Articles tagged "Histology"

2016 American Transplant Congress
Everolimus with Low-Dose Tacrolimus vs. a Standard Immunosuppressive Regimen: Renal Histology at 6 Months in De Novo Renal Transplant Patients.
S. Yilmaz,¹ D. Shaffer,² F. Shihab,³ K. McCague,⁴ D. Patel,⁴ Y. Qazi,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Utah, Salt Lake City, UT; ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁵University of Southern California, Los Angeles, CA; ⁶University of California San Francisco, San Francisco, CA.
Morphologic changes in transplant protocol biopsies provide early evidence of renal damage. This study examined the renal histology of de novo patients 6 months post…
2016 American Transplant Congress
Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.
A. Bodzin, Y. Becker, M. Josephson, P. Witkowski, M. Lockwood, L. Potter, B. Kane, L. Lourenco, J. Millis.
Transplant Center, University of Chicago, Chicago, IL.
Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…
2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
A. Haririan,¹ M. Chaudhry,² J. Papadimitriou,² N. Costa,¹ B. Thomas,¹ M. Mavanur,¹ R. Ugarte,¹ C. Cangro,¹ C. Drachenberg.²
¹Dept of Medicine, Unniversity of Maryland, Baltimore, MD; ²Dept of Pathology, University of Maryland, Baltimore, MD.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
2016 American Transplant Congress
Kidney Structural Characteristics as Predictors of Long-Term Kidney Function in Living Kidney Donors.
J. Mathew,¹ A. Denic,¹ M. Alexander,² T. Vrtiska,³ H. Chakkera,⁴ S. Taler,¹ A. Rule.¹
¹Nephrology, Mayo Clinic, Rochester, MN; ²Pathology, Mayo Clinic, Rochester, MN; ³Radiology, Mayo Clinic, Rochester, MN; ⁴Nephrology, Mayo Clinic, Scottsdale, AZ.
PurposeKidney structural characteristics may be predictive of long-term living donor outcomes such as a lower estimated Glomerular Filtration Rate (eGFR).MethodsAs part of the Renal and…
2016 American Transplant Congress
Natural Language Processing Methods Allow Reliable Extraction of Banff Scores and Grades.
K. Reilly,¹ L. Lenert,¹ H. Anwar,² J. Thompson,¹ D. Taber,¹ P. Mauldin,¹ T. Srinivas.¹
¹MUSC, Charleston; ²IBM, NY.
Objective: National Data are sparse with regard to pathology of rejection. Incorporating biopsy pathology grades and lesion scores into analyses requires manual extraction and entry…
2016 American Transplant Congress
Arteriolar Hyalinosis on Renal Transplant Protocol Biopsies Is Not Associated with Tacrolimus Exposure.
S. Yilmaz,¹ D. Shaffer,² Y. Qazi,³ F. Shihab,⁴ K. McCague,⁵ D. Patel,⁵ F. Vincenti.⁶
¹University of Calgary, Calgary, AB, Canada; ²Vanderbilt University, Nashville, TN; ³University of Southern California, Los Angeles, CA; ⁴University of Utah, Salt Lake City, UT; ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ; ⁶University of California San Francisco, San Francisco, CA.
Previous studies have implicated the development of arteriolar hyalinosis (AH) following kidney transplantation to chronic calcineurin inhibitor nephrotoxicity. Here, we examined the association between tacrolimus…
2015 American Transplant Congress
Banff Criteria Are Inadequate to Assess Chronic Renal Allograft Injury 10 Years Post-Transplantation
L. Cornell, W. Park, F. Cosio, M. Stegall.
Mayo Clinic, Rochester, MN.
Background: The Banff criteria have been developed to assess acute and chronic injury in renal allografts. However, the criteria have been based on biopsies for…
2015 American Transplant Congress
Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney
R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.
Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland.
EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
2015 American Transplant Congress
Outcome of Kidney Transplantation from Older Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens
K. Omoto,¹ D. Toki,¹ M. Okumi,¹ T. Shimizu,¹ H. Ishida,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.
OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantations from older living donors has not been studied yet. We reviewed graft outcomes…
2015 American Transplant Congress
Outcome of Kidney Transplantation from Obese Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens
K. Omoto,¹ D. Toki,¹ M. Okumi,¹ T. Shimizu,¹ H. Ishida,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.
BACKGROUND AND OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantation from obese living donors has not been studied. We reviewed graft…