirus Vaccine in Pediatric Kidney and Liver Transplant Recipients

    T. Kitano1, K. Schwartz2, M. Abdulnoor1, H. Garfield3, N. K. Booran1, Y. Avitzur1, C. Teoh1, D. Hebert4, U. Allen3

    1Hospital for Sick Children, Toronto, ON, Canada, 2Public Health Ontario, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Solid-organ transplant recipients are at increased risk of developing human papillomavirus (HPV)-related diseases. The immunogenicity of HPV vaccine for solid-organ transplant population needs further…
  • 2022 American Transplant Congress

    Additional Dose of SARS-CoV-2 Vaccine Increases Neutralization Capacity in Solid Organ Transplant Recipients

    Y. Yoo1, J. Husson2, T. Iraguha3, S. Niederhaus4, X. Wen5, A. Crane5, A. Carrier5, J. Avruch5, A. Ahuja6, M. Mathew7, S. Dahiya8, A. P. Rapoport8, D. Atanackovic8, K. K. Saharia2

    1Inst of Human Virology, Baltimore, MD, 2Div of Infect Diseases, Univ of Maryland School of Med. and Inst of Human Virology, Baltimore, MD, 3Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD, 4Dept of Surgery, Univ of Maryland School of Med., Baltimore, MD, 5Dept of Surgery, Univ of Maryland Med. Center, Baltimore, MD, 6Dept of Medicine, Univ of Maryland Med. Center, Baltimore, MD, 7Div of Infect. Diseases, Univ of Maryland Med. Center, Baltimore, MD, 8Dept of Medicine, Univ of Maryland School of Med. and Greenebaum Comprehensive Cancer Center, Baltimore, MD

    *Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection,…
  • 2022 American Transplant Congress

    Identification of Soluble and Cellular Biomarkers in Blood of End-Stage Patients Before Pediatric Liver Transplantation (pLTx)

    E. Chichelnitskiy1, L. Ruhl2, I. Goldschmidt3, A. Karch4, L. Antiga5, D. Debray6, L. Hierro7, D. Kelly8, V. McLin9, E. Nicastro5, J. Pawlowska10, R. Mikolajczyk11, U. Baumann12, C. Falk13

    1Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, 2Institute of Transplant Immunology, MHH, Hannover, Germany, 3Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, 4Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, 5Ospedali Riuniti di Bergamo, Bergamo, Italy, 6Hôpital Necker-Enfants Malades, Paris, France, 7Hospital Infantil Universitario La Paz, Madrid, Spain, 8Birmingham Children's Hospital, Birmingham, United Kingdom, 9Service Spécialités Pédiatriques, Genève, Switzerland, 10Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, 11German Center for Infection Research, TTU-IICH Hannover; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, 12Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK; European Paediatric Liver Transplantation Network, Hannover, Germany, 13Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany

    *Purpose: In the European multicentre “ChilSFree” study we aimed to identify soluble and cellular biomarkers in blood of various end-stage diseases before pLTx.*Methods: Using flow…
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