Articles tagged "HLA antibodies"

2016 American Transplant Congress
Antibody Titers as Predictors of Kidney Graft Outcomes.
A. Gilbert,¹ M. Zaheer,¹ O. Timofeeva,² S. Rosen-Bronson,² M. Awwad,² D. Li,² M. Grafals,¹ B. Javaid,¹ P. Abrams,¹ J. Verbesey,¹ M. Cooper.¹
¹Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
PURPOSE: Development of de novo donor specific antibody (dnDSA) following kidney transplantation is not uncommon. As laboratory techniques advance, rates of dnDSA have increased. However,…
2016 American Transplant Congress
Impact of C3d and C1q-Binding DSA Detected Long-Term After Kidney Transplantation.
M. Crespo,^1,2 D. Redondo,^1,2 C. Garcia,³ J. Gimeno,⁴ M. Perez,^1,2 M. Mir,¹ J. Hernandez,³ J. Yelamos,² A. Faura,^1,2 J. Pascual.^1,2
¹Nephrology and Transplant, Hospital del Mar, Barcelona, Spain; ²Medical Research Institute (IMIM), Hospital del Mar, Barcelona, Spain; ³Catalunya Reference Laboratory, Barcelona, Spain; ⁴Pathology, Hospital del Mar, Barcelona, Spain.
HLA DSA detected after kidney transplantation(KT) correlate with outcome, but not all are equal and produce the same functional consequences. Early complement-binding DSA were asssociated…
2016 American Transplant Congress
Outcomes from De Novo Tacrolimus Weight-Based Dosing Compared to Conservative Dosing in Kidney Transplant Recipients.
B. Summers,² K. Szempruch,¹ M. Harris,² A. Quidley,¹ C. Haisch,¹ A. Maldonado.¹
¹Vidant Medical Center/East Carolina University, Greenville, NC; ²Duke University Hospital, Durham, NC.
Purpose: To compare de novo tacrolimus (TAC) weight based dosing (WDG) and conservative dosing (CDG) on incidence and duration of DGF in adult kidney transplant…
2016 American Transplant Congress
Complement-Binding Donor-Specific Anti-HLA Antibodies Are Associated with Severe Kidney Allograft Arteriosclerosis.
A. Loupy,¹ D. Viglietti,² J. Duong Van Huyen,¹ D. Glotz,² C. Legendre,¹ A. Zeevi,³ C. Lefaucheur.²
¹Necker Hospital, Paris, France; ²Saint-Louis Hospital, Paris, France; ³University of Pittsburgh Medical Center, Pittsburgh.
The role of circulating donor-specific anti-HLA antibodies (DSA) in the development of accelerated arteriosclerosis have been recently reported in kidney transplant recipients. This study investigated…
2016 American Transplant Congress
Donor HLA Specific IgM Antibody Measured on Day 14 Post-Transplantation Predicts Poor Graft Survival in HLA-Incompatible Renal Transplantation.
A. Babu, A. Androeu, S. Daga, R. Higgins, D. Mitchell, D. Briggs, N. Khovanova, N. Krishnan.
Renal Medicine, University Hospital Coventry and Warwickshire, Coventry, West Midlands, United Kingdom; Life Sciences, University of Warwick, Coventry, West Midlands, United Kingdom; Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, West Midlands, United Kingdom; School of Engineering, University of Warwick, Coventry, United Kingdom.
Introduction: Role of IgG antibodies against donor human leucocyte antigens (HLA) is established in renal transplant monitoring. Role of IgM donor HLA specific antibodies (DSA)…
2016 American Transplant Congress
Baseline Donor Specific Antibody (DSA) More Predictive of Chronic Antibody Mediated Rejection (CAMR) Than the Change in DSA Over Time.
D. Mitema,¹ W. Cheungpasitporn,¹ M. Stegall,¹ F. Cosio,¹ M. Gandhi,² C. Schinstock.¹
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Division of Transfusion Medicine, Mayo Clinic, Rochester, MN.
Introduction: Although therapies are available to at least temporarily reduce DSA, the change in DSA naturally post-transplant remains unknown. We aim to study the serial…
2016 American Transplant Congress
Role of Preformed IgM Donor Human Leucocyte Antigen (HLA) Specific Antibodies in HLA Incompatible Renal Transplantation.
A. Andreou, A. Babu, T. Barber, R. Higgins, D. Briggs, D. Mitchell, N. Khovanova, T. Shaikhina, S. Daga.
Renal, University Hospitals Coventry and Wawickshire, Coventry, United Kingdom; Life Sciences, University of Warwick, Coventry, United Kingdom; School of Mathematics and Engineering, University of Warwick, Coventry, United Kingdom.
Introduction: Pre-transplant IgG antibody screening is common due to its established role of predicting rejection and graft survival; the role of pre-formed IgM human leukocyte…
2016 American Transplant Congress
Initial Experience with the Bacterial Enzyme IdeS® (IgG Endopeptidase) for Desensitization of Highly-HLA Sensitized (HS) Patients.
S. Jordan,¹ J. Choi,¹ X. Zhang,¹ M. Haas,² A. Peng,¹ J. Kahwaji,¹ R. Villicana,¹ A. Vo.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: The IgG degrading enzyme derived from Streptococcus pyogenes (IdeS®) is a 35k-Da cysteine protease that cleaves human IgG molecules at the lower hinge region…
2016 American Transplant Congress
Clinical Significance of Non-HLA Antibodies in the Development of Microcirculation Inflammation in Allograft Tissue After Kidney Transplantation.
J. Min,^1,3 H. Lee,^2,3 B. Chung,^1,3 E.-J. Oh,^2,3 C. Yang.^1,3
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; ²Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; ³Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
The aim of our study is to determine the clinical significance of pre-transplant non-HLA antibodies, mainly those targeting the angiotenin II type I receptor (AT1R)…
2016 American Transplant Congress
Comparison of Efficacy and Safety of a 4-Month Post-Renal Transplant Dose Reduction of Tacrolimus.
P. Gatault,¹ N. Kamar,² M. Buchler,¹ C. Colosio,³ D. Bertrand,⁴ A. Durrbach,⁵ L. Albano,⁶ J. Rivalan,⁷ M. Essig,⁸ Y. Le Meur,⁹ N. Bouvier,¹⁰ B. Charpentier,⁵ E. Thervet,¹¹ L. Rostaing,² Y. Lebranchu.¹
¹Service de Transplantation rénale, CHRU, Tours, France; ²Service de Transplantation Rénale, CHU, Toulouse, France; ³Service de Transplantation Rénale, CHU, Reims, France; ⁴Service Transplantation Rénale, CHU, Rouen, France; ⁵Service de Transplantation Rénale, APHP, Kremlin Bicêtre, France; ⁶Service de Transplantation Rénale, CHU, Nice, France; ⁷Service de Transplantation Rénale, CHU, Rennes, France; ⁸Service de Transplantation Rénale, CHU, Limoges, France; ⁹Service de Transplantation Rénale, CHU, Brest, France; ¹⁰Service de Transplantation Rénale, CHU, Caen, France; ¹¹Service de Néphrologie, APHP, Centre Européen Georges Pompidou, Boulogne-Billancourt, France.
Introduction. The aim of the study was to determine the efficacy and safety balance of 2 different doses of tacrolimus extended-release (TacER) in kidney transplant…