Articles tagged "Histology"

2018 American Transplant Congress
Nephrosclerosis beyond That Expected for Age is Predictive of Early New-Onset Hypertension (HTN) in Living Kidney Donors (LKD)
N. Issa,¹ L. Vaughan,¹ A. Denic,¹ V. Nagineni,¹ H. Chakkera,² J. Lieske,¹ L. Lerman,¹ S. Taler,¹ M. Stegall,¹ W. Kremers,¹ E. Poggio,³ A. Rule.¹
¹Mayo Clinic, Rochester, MN; ²Mayo Clinic, Scottsdale, AZ; ³Cleveland Clinic, Cleveland, OH.
Background: Nephrosclerosis on biopsy (bx) of LKD is associated with older age & HTN. We studied whether nephrosclerosis is predictive of adverse changes early after…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
J. Friedman,¹ M. Samamrco,¹ L. Marrero,¹ B. Bunnell,¹ D. Spyropoulos.²
¹Tulane University, New Orleans; ²MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…
2018 American Transplant Congress
An Integrative Approach for the Assessment of Peritubular Capillaritis Extent and Score in Microvascular Inflammation – Association with Transplant Glomerulopathy and Graft Loss
N. Kozakowski,¹ H. Herkner,² F. Eskandary,³ M. Eder,³ W. Winnicki,³ G. Bond,³ Ž. Kikić.³
¹Department of Pathology, Medical University of Vienna, Vienna, Austria; ²Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria; ³Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Background:Banff Classification accepts two histomorphological features as surrogates of HLA Antibody-Antigen interaction on renal endothelium: C4d staining and microvascular inflammation scores (MVI sum score:ptc+g≥2) which…
2018 American Transplant Congress
Transplant Tourism and Invasive Fungal Infection
F. Al Ismaili,¹ A. Metry,³ M. Al Riyami,⁵ F. Khamis,⁶ F. Shaheen,⁷ A. Hola,⁴ I. Al Salmi.²
¹The Renal Medicine, The Royal Hospital, Muscat, Oman; ²The Renal Medicine, The Royal Hospital, Muscat, Oman; ³The Renal Medicine, The Royal Hospital, Muscat, Oman; ⁴Histopathology, SQUH, Muscat, Oman; ⁵Infectious Diseases, The Royal Hospital, Muscat, Oman; ⁶SCOT, SCOT, RIyadh, Saudi Arabia; ⁷The Renal Medicine, The Royal Hospital, Muscat, Oman; ⁸The Renal Medicine, The Royal Hospital, Muscat, Oman.
Deceased and live-related Renal transplant (RTX) are widespread approved methods throughout the world. In-addition, commercial-RTX has gained an access at certain places driven by financial…
2018 American Transplant Congress
Diffuse Optical Non-Invasive Organ Risk (DONOR) Indexing Using Diffuse Reflectance Spectroscopy for Pre-Transplant Evaluation
H. Borron,¹ D. Piao,² A. Hawxby,³ H. Wright,³ E. Rubin.⁴
¹College of Medicine, University of Oklahoma, Oklahoma City, OK; ²School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, OK; ³Oklahoma Transplant Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK; ⁴Pathology, University of Oklahoma, Oklahoma City, OK.
Purpose: Due to large transplant waitlists, a rapid, non-invasive method to evaluate organ quality for transplantation is needed. Diffuse optical spectroscopy (DOSi) is an optical…
2018 American Transplant Congress
Renal Allograft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation
L. Gallon,¹ J. Mathew,¹ S. Bontha,² C. Dumur,² P. Dalal,¹ L. Nadimpalli,¹ D. Maluf,² A. Shetty,¹ S. Ildstad,³ J. Leventhal,¹ V. Mas.²
¹Department of Medicine-Nephrology, Northwestern University, Chicago, IL; ²Department of Surgery, University of Virginia, Charlottesville, VA; ³Departments of Surgery, Physiology and Immunology, University of Louisville, Louisville, KY.
Background: Chronic exposure to immunosuppressive agents for organ transplant results in graft nephrotoxicity, infections and malignancies We have established durable immune tolerance in mismatched related…
2018 American Transplant Congress
Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification
S. Fidder,^1,4 G. Furtmüller,¹ B. Simons,² B. Kern,¹ D. Lough,¹ B. Oh,¹ M. Chicco,¹ C. Brayton,³ W. Lee,¹ D. Cooney,¹ R. Redett,¹ G. Brandacher.¹
¹Dept of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore; ²Dept of Urology, JHU SOM, Baltimore; ³Dept of Molecular & Comparative Pathobiology, JHU SOM, Baltimore; ⁴Plastic and Reconstructive Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…
2018 American Transplant Congress
Scoring Transplant Glomerulopathy Using Morphometry: Correlation with Banff Criteria
M. Morales, A. Denic, W. Park, B. Smith, M. Alexander, M. Stegall.
William J.von Liebig Transplant Center, Mayo Clinic, Rochester, MN.
Background: Transplant glomerulopathy (TG) is a prognostic marker for graft survival. Still, scoring TG using the Banff cg-score remains a challenge and no assessments in…
2018 American Transplant Congress
Pre-Existing Allograft Diabetic Nephropathy from Diabetic Donor is Reversible after Kidney Transplantation in Non-Diabetic Recipient
K. Hotta,¹ D. Iwami,¹ H. Harada,² Y. Fukasawa,² H. Okada,¹ H. Higuchi,¹ T. Hirose,² N. Fukuzawa,² N. Shinohara.¹
¹Hokkaido University Hospital, Sapporo, Japan; ²Sapporo City General Hospital, Sapporo, Japan.
【Introduction】The shortage of kidney donor has limited the treatment of patients with end-stage kidney disease. To use diabetic donor with normal renal function is would…

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