ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2020 American Transplant Congress

    Efficacy of Radiofrequency Ablation in the Treatment of Patients with Hepatocellular Carcinoma and Compensated Liver Disease: A Pathological Evaluation of Liver Explants

    W. Alhamoudi1, I. Salih2, S. Yousif2, M. Shawkat3, K. Bzeizi2, A. Albenmousa2, S. Alghamdi2, M. Sturdevant2, D. Broering2, H. Alsuhaibani2

    1Medicine, King Saud University, Riyadh, Saudi Arabia, 2Liver Transplant, King Faisal Specialist Hospital, Riyadh, Saudi Arabia, 3Internal Medicine, Minia University, Minia, Egypt

    *Purpose: Radiofrequency ablation (RFA) is a safe and effective treatment for patients with limited hepatocellular carcinoma (HCC). Ablative outcomes have been largely based on radiological…
  • 2020 American Transplant Congress

    The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA

    M. Coemans1, A. Senev1, G. Verbeke2, M. Emonds1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium

    *Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
  • 2020 American Transplant Congress

    The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants

    D. Rychkov

    Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA

    *Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…
  • 2020 American Transplant Congress

    Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation

    A. Bentall1, C. Heybeli2, F. G. Cosio1, M. El Ters1, N. Leung1, M. P. Alexander3

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 2Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

    *Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…
  • 2020 American Transplant Congress

    Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, L. Kamal1, A. King1, L. Kang1, M. Levy1, S. Bobba1, D. Massey1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
  • 2020 American Transplant Congress

    Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy

    V. Kung1, M. Haas1, M. Gillespie2, E. Huang2, R. Sandhu2

    1Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
  • 2020 American Transplant Congress

    Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation

    A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall

    Mayo Clinic, Rochester, Rochester, MN

    *Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
  • 2020 American Transplant Congress

    Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?

    C. M. Edwards1, J. T. Langford1, M. Reschke2, J. R. DiRito1, D. Mulligan1, D. Haakinson1, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT

    *Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
  • 2020 American Transplant Congress

    Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection

    E. Peyster1, S. ArabYarmohommadi2, A. Janowczyk2, M. Sekulic3, C. Cassol4, M. Feldman1, K. Margulies1, A. Madabhushi2

    1University of Pennsylvania, Philadelphia, PA, 2Case Western Reserve University, Cleveland, OH, 3University Hospitals Cleveland Medical Center, Cleveland, OH, 4Ohio State University, Columbus, OH

    *Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
  • 2020 American Transplant Congress

    Effects of Mandatory 6-Month Waiting Time Policy on Post-Transplant Outcomes and Explant Pathology in Liver Transplant Patients with Hepatocellular Carcinoma

    S. Nagai, T. Kitajima, S. Yeddula, R. Salgia, M. Abouljoud, D. Moonka

    Henry Ford Hospital, Detroit, MI

    *Purpose: In the United States, current allocation policy mandates a 6-month waiting period before exception scores are granted to liver transplant (LT) candidates with hepatocellular…
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