ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2021 American Transplant Congress

    Plasma Donor-Derived Cell-Free DNA Levels Risk-Stratify Kidney Allograft Injury with Isolated Transplant Glomerulitis

    L. Bu1, S. Anand2, A. Pai3, J. S. Bromberg4, G. Gupta5, I. Moinuddin5, T. Alhamad6, V. Bowers7, S. Ghosh8, W. Tian8, E. Stites9

    1University of Minnesota, Minneapolis, MN, 2Intermountain Medical Center, Murray, UT, 3University of Texas McGovern Medical School, Houston, TX, 4University of Maryland School of Medicine, Baltimore, MD, 5Virginia Commonwealth University, Richmond, VA, 6Washington University in St. Louis, St. Louis, MO, 7Tampa General Hospital, Tampa, FL, 8CareDx, Brisbane, CA, 9University of Colorado, Aurora, CO

    *Purpose: The Banff lesion Glomerulitis (g) characterizes the degree of microvascular glomerular inflammation. Some studies have demonstrated glomerulitis in the absence of C4d in association…
  • 2021 American Transplant Congress

    Treatment of Refractory Chronic Active Antibody-Mediated Rejection: Improvement in Histopathology are Delayed Compared to the Reduction in Donor Specific Antibodies

    K. R. Degner1, S. Parajuli1, F. Aziz1, N. Garg1, M. Mohamed1, D. A. Mandelbrot1, S. E. Panzer1, L. Hidalgo1, N. A. Wilson1, S. R. Reese1, K. Van Hyfte1, W. Zhong1, P. Nickerson2, A. Djamali1

    1University of Wisconsin, Madison, WI, 2University of Manitoba, Winnipeg, MB, Canada

    *Purpose: There are limited options for the treatment and management of refractory chronic active antibody-mediated rejection (cABMR) after kidney transplantation. Longitudinal histologic data in patients…
  • 2021 American Transplant Congress

    Association of Donor-Derived Cell-Free DNA with Severity of Interstitial Fibrosis and Cortical Atrophy Lesions Following Kidney Transplantation

    L. Bu1, E. Stites2, V. Bowers3, T. Alhamad4, J. S. Bromberg5, G. Gupta6, I. Moinuddin6, S. Ghosh7, W. Tian7, A. Pai8, S. Anand9

    1University of Minnesota, Minneapolis, MN, 2University of Colorado, Aurora, CO, 3Tampa General Hospital, Tampa, FL, 4Washington University in St. Louis, St. Louis, MO, 5University of Maryland School of Medicine, Baltimore, MD, 6Virginia Commonwealth University, Richmond, VA, 7CareDx, Brisbane, CA, 8University of Texas McGovern Medical School, Houston, TX, 9Intermountain Medical Center, Murray, UT

    *Purpose: The most common cause of kidney transplant (KT) failure is the poorly characterized histopathologic entity “interstitial fibrosis and tubular atrophy” (IFTA). There are no…
  • 2021 American Transplant Congress

    Perivenular Fibrosis After Pediatric Liver Transplant

    J. Lew, S. Cho, S. Feng, E. R. Perito

    UCSF, San Francisco, CA

    *Purpose: Graft fibrosis is a concerning long-term complication after pediatric liver transplant (LT) and though perivenular (PV) fibrosis is common, its likelihood of progression and…
  • 2020 American Transplant Congress

    Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, L. Kamal1, A. King1, L. Kang1, M. Levy1, S. Bobba1, D. Massey1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
  • 2020 American Transplant Congress

    Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy

    V. Kung1, M. Haas1, M. Gillespie2, E. Huang2, R. Sandhu2

    1Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
  • 2020 American Transplant Congress

    Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation

    A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall

    Mayo Clinic, Rochester, Rochester, MN

    *Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
  • 2020 American Transplant Congress

    Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?

    C. M. Edwards1, J. T. Langford1, M. Reschke2, J. R. DiRito1, D. Mulligan1, D. Haakinson1, G. T. Tietjen1

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT

    *Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
  • 2020 American Transplant Congress

    Computer-Assisted Cardiac Histologic Evaluation (CACHE) for Grading Cardiac Allograft Rejection

    E. Peyster1, S. ArabYarmohommadi2, A. Janowczyk2, M. Sekulic3, C. Cassol4, M. Feldman1, K. Margulies1, A. Madabhushi2

    1University of Pennsylvania, Philadelphia, PA, 2Case Western Reserve University, Cleveland, OH, 3University Hospitals Cleveland Medical Center, Cleveland, OH, 4Ohio State University, Columbus, OH

    *Purpose: Cardiac allograft rejection (CAR) is a serious concern in heart transplantation, occurring in 30-40% of patients during the first year. Endomyocardial biopsy (EMB) with…
  • 2020 American Transplant Congress

    Effects of Mandatory 6-Month Waiting Time Policy on Post-Transplant Outcomes and Explant Pathology in Liver Transplant Patients with Hepatocellular Carcinoma

    S. Nagai, T. Kitajima, S. Yeddula, R. Salgia, M. Abouljoud, D. Moonka

    Henry Ford Hospital, Detroit, MI

    *Purpose: In the United States, current allocation policy mandates a 6-month waiting period before exception scores are granted to liver transplant (LT) candidates with hepatocellular…
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