Articles tagged "Histology"

2022 American Transplant Congress
Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation
K. Lee, J. Park
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…
2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
M. R. Weir¹, D. Mandelbrot², J. S. Bromberg¹, S. Mehta³, E. Poggio⁴, E. Huang⁵, G. Shekhtman⁶, N. Agrawal⁷, W. Tian⁸, M. Cooper⁹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Wisconsin, Madison, WI, ³University of Alabama, Birmingham, AL, ⁴Cleveland Clinic, Cleveland, OH, ⁵Cedars-Sinai Medical Center, Los Angeles, CA, ⁶CareDx Inc., Brisbane, CA, ⁷CareDx Inc, Brisbane, CA, ⁸CareDx, Brisbane, CA, ⁹MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
M. J. Ellis¹, T. Maw², E. Huang³, E. Stites⁴, F. Shihab⁵, D. C. Brennan⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, S. Kung⁸
¹Duke University, Durham, NC, ²University of Southern California, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Colorado, Aurora, CO, ⁵University of Utah, Salt Lake City, UT, ⁶Johns Hopkins School of Medicine, Baltimore, MD, ⁷CareDx, Brisbane, CA, ⁸University of California, San Francisco, San Francisco, CA
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
2022 American Transplant Congress
A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques
R. S. Bermea¹, K. Ingersoll², L. P. Hariri³, M. Warren², L. Kean², V. Tkachev²
¹Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, MA, ²Hematology/Oncology, Boston Children's Hospital, Boston, MA, ³Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…
2022 American Transplant Congress
Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)
S. R. Allam¹, M. Cooper², D. Kumar³, T. Maw⁴, A. Wiseman⁵, P. Chuang⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, E. Huang⁸
¹Medical City Transplant Institute, Fort Worth, TX, ²Medstar Georgetown Transplant Institute, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴University of Southern California, Los Angeles, CA, ⁵Centura Health, Denver, CO, ⁶Metrolina Nephrology, Charlotte, NC, ⁷CareDx, Brisbane, CA, ⁸Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Associations between non-rejection histologic diagnoses and dd-cfDNA have not been extensively characterized. We explored these associations in kidney transplant recipients enrolled in the Kidney…
2021 American Transplant Congress
The Pathology of Heart Allograft Biopsies: Discrepancies in Interpretation Between Conventional Histology and the Molecular Microscope Diagnostic (MMDx®) System
P. Randhawa¹, A. Seitz², Y. Huang¹, B. Feingold²
¹Department of Pathology, Pittsburgh, PA, ²Pediatrics, University of Pittsburgh, Pittsburgh, PA
*Purpose: There is growing interest in using transcriptomics to complement histologic evaluation of allograft hearts. The present study scrutinizes discrepancies between histologic and MMDx® systems…
2021 American Transplant Congress
Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, T. Alhamad⁵, V. Bowers⁶, I. Moinuddin⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹, G. Gupta⁷
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷Virginia Commonwealth University, Richmond, VA, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
U. S. Udoh¹, J. D. Sanabria¹, M. Banerjee¹, P. K. Rajan¹, M. Schade¹, J. A. Sanabria¹, A. Mallick¹, G. Smith¹, G. U. Udoh², K. Sodhi¹, S. Pierre², Z. Xie², J. Shapiro², J. Sanabria¹
¹Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, ²Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
2021 American Transplant Congress
Sampling Renal Biopsies in Pre-Clinical Research for Comprehensive Assessment
C. M. Edwards¹, C. Albert², D. Stern¹, J. Langford¹, W. Day², J. R. DiRito¹, W. M. Saltzman², M. Kashgarian³, J. S. Pober⁴, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale School of Medicine, New Haven, CT, ³Pathology, Yale School of Medicine, New Haven, CT, ⁴Immunobiology, Yale School of Medicine, New Haven, CT
*Purpose: Previous literature has demonstrated that single biopsies are not representative of a whole kidney in clinical assessments. In this study we aimed to design…
2021 American Transplant Congress
Impact of Treatment of Subclinical Rejection at 2 Weeks After Kidney Transplantation, Compared by 1 Year Histologic Outcomes
O. Lee¹, K. Lee¹, J. Park¹, J. Lee², G. Kwon³, K. Kim⁴
¹Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Medicine, Samsung Medical Center, Seoul, Korea, Republic of, ³Pathology, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Biostatistics, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Subclinical rejection (SCR) is associated with chronic allograft nephropathy, which is the most common cause of allograft failure in kidney transplantation (KT). Therefore, early…