ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2021 American Transplant Congress

    Impact of Treatment of Subclinical Rejection at 2 Weeks After Kidney Transplantation, Compared by 1 Year Histologic Outcomes

    O. Lee1, K. Lee1, J. Park1, J. Lee2, G. Kwon3, K. Kim4

    1Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Medicine, Samsung Medical Center, Seoul, Korea, Republic of, 3Pathology, Samsung Medical Center, Seoul, Korea, Republic of, 4Biostatistics, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Subclinical rejection (SCR) is associated with chronic allograft nephropathy, which is the most common cause of allograft failure in kidney transplantation (KT). Therefore, early…
  • 2021 American Transplant Congress

    Plasma Donor-Derived Cell-Free DNA Levels Risk-Stratify Kidney Allograft Injury with Isolated Transplant Glomerulitis

    L. Bu1, S. Anand2, A. Pai3, J. S. Bromberg4, G. Gupta5, I. Moinuddin5, T. Alhamad6, V. Bowers7, S. Ghosh8, W. Tian8, E. Stites9

    1University of Minnesota, Minneapolis, MN, 2Intermountain Medical Center, Murray, UT, 3University of Texas McGovern Medical School, Houston, TX, 4University of Maryland School of Medicine, Baltimore, MD, 5Virginia Commonwealth University, Richmond, VA, 6Washington University in St. Louis, St. Louis, MO, 7Tampa General Hospital, Tampa, FL, 8CareDx, Brisbane, CA, 9University of Colorado, Aurora, CO

    *Purpose: The Banff lesion Glomerulitis (g) characterizes the degree of microvascular glomerular inflammation. Some studies have demonstrated glomerulitis in the absence of C4d in association…
  • 2021 American Transplant Congress

    Treatment of Refractory Chronic Active Antibody-Mediated Rejection: Improvement in Histopathology are Delayed Compared to the Reduction in Donor Specific Antibodies

    K. R. Degner1, S. Parajuli1, F. Aziz1, N. Garg1, M. Mohamed1, D. A. Mandelbrot1, S. E. Panzer1, L. Hidalgo1, N. A. Wilson1, S. R. Reese1, K. Van Hyfte1, W. Zhong1, P. Nickerson2, A. Djamali1

    1University of Wisconsin, Madison, WI, 2University of Manitoba, Winnipeg, MB, Canada

    *Purpose: There are limited options for the treatment and management of refractory chronic active antibody-mediated rejection (cABMR) after kidney transplantation. Longitudinal histologic data in patients…
  • 2021 American Transplant Congress

    Association of Donor-Derived Cell-Free DNA with Severity of Interstitial Fibrosis and Cortical Atrophy Lesions Following Kidney Transplantation

    L. Bu1, E. Stites2, V. Bowers3, T. Alhamad4, J. S. Bromberg5, G. Gupta6, I. Moinuddin6, S. Ghosh7, W. Tian7, A. Pai8, S. Anand9

    1University of Minnesota, Minneapolis, MN, 2University of Colorado, Aurora, CO, 3Tampa General Hospital, Tampa, FL, 4Washington University in St. Louis, St. Louis, MO, 5University of Maryland School of Medicine, Baltimore, MD, 6Virginia Commonwealth University, Richmond, VA, 7CareDx, Brisbane, CA, 8University of Texas McGovern Medical School, Houston, TX, 9Intermountain Medical Center, Murray, UT

    *Purpose: The most common cause of kidney transplant (KT) failure is the poorly characterized histopathologic entity “interstitial fibrosis and tubular atrophy” (IFTA). There are no…
  • 2020 American Transplant Congress

    Efficacy of Radiofrequency Ablation in the Treatment of Patients with Hepatocellular Carcinoma and Compensated Liver Disease: A Pathological Evaluation of Liver Explants

    W. Alhamoudi1, I. Salih2, S. Yousif2, M. Shawkat3, K. Bzeizi2, A. Albenmousa2, S. Alghamdi2, M. Sturdevant2, D. Broering2, H. Alsuhaibani2

    1Medicine, King Saud University, Riyadh, Saudi Arabia, 2Liver Transplant, King Faisal Specialist Hospital, Riyadh, Saudi Arabia, 3Internal Medicine, Minia University, Minia, Egypt

    *Purpose: Radiofrequency ablation (RFA) is a safe and effective treatment for patients with limited hepatocellular carcinoma (HCC). Ablative outcomes have been largely based on radiological…
  • 2020 American Transplant Congress

    The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA

    M. Coemans1, A. Senev1, G. Verbeke2, M. Emonds1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), KU Leuven, Leuven, Belgium

    *Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…
  • 2020 American Transplant Congress

    The Composite Molecular and Cellular Instability Score Identifies the Sub-Phenotypes of Histologically Stable Kidney Transplants

    D. Rychkov

    Department of Surgery, BCHSI, University of California San Francisco, San Francisco, CA

    *Purpose: Recent molecular studies have highlighted the unrecognized burden of sub-clinical graft rejection of a histologically stable allograft, defined as transplants with absence of clinical…
  • 2020 American Transplant Congress

    Risk of Histological Relapse in Patients with Monoclonal Gammopathy of Renal Significance after Kidney Transplantation

    A. Bentall1, C. Heybeli2, F. G. Cosio1, M. El Ters1, N. Leung1, M. P. Alexander3

    1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, 2Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

    *Purpose: There is increased recognition of Monoclonal Gammopathy of Renal Significance (MGRS) but data on kidney transplant (ktx)outcomes are lacking. We assessed KTX outcomes of…
  • 2020 American Transplant Congress

    Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, L. Kamal1, A. King1, L. Kang1, M. Levy1, S. Bobba1, D. Massey1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
  • 2020 American Transplant Congress

    Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy

    V. Kung1, M. Haas1, M. Gillespie2, E. Huang2, R. Sandhu2

    1Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
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