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Articles tagged "Histology"

  • 2016 American Transplant Congress

    Don't Judge a Book by Its Cover: Normal Liver Enzymes After Transplantation Can Be Associated with Pathologies Requiring Intervention.

    C. Sanchez,1 S. Kumer,2 S. Olson,1 R. Gilroy,1 T. Schmitt,2 B. Kane,2 R. Taylor.1

    1Hepatology/Transplant, University of Kansas, Kansas City, KS; 2Surgery, University of Kansas, Kansas City, KS.

    Background:Liver biopsies are employed post-transplant generally to evaluate abnormal liver enzymes (LE); however they are not without risk. Whether post-transplant protocol biopsies (PB) serve any…
  • 2016 American Transplant Congress

    Digital Kidney Biopsy Evaluation: Quantification of Macrophage Prevalence in a Cross Sectional Study.

    J. Schmitz,1 A. Khalifa,1 H. Haller,2 H. Kreipe,1 F. Feuerhake,1 J. Bräsen.1

    1Institute of Pathology, Hannover Medical School, Hannover, Germany; 2Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

    Standardized markers based on quantitative and qualitative evaluation of immune cell mass and localization in kidney biopsies may help in diagnosis and prognosis in transplantation…
  • 2016 American Transplant Congress

    The Impact of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx) Is Independent of Time Post-Transplant.

    R. Gaston,1 J. Grande,2 R. Leduc,3 The DeKAF Study Group.

    1Dept. of Medicine, University of Alabama at Birmingham, Birmingham, AL; 2Dept of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 3Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    Detection of MVI in a KTxBx, often associated with antibody mediated rejection, is associated with a poor prognosis for kidney graft survival. However most information…
  • 2016 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.

    W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medicine, Baltimore, MD.

    Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
  • 2016 American Transplant Congress

    Treatment of Post-Transplant Focal Glomerulosclerosis: The Effect on Histopathology Lesions and Podocyte Foot Process Effacement.

    K. Koutroutsos,1 J. Moss,2 L. Moran,2 T. Cook,2 R. Charif,1 D. Taube,1 C. Roufosse,2 M. Loucaidou.1

    1Renal and Transplant Centre, Imperial Healthcare NHS Trust, London, United Kingdom; 2Department of Histopathology, Imperial Healthcare NHS Trust, London, United Kingdom.

    Background: Post-transplant Focal Segmental Glomerulosclerosis (FSGS) is associated with increased risk for renal allograft failure. It has been reported in the literature that podocyte foot…
  • 2016 American Transplant Congress

    Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).

    J. Grande,1 R. Leduc,2 The DeKAF Study Group.

    1Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; 2Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.

    The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
  • 2016 American Transplant Congress

    Clinical, Histologic and Charge Endpoints When Populations with Hepatitis C Recurrence Are Treated with Direct-Acting Antiviral or Interferon Based Therapies.

    S. Olson, A. McCann, S. Kumer, T. Schmitt, B. Floyd, R. Taylor, R. Gilroy.

    University of Kansas, Kansas City, KS.

    Background: While the primary endpoint for patients transplanted for Hepatitis C (HCV) has been established as sustained virologic response (SVR), different pathways have existed to…
  • 2016 American Transplant Congress

    Complexity of Hylinosis in Renal Transplant Biopsies: Donor Age, Glomerular Disease, and Time.

    G. Einecke,1 J. Reeve,2 P. Halloran.2,3

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Alberta Transplant Applied Genomics Centre, Edmonton, Canada; 3Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, Canada.

    Arteriolar hyalinosis lesions (ah) are often interpreted as a sign of calcineurin inhibitor toxicity even though they are induced by other conditions. We studied the…
  • 2016 American Transplant Congress

    The Treatment of Borderline Lesion in Protocol Biopsies Did Not Improve the Outcome in Kidney Transplant Recipients.

    A. Flores-Mendoza, L. Marino-Vazquez, A. Guichard-Romero, N. Uribe-Uribe, R. Rivera-Marfil, A. Nuñez-Abreu, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation and Pathology, National Institute of Medical Sciences and Nutrition SZ, Mexico, Distrito Federal, Mexico.

    Introduction. Up to 30% of patients with protocol biopsies and stable renal function have borderline lesions. His relationship with acute rejection remains uncertain, as does…
  • 2016 American Transplant Congress

    Lower Renal Graft Function and Accelerated Fibrosis in HIV-Infected Transplant Recipients with Previous HIVAN Compared to Non HIVAN HIV-Positive Transplant Recipients.

    M.-N. Peraldi,1 H. Ayari,1 M. Burbach,1 C. Randoux,2 E. Pillebout,1 N. De Castro,3 J.-M. Molina,3 D. Glotz.1

    1Nephrologie et Transplantation, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France; 2Néphrologie, Hôpital Bichat et Université Paris-Diderot, Paris, France; 3Service de Maladies Infectieuses, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France.

    Several studies reported reduced renal allograft survival rates among HIV-infected transplant recipients. Few data focus on histological lesions and their progression in renal grafts from…
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