Articles tagged "Histology"

2020 American Transplant Congress
The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA
M. Coemans¹, A. Senev¹, G. Verbeke², M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
2020 American Transplant Congress
The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants
D. Rychkov
Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA
*Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…
2020 American Transplant Congress
Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation
A. Bentall¹, C. Heybeli², F. G. Cosio¹, M. El Ters¹, N. Leung¹, M. P. Alexander³
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, ³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…
2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, L. Kamal¹, A. King¹, L. Kang¹, M. Levy¹, S. Bobba¹, D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
2020 American Transplant Congress
Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy
V. Kung¹, M. Haas¹, M. Gillespie², E. Huang², R. Sandhu²
¹Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
2020 American Transplant Congress
Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?
C. M. Edwards¹, J. T. Langford¹, M. Reschke², J. R. DiRito¹, D. Mulligan¹, D. Haakinson¹, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT
*Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
2020 American Transplant Congress
Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection
E. Peyster¹, S. ArabYarmohommadi², A. Janowczyk², M. Sekulic³, C. Cassol⁴, M. Feldman¹, K. Margulies¹, A. Madabhushi²
¹University of Pennsylvania, Philadelphia, PA, ²Case Western Reserve University, Cleveland, OH, ³University Hospitals Cleveland Medical Center, Cleveland, OH, ⁴Ohio State University, Columbus, OH
*Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
2020 American Transplant Congress
Effects of Mandatory 6-Month Waiting Time Policy on Post-Transplant Outcomes and Explant Pathology in Liver Transplant Patients with Hepatocellular Carcinoma
S. Nagai, T. Kitajima, S. Yeddula, R. Salgia, M. Abouljoud, D. Moonka
Henry Ford Hospital, Detroit, MI
*Purpose: In the United States, current allocation policy mandates a 6-month waiting period before exception scores are granted to liver transplant (LT) candidates with hepatocellular…
2020 American Transplant Congress
Recurrent Lupus Post Kidney Transplantation- The Histological and Clinical Characteristics
A. Bentall¹, W. Jiqiu², A. Kattah¹, M. L. Gonzalez Suarez³, F. G. Cosio¹, M. Mai⁴, H. Khamash⁵, M. D. Stegall⁶, H. Amer¹, L. D. Cornell⁷, F. Fervenza¹, M. P. Alexander⁷
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²National Clinical Research Center of Kidney Diseases, Nanjing University, Nanjing, China, ³Department of Nephrology, University of Mississippi Medical Center, Jackson, MS, ⁴Division of Nephrology and Hypertension, Mayo Clinic, Jackonville, FL, ⁵Division of Nephrology and Hypertension, Mayo Clinic, Scottdale, AZ, ⁶Department of Transplant Surgery, Mayo Clinic, Rochester, MN, ⁷Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Lupus nephritis (LN) progresses to ESRD in