Clinical Significance of Non-HLA Antibodies in the Development of Microcirculation Inflammation in Allograft Tissue After Kidney Transplantation.
1Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
3Transplant Research Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Meeting: 2016 American Transplant Congress
Abstract number: 58
Keywords: HLA antibodies, Kidney transplantation, Rejection
Session Information
Date: Sunday, June 12, 2016
Session Name: Concurrent Session: Novel Markers of Long Term Kidney Transplant Outcomes
Session Time: 2:30pm-4:00pm
Presentation Time: 3:06pm-3:18pm
Location: Ballroom A
The aim of our study is to determine the clinical significance of pre-transplant non-HLA antibodies, mainly those targeting the angiotenin II type I receptor (AT1R) and major histocompatibility complex class I-related chain A (MICA). We examined the presence of pre-transplant AT1R and MICA antibodies in 362 patients who underwent kidney transplantation. Patients were divided into groups according to the presence of AT1R and MICA antibodies: MICA only (n=28), AT1R only (n=150), MICA– +AT1R– (n=159), MICA+ +AT1R+ (n=22) groups. Clinical characteristics and immunological characteristics were compared among these groups. Patients who underwent post-transplant allograft biopsy (indicated biopsy for elevated creatinine (n=128) and protocol biopsy (n=124)) were further divided according to the presence of pre-transplant HLA-DSA, and pathologic biopsy findings and clinical outcomes were compared among groups. There were no significant differences among the groups in baseline clinical and immunological characteristics. In biopsy findings, no significant differences were found in the development of AMR, but microvascular inflammation (glomerulitis + peritubular capillaritis) scores, representing humoral immunity, were significantly higher in the MICA or AT1R detected groups compared to groups without either antibodies (P<0.05). These findings were consistent in both indicated and protocol biopsy patients, especially in those without detectable HLA-DSA. Allograft survival was also significantly lower in patients positive for either MICA or AT1R antibodies, but negative for HLA-DSA (P<0.05). In conclusion, pre-transplant detection of MICA or AT1R antibody is significantly associated with the post-transplant development of microcirculation inflammation and poor allograft outcomes especially in those without HLA-DSA.
CITATION INFORMATION: Min J, Lee H, Chung B, Oh E.-J, Yang C. Clinical Significance of Non-HLA Antibodies in the Development of Microcirculation Inflammation in Allograft Tissue After Kidney Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Min J, Lee H, Chung B, Oh E-J, Yang C. Clinical Significance of Non-HLA Antibodies in the Development of Microcirculation Inflammation in Allograft Tissue After Kidney Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/clinical-significance-of-non-hla-antibodies-in-the-development-of-microcirculation-inflammation-in-allograft-tissue-after-kidney-transplantation/. Accessed April 3, 2020.« Back to 2016 American Transplant Congress