Articles tagged "Histology"

2016 American Transplant Congress
Natural Language Processing Methods Allow Reliable Extraction of Banff Scores and Grades.
K. Reilly,¹ L. Lenert,¹ H. Anwar,² J. Thompson,¹ D. Taber,¹ P. Mauldin,¹ T. Srinivas.¹
¹MUSC, Charleston; ²IBM, NY.
Objective: National Data are sparse with regard to pathology of rejection. Incorporating biopsy pathology grades and lesion scores into analyses requires manual extraction and entry…
2016 American Transplant Congress
Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.
S. Yilmaz,¹ D. Shaffer,² Y. Qazi,³ F. Shihab,⁴ K. McCague,⁵ D. Patel,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Southern California, Los Angeles, CA; ⁴University of Utah, Salt Lake City, UT; ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁶University of California San Francisco, San Francisco, CA.
Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
2016 American Transplant Congress
The Effect of Everolimus and Tacrolimus Exposure Levels on Renal Histology Parameters 6 Months Post-Transplantation.
S. Yilmaz,¹ D. Shaffer,² Y. Qazi,³ K. McCague,⁴ D. Patel,⁴ V. Peddi,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, Canada; ²Vanderbilt University, Nashville; ³University of Southern California, Los Angeles; ⁴Novartis Pharmaceuticals Corporation, East Hanover; ⁵California Pacific Medical Center, San Francisco; ⁶University of California San Francisco, San Francisco.
We examined renal histology scores in patients with different exposure levels of everolimus (EVR) and tacrolimus (TAC) over 6 months.Renal transplant patients (N=613) were randomized…
2016 American Transplant Congress
Using Gastrointestinal Biopsy to Predict Outcome in Patients Evaluated for Cardiac Transplantation for Amyloidosis: A Report from the International Consortium on Cardiac Amyloidosis Transplantation (iCCAT).
Y. Li,¹ K. Verkouw,¹ S. Tabtabai,¹ R. Barrios,² R. Gill,³ J. Koo,⁴ C. Marboe,⁵ E. Rodriguez,⁶ C. Tan,⁶ T. De Marco,³ J. Estep,² M. Hanna,⁶ M. Maurer,⁵ J. Patel,⁴ V. Selby,³ M. Semigran,¹ J. Stone.¹
¹Massachusetts General Hospital, Boston, MA; ²The Methodist Hospital, Houston, TX; ³University of California San Francisco, San Francisco, CA; ⁴Cedars-Sinai Heart Institute, Los Angeles, CA; ⁵Columbia University Medical Center, New York, NY; ⁶Cleveland Clinic, Cleveland, OH.
Heart transplant (HT) is an established therapy for heart failure due to amyloidosis. The utility of gastrointestinal (GI) biopsy in predicting patient outcomes and guiding…
2016 American Transplant Congress
Plasma Cell Frequency in Renal Rejection After Treatment with Alemtuzumab.
L. Mugge, A. Zimmerman, N. Varshney, A. Gohara, M. Rees, J. Ortiz.
Transplantation, The University of Toledo, Toledo, OH.
Background: The highly successful induction drug Alemtuzumab (Campath) is commonly used prior to renal transplant. Yet, it does not completely ablate plasma cell which, in…
2016 American Transplant Congress
Don't Judge a Book by Its Cover: Normal Liver Enzymes After Transplantation Can Be Associated with Pathologies Requiring Intervention.
C. Sanchez,¹ S. Kumer,² S. Olson,¹ R. Gilroy,¹ T. Schmitt,² B. Kane,² R. Taylor.¹
¹Hepatology/Transplant, University of Kansas, Kansas City, KS; ²Surgery, University of Kansas, Kansas City, KS.
Background:Liver biopsies are employed post-transplant generally to evaluate abnormal liver enzymes (LE); however they are not without risk. Whether post-transplant protocol biopsies (PB) serve any…
2016 American Transplant Congress
Digital Kidney Biopsy Evaluation: Quantification of Macrophage Prevalence in a Cross Sectional Study.
J. Schmitz,¹ A. Khalifa,¹ H. Haller,² H. Kreipe,¹ F. Feuerhake,¹ J. Bräsen.¹
¹Institute of Pathology, Hannover Medical School, Hannover, Germany; ²Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Standardized markers based on quantitative and qualitative evaluation of immune cell mass and localization in kidney biopsies may help in diagnosis and prognosis in transplantation…
2016 American Transplant Congress
The Impact of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx) Is Independent of Time Post-Transplant.
R. Gaston,¹ J. Grande,² R. Leduc,³ The DeKAF Study Group.
¹Dept. of Medicine, University of Alabama at Birmingham, Birmingham, AL; ²Dept of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ³Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.
Detection of MVI in a KTxBx, often associated with antibody mediated rejection, is associated with a poor prognosis for kidney graft survival. However most information…
2016 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.
W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medicine, Baltimore, MD.
Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
2016 American Transplant Congress
Treatment of Post-Transplant Focal Glomerulosclerosis: The Effect on Histopathology Lesions and Podocyte Foot Process Effacement.
K. Koutroutsos,¹ J. Moss,² L. Moran,² T. Cook,² R. Charif,¹ D. Taube,¹ C. Roufosse,² M. Loucaidou.¹
¹Renal and Transplant Centre, Imperial Healthcare NHS Trust, London, United Kingdom; ²Department of Histopathology, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Post-transplant Focal Segmental Glomerulosclerosis (FSGS) is associated with increased risk for renal allograft failure. It has been reported in the literature that podocyte foot…