ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.

A. Bodzin, Y. Becker, M. Josephson, P. Witkowski, M. Lockwood, L. Potter, B. Kane, L. Lourenco, J. Millis.

Transplant Center, University of Chicago, Chicago, IL.

Meeting: 2016 American Transplant Congress

Abstract number: 281

Keywords: Biopsy, Histology, Kidney, Rejection

Session Information

Date: Monday, June 13, 2016

Session Name: Concurrent Session: Antibody Mediated Rejection in Kidney Transplantation: De Novo DSA

Session Time: 4:30pm-6:00pm

 Presentation Time: 5:30pm-5:42pm

Location: Ballroom B

Related Abstracts
  • Prospective Randomized Controlled Study Evaluating the Impact of an Electronic Feedback System on Medication Adherence in Solid Organ Transplantation.
  • Prospective Randomized Controlled Study Evaluating the Relationship Between Electronic Adherence Data and Tacrolimus Concentration Data.

Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the SIMpill® System is currently being utilized in kidney transplant(KT) recipients in a 3-year study in which allograft rejection is being evaluated.

Methods: KT recipients(n=46) were randomized to 4 groups, 2 Intervention Groups(I1 & I2) or 2 Control Groups(C1 & C2). Subjects enrolled in I1, I2 and C1 received the SIMpill® Electronic Medication Adherence Monitoring System. C2 did not receive a device. This system is a medication-dispensing device that communicates and stores timing of openings, or doses taken to a secure server. The Intervention Group subjects received notification if a scheduled IM dose was missed via text message and/or email. In addition, in I2, if a scheduled dose was missed despite the reminder message, a study provider was notified, enabling intervention. In C1 no one received any feedback, but their adherence is stored on the server for analysis.

Results: At one year, 46 KT recipients were enrolled with an average follow-up of 334 days (median=413.5[range 118-559]). Seven of 9 rejections were ACR where 2 of the 9 were ABMR. Five of 7 ACR biopsies were categorized as Banff grade ≤ 2 while the other 2 were classified as borderline. Five of 9 rejection episodes resulted in hospital admission totaling 34 days. One of the 9 subjects with ACR experienced graft failure and died on post-transplant day 140

Adherence Parameter Intervention Group 1 & 2 N=20  Control Group 1 N=26  p-value
# of Biopsies performed  4  9 p=NS
Biopsy Proven Rejection(% of group) 0(0) 9(19.2) <0.005
LOS for treatment days 0 34 <0.001
Total Doses Taken % 90 84 <0.03
Days with Correct Dosing % 87 74 <0.02

.

Conclusions: Preliminary 1-year results demonstrate that utilization of the SIMpill® with feedback on adherence shows a potential reduction in biopsies performed, and rejection episodes as well possibly reducing hospitalizations and cost related to rejection.

CITATION INFORMATION: Bodzin A, Becker Y, Josephson M, Witkowski P, Lockwood M, Potter L, Kane B, Lourenco L, Millis J. Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Bodzin A, Becker Y, Josephson M, Witkowski P, Lockwood M, Potter L, Kane B, Lourenco L, Millis J. Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/randomized-controlled-study-evaluating-adherence-monitoring-with-electronic-feedback-on-reducing-renal-allograft-rejection/. Accessed February 25, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Home
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.