Articles tagged "Immunogenicity"

2022 American Transplant Congress
Humoral and Cellular Immune Response to a Third Dose Of SARS-CoV-2 Vaccine in Kidney Transplant Recipients on Belatacept
J. Mitchell¹, J. Alejo¹, T. P. Chiang¹, J. N. Blankson¹, A. H. Karaba¹, B. Woldemeskel¹, C. Garliss¹, A. Chang¹, A. Abedon¹, R. K. Avery¹, A. Tobian¹, A. B. Massie¹, J. Garonzik-Wang², D. L. Segev¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin, Madison, WI
*Purpose: Kidney transplant recipients taking belatacept (KTR-B) have poor immune response to two-dose SARS-CoV-2 vaccination. We sought to characterize the impact of an additional vaccine…
2022 American Transplant Congress
Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV
M. Saksena¹, G. Carrara², B. Haydel², A. Azad¹, K. Srivastava¹, C. Gleason¹, K. Beach¹, L. Sominsky¹, A. Oostenink¹, G. Cai¹, J. Carreno Quiroz¹, G. Singh¹, S. Florman², C. Cordon-Cardo³, J. Aberg⁴, A. Wajnberg⁵, F. Krammer¹, V. Simon¹, M. Rana⁴
¹Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, ³Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…
2022 American Transplant Congress
An Additional Dose Of Viral Vector Covid-19 Vaccine And Mrna Covid-19 Vaccine In Kidney Transplant Recipients: A Randomized Controlled Trial
J. Bruminhent¹, C. Setthaudom², P. Phornkittikorn³, P. Chaumdee³, S. Prasongtanakij⁴, S. Srisala⁴, K. Malathum¹, S. Boongird⁵, A. Nongnuch⁵, M. Assanatham⁵, S. Kiertiburanakul¹
¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ²Immunology Laboratory, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ³Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ⁴Office of Research, Academic Affairs and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, ⁵Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
*Purpose: An additional dose of the COVID-19 vaccine following a primary series is recommended for solid organ transplant recipients. However, a comparison of the immunogenicity…
2022 American Transplant Congress
Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration
N. M. Ali¹, S. Mehta¹, V. Tatapudi¹, A. Mattoo¹, I. Soomro¹, J. Benstein¹, H. Neumann¹, F. Zervou¹, J. Miles², R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, CA
*Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
2022 American Transplant Congress
Differences in Strength and Longevity of SARS-CoV-2-Specific Adaptive Immunity Between Convalescent and Vaccinated SOT Patients and Immunocompetent Individuals
L. Donadeu¹, S. Gomez¹, A. Fava'², E. Crespo¹, F. Moreso³, M. Lopez³, L. Lladó⁴, J. González⁴, I. Campos³, M. Muñoz³, J. Quintero³, J. Esperalba³, O. Bestard³
¹Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ²Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ³Vall d’Hebron University Hospital (HUVH), Barcelona, Spain, ⁴Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain
*Purpose: Short-term adaptive immune memory has been reported among immunocompetent (IC) and convalescent Solid Organ Transplant (SOT) individuals following SARS-CoV-2 infection as well as after…
2022 American Transplant Congress
Immunogenicity and Safety of SARS-CoV-2 Vaccines and Breakthrough Infections Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis
A. Villavicencio¹, Y. Ebisu², M. Raja³, A. P. Sanchez-Covarrubias¹, S. Anjan³, J. M. Reynolds¹, J. Simkins³, J. Camargo³, M. I. Morris³, L. Abbo⁴, G. Guerra⁵, Y. Natori⁶
¹Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, ²Kameda Medical Center, Chiba, Japan, ³University of Miami Miller School of Medicine, Miami, FL, ⁴University Of Miami Miller School of Medicine, Miami, FL, ⁵University of Miami Jackson Memorial Hospital, Miami, FL, ⁶University of Miami, Pinecrest, FL
*Purpose: The SARS-CoV-2 pandemic has had a significant impact on the field of solid organ transplant(SOT). Immunization against SARS-CoV-2 is globally available since 2021. SOT…
2022 American Transplant Congress
Islet-Derived Exosomes Carry Self-Antigens and May Induce Autoimmunity After Transplantation
S. Vasu¹, C. Darden², J. Mattke², Y. Liu³, M. C. Lawrence³, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³Baylor University Medical Center, Dallas, TX
*Purpose: Our earlier observations revealed release of exosomes from human islets containing microRNAs (miRNA) specific to islet stress and damage in vitro and in vivo…
2022 American Transplant Congress
Impaired Cellular Immunity and Elevated Myeloid Derived Suppressor Cells in Kidney Transplant Recipients with Impaired Antibody Response to Covid-19 Vaccination
B. Nibhanupudy¹, K. Mcdonald¹, M. Angelis¹, L. T. Chin¹, P. Wai¹, R. Metzger¹, C. Ashokkumar², R. Sindhi²
¹AdventHealth Transplant Institute, Orlando, FL, ²Plexision, Inc, Pittsburgh, PA
*Purpose: To evaluate post-vaccination cellular and antibody (Ab) immunity after COVID-19 vaccination in single blood samples from 17 kidney transplant (KT) recipients who had received…
2022 American Transplant Congress
Antibody Response and Cellular Phenotyping in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, B. Lonze¹, E. Weldon¹, Z. Stewart¹, C. DiMaggio¹, J. Allen³, S. Gray-Gaillard³, S. Solis³, M. Tuen³, J. Leonard¹, R. Montgomery¹, R. Herati³
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY, ³NYU Langone Health, New York, NY
*Purpose: Correlates of protection for SARS-CoV-2 vaccines are not well-established in kidney transplant recipients(KTRs). Studies have highlighted the importance of neutralizing antibodies(Abs), however data suggests…
2022 American Transplant Congress
Safety and Immunogenicity of Live Viral Vaccination After Pediatric Liver and Kidney Transplantation
A. Feldman¹, B. Beaty¹, N. Ebel², J. Ferrolino³, V. Gopalareddy⁴, J. Hollenbeck⁵, C. Jaramillo⁶, N. Kerkar⁷, S. Lerret⁸, G. Maron³, A. Mavis⁹, N. Ovchinsky¹⁰, M. Sell¹¹, T. Sharma¹², J. Stoll¹³, L. Danziger-Isakov¹⁴
¹UCD, Aurora, CO, ²Stanford, Palo Alto, CA, ³St. Jude, Memphis, TN, ⁴LCH, Charlotte, NC, ⁵Michigan Medicine, Ann Arbor, MI, ⁶PCH, Salt Lake City, UT, ⁷URMC, Rochester, NY, ⁸MCW, Milwaukee, WI, ⁹Duke, Durham, NC, ¹⁰Montefiore, NYC, NY, ¹¹MUSC, Charleston, SC, ¹²BCH, Boston, MA, ¹³WUSM, St Louis, MO, ¹⁴CCHMC, Cincinnati, OH
*Purpose: New recommendations suggest that measles-mumps-rubella vaccine (MMR-vx) and varicella vaccine (VZV-vx) may be administered to certain non-immune transplant recipients. The purpose of this study…

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