Articles tagged "Histology"

2015 American Transplant Congress
Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization
C. Burghuber,^1,2 J. Kwun,^1,3 F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.^1,3
¹Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…
2015 American Transplant Congress
Post-Transplant Recurrence of Calcium Oxalate Crystals in Primary Hyperoxaluria Type 1 Detected by Surveillance Biopsies: Incidence, Risk Factors, and Effect on Graft Function
L. Cornell, N. Pamidi, R. Mehta, M. Stegall, E. Lorenz, J. Heimbach, D. Milliner.
Mayo Clinic, Rochester, MN.
Background: Primary hyperoxaluria type 1 (PH1) is a rare metabolic defect that results in oxalate over-production by the liver and leads to renal disease due…
2015 American Transplant Congress
Banff Criteria Are Inadequate to Assess Chronic Renal Allograft Injury 10 Years Post-Transplantation
L. Cornell, W. Park, F. Cosio, M. Stegall.
Mayo Clinic, Rochester, MN.
Background: The Banff criteria have been developed to assess acute and chronic injury in renal allografts. However, the criteria have been based on biopsies for…
2015 American Transplant Congress
MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ A. Perkowska Ptasińska,¹ A. Sadowska,¹ M. Nowaczyk,⁵ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.
MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
2015 American Transplant Congress
Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors
L. Fahmy, A. Massie, B. Orandi, S. Bagnasco, J. Alejo, B. Boyarsky, S. Anjum, R. Montgomery, N. Dagher, D. Segev.
Johns Hopkins, Baltimore.
Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in…
2015 American Transplant Congress
Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts
M. Miura,¹ H. Higashiyama,¹ Y. Fukasawa.²
¹Department of Renal Transplant Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; ²Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.
Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…
2015 American Transplant Congress
A Prospective Study of Renal Function and Histological Changes in Renal Transplant Recipients With Acute Clinical and Subclinical Rejection
S. Chen,¹ R. Mehta,¹ P. Sood,¹ P. Randhawa,² N. Shah,¹ C. Wu,¹ A. Tevar,³ S. Hariharan.¹
¹Nephrology, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Transplant Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
Background: To study the impact on renal function and histological changes in patients(pts) with acute clinical rejection(ACR) and subclinical rejection(SCR) from 3 to 12 month(m)…