ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2020 American Transplant Congress

    The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA

    M. Coemans1, A. Senev1, G. Verbeke2, M. Emonds1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium

    *Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
  • 2020 American Transplant Congress

    The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants

    D. Rychkov

    Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA

    *Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…
  • 2020 American Transplant Congress

    Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation

    A. Bentall1, C. Heybeli2, F. G. Cosio1, M. El Ters1, N. Leung1, M. P. Alexander3

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 2Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

    *Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…
  • 2020 American Transplant Congress

    Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, L. Kamal1, A. King1, L. Kang1, M. Levy1, S. Bobba1, D. Massey1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
  • 2020 American Transplant Congress

    Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy

    V. Kung1, M. Haas1, M. Gillespie2, E. Huang2, R. Sandhu2

    1Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
  • 2020 American Transplant Congress

    Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation

    A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall

    Mayo Clinic, Rochester, Rochester, MN

    *Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
  • 2020 American Transplant Congress

    Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?

    C. M. Edwards1, J. T. Langford1, M. Reschke2, J. R. DiRito1, D. Mulligan1, D. Haakinson1, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT

    *Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
  • 2019 American Transplant Congress

    Correlation between Gene Expression and Histology in Transbronchial Lung Transplant Biopsies

    B. Adam, K. Du, S. Rotich, M. Mengel

    University of Alberta, Edmonton, AB, Canada

    *Purpose: Transbronchial lung transplant biopsies (TBBx) are limited by non-specific histologic lesions and suboptimal interobserver reproducibility. Gene expression offers a potentially more precise, objective and…
  • 2019 American Transplant Congress

    Cluster Analysis of Microvascular Inflammation in Indication Biopsies Unveils Distinct Pathological and Immunological Phenotypes with Prognostic Implications

    J. Malheiro1, A. Silva1, S. Santos1, S. Tafulo2, L. Martins1, L. Dias1, A. Castro-Henriques1

    1Centro Hospitalar do Porto, Porto, Portugal, 2IPST_Porto, Porto, Portugal

    *Purpose: We aimed to define distinct pathological and immunological clusters of 80 cases of MVI diagnosed in indication biopsies and evaluate their prognostic implications.*Methods: The…
  • 2019 American Transplant Congress

    Clostridium difficile Infection Mimics Intestinal Acute Cellular Rejection in Pediatric Multivisceral Transplant – A Case Series

    D. A. Cheung1, T. Beduschi2, A. Tekin2, G. Selvaggi2, R. M. Vianna2, J. Garcia1

    1Pediatric Gastroenterology, University of Miami, Miami, FL, 2Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL

    *Purpose: Clostridium difficile infection (CDI) is the most common healthcare-associated infection in the United States. One out of 8 recipients who undergo transplantation with more…
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