ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2022 American Transplant Congress

    Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers

    V. Fleetwood1, D. Axelrod2, Y. Caliskan1, H. Randall1, J. Wellen3, M. Lichtenberger3, C. Dedert1, R. Rothweiler4, G. F. Marklin4, D. Brockmeier4, M. A. Schnitzler1, S. A. Husain5, S. Mohan5, B. Kasiske6, M. Cooper7, K. L. Lentine1

    1Saint Louis U., St. Louis, MO, 2U. of Iowa, Iowa City, IA, 3WUSTL, St. Louis, MO, 4Mid-Am. Trans., St. Louis, MO, 5Columbia U., New York, NY, 6Hennepin Healthcare, Minneapolis, MN, 7MedStar Transpl. Inst., Washington, DC

    *Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
  • 2022 American Transplant Congress

    Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient

    O. C. Onuh1, J. Trilles1, W. J. Rifkin1, H. Brydges1, B. F. Chaya1, R. Rodriguez Colon1, D. Boczar1, D. J. Ceradini1, E. D. Rodriguez1, B. E. Gelb2

    1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…
  • 2022 American Transplant Congress

    Correlating Histology, Immunohistochemical, & Serologic Data in Heart Transplant Recipients: Implications for Molecular Diagnostic Assays

    P. Randhawa, Y. Huang

    University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: The ISHLT classification of rejection in heart allograft biopsies is independent of DSA status. There is only limited data on the prevalence of DSA…
  • 2022 American Transplant Congress

    Regulatory Gene Pathways Are Upregulated in Heart Transplant Biopsies with Quilty Lesions

    Q. Cai, L. De Las Casas, J. Torrealba

    Pathology, UTSW Medical Ctr, Dallas, TX

    *Purpose: Quilty lesions (QL) are commonly sub-endocardial lymphoid aggregates found in biopsies from heart transplants. Their appearance and presence in the cardiac tissue is still…
  • 2022 American Transplant Congress

    The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice

    D. R. Butcher, B. D. Thompson, H. K. Singh, V. Nickeleit

    Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC

    *Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…
  • 2022 American Transplant Congress

    Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity

    L. Li1, M. Shirkey1, T. Zhang1, W. Piao1, V. Saxena1, Z. Mei1, Y. Guo1, A. Krupnick1, A. Kensiski1, S. Gavzy1, R. Abdi2, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…
  • 2022 American Transplant Congress

    Circulating and Intragraft Donor (HLA)-Specific B Cells Drive Allograft Rejection After Kidney Transplantation

    A. Torija1, N. Bolaños1, L. Donadeu1, M. Meneghini2, I. Torres2, A. Gabaldon2, M. Gomà3, E. Crespo1, F. Moreso4, O. Bestard2

    1Vall d'Hebron Research Institute (VHIR), Barcelona, Spain, 2Vall d'Hebron University Hospital, Barcelona, Spain, 3Bellvitge University Hospital, Barcelona, Spain, 4Vall d'Heron University Hospital, Barcelona, Spain

    *Purpose: Besides donor-specific antibodies (DSA), circulating donor(HLA)-specific memory B cells (mBc) have also shown to play a deleterious role driving antibody-mediated rejection (ABMR) in kidney…
  • 2022 American Transplant Congress

    Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study

    R. Zahr1, D. Puliyanda2, I. Ashoor3, N. Hayde4, S. Solomon5, R. Engen6, L. Harshman7, C. Peterson8, S. McEwen9, A. Jain10, R. Garro11, A. Mansuri12, M. Kallash13, K. Twombley14

    1Pediatrics, University of Tennessee Health Science Center, Memphis, TN, 2Cedars-Sinai Med Ctr, West Hollywood, CA, 3Pediatrics, Lousiana State University, New Orleans, LA, 4Montefiore Medical Center, Bronx, NY, 5The Children's Hospital at Montefiore, New York, NY, 6Pediatrics, University of Wisconsin Madison, Madison, WI, 7University of Iowa Children's Hospital, Iowa City, IA, 8University of Utah, Salt Lake City, UT, 9University of Minnesota, Minneapolis, MN, 10Pediatrics, Wayne State University, Troy, MI, 11Emory University, Atlanta, GA, 12Pediatrics, Augusta University, Augusta, GA, 13Pediatrics, The Ohio State Univesrity, Columbus, OH, 14Medical University of South Carolina, Charleston, SC

    *Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…
  • 2022 American Transplant Congress

    Pre-Transplant Evaluation of Patients Undergoing Combined Heart-Liver Transplantation and Correlation with Explant Pathology

    A. Shingina1, J. N. Menachem1, S. Brown1, I. A. Ziogas2, W. K. Wu3, M. J. Izzy4, J. Liang1, K. Washington1, S. Alexopoulos5

    1Vanderbilt University Medical Center, Nashville, TN, 2Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, 3Thoracic Surgery; Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, 4GI and Hepatology, Vanderbilt University Medical Center, Nashville, TN, 5Vanderbilt Medical Center, Nashville, TN

    *Purpose: Fontan-associated liver disease (FALD) is a well-described complication of Fontan physiology. More patients with failing Fontan are being evaluated for heart transplant and evidence-based…
  • 2022 American Transplant Congress

    Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation

    B. Rocque1, D. Sarode2, A. Barbetta3, P. Singh4, C. Goldbeck4, C. Weaver5, O. Akbari4, R. Kohli5, J. Emamaullee6

    1University of Southern California Keck School of Medicine, Los Angeles, CA, 2Keck School of Medicine of University of Southern California, Pasadena, CA, 3Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, 4Keck School of Medicine of USC, Los Angeles, CA, 5Childrens Hospital Los Angeles, Los Angeles, CA, 6University of Southern California, Los Angeles, CA

    *Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
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