Articles tagged "Histology"

2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
U. S. Udoh¹, J. D. Sanabria¹, M. Banerjee¹, P. K. Rajan¹, M. Schade¹, J. A. Sanabria¹, A. Mallick¹, G. Smith¹, G. U. Udoh², K. Sodhi¹, S. Pierre², Z. Xie², J. Shapiro², J. Sanabria¹
¹Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, ²Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
2021 American Transplant Congress
Sampling Renal Biopsies in Pre-Clinical Research for Comprehensive Assessment
C. M. Edwards¹, C. Albert², D. Stern¹, J. Langford¹, W. Day², J. R. DiRito¹, W. M. Saltzman², M. Kashgarian³, J. S. Pober⁴, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale School of Medicine, New Haven, CT, ³Pathology, Yale School of Medicine, New Haven, CT, ⁴Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Previous literature has demonstrated that single biopsies are not representative of a whole kidney in clinical assessments. In this study we aimed to design…
2021 American Transplant Congress
Impact of Treatment of Subclinical Rejection at 2 Weeks After Kidney Transplantation, Compared by 1 Year Histologic Outcomes
O. Lee¹, K. Lee¹, J. Park¹, J. Lee², G. Kwon³, K. Kim⁴
¹Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Pathology, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Biostatistics, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Subclinical rejection (SCR) is associated with chronic allograft nephropathy, which is the most common cause of allograft failure in kidney transplantation (KT). Therefore, early…
2021 American Transplant Congress
Plasma Donor-Derived Cell-Free DNA Levels Risk-Stratify Kidney Allograft Injury with Isolated Transplant Glomerulitis
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, G. Gupta⁵, I. Moinuddin⁵, T. Alhamad⁶, V. Bowers⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Virginia Commonwealth University, Richmond, VA, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Tampa General Hospital, Tampa, FL, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: The Banff lesion Glomerulitis (g) characterizes the degree of microvascular glomerular inflammation. Some studies have demonstrated glomerulitis in the absence of C4d in association…
2020 American Transplant Congress
Recurrent Diabetic Nephropathy Post Kidney Transplant is Associated with High Risk of Mortality
A. Kukla, M. Merzkani, W. Park, B. Smith, S. Turkevi-Nagy, P. Zhang, X. Benavides, M. Morales Alvarez, A. Denic, A. Bentall, Y. Kudva, M. D'Costa, P. Alexander, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: The goal of the study was to determine the incidence of recurrent diabetic kidney disease (DKD) after kidney transplantation (KT) and assess its correlation…
2020 American Transplant Congress
Significance of Pathology in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results of the Paramour “Pediatric Renal AMR Outcomes” Study
I. Ashoor¹, A. Jain², R. Garro³, M. Kallash⁴, S. Soloman⁵, K. Twombley⁶
¹LSUHSC and Children's Hospital New Orleans, New Orleans, LA, ²Children's Hospital of Michigan, Detroit, MI, ³Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, ⁴Nationwide Children's Hospital, Columbus, OH, ⁵Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, ⁶Medical University of South Carolina, Charleston, SC
*Purpose: Little is known about how pathology findings on biopsy correlate with outcomes in pediatric kidney transplant patients with antibody mediated rejection (AMR). We aimed…
2020 American Transplant Congress
Efficacy of Radiofrequency Ablation in the Treatment of Patients with Hepatocellular Carcinoma and Compensated Liver Disease: A Pathological Evaluation of Liver Explants
W. Alhamoudi¹, I. Salih², S. Yousif², M. Shawkat³, K. Bzeizi², A. Albenmousa², S. Alghamdi², M. Sturdevant², D. Broering², H. Alsuhaibani²
¹Medicine, King Saud University, Riyadh, Saudi Arabia, ²Liver Transplant, King Faisal Specialist Hospital, Riyadh, Saudi Arabia, ³Internal Medicine, Minia University, Minia, Egypt
*Purpose: Radiofrequency ablation (RFA) is a safe and effective treatment for patients with limited hepatocellular carcinoma (HCC). Ablative outcomes have been largely based on radiological…
2020 American Transplant Congress
The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA
M. Coemans¹, A. Senev¹, G. Verbeke², M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
2020 American Transplant Congress
The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants
D. Rychkov
Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA
*Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…
2020 American Transplant Congress
Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation
A. Bentall¹, C. Heybeli², F. G. Cosio¹, M. El Ters¹, N. Leung¹, M. P. Alexander³
¹Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ²Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, ³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…