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American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2015 American Transplant Congress

    Treatment of Subclinical Rejection Identified On Surveillance Biopsy May Prevent the Development of Chronic Alloimmune Injury

    M. Willicombe, C. Roufosse, J. Galliford, A. McLean, D. Taube.

    Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom.

    Surveillance biopsies [SBx] are not universally performed following renal transplantation. In patients in whom protocol biopsies are performed, how best to manage subclinical rejection [SCR]…
  • 2015 American Transplant Congress

    Post-Transplant Recurrence of Calcium Oxalate Crystals in Primary Hyperoxaluria Type 1 Detected by Surveillance Biopsies: Incidence, Risk Factors, and Effect on Graft Function

    L. Cornell, N. Pamidi, R. Mehta, M. Stegall, E. Lorenz, J. Heimbach, D. Milliner.

    Mayo Clinic, Rochester, MN.

    Background: Primary hyperoxaluria type 1 (PH1) is a rare metabolic defect that results in oxalate over-production by the liver and leads to renal disease due…
  • 2015 American Transplant Congress

    A New Diagnostic and Pronostic Tool for Antibody Mediated Rejection in Kidney Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 S. Caillard,1 N. Froelich,2 L. Marcellin,3 C. Muller,1 G. Gautier-Vargas,1 P. Perrin,1 L. Braun-Parvez,1 F. Heibel,1 C. Gachet,2 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the main cause of loss of the kidney transplant. Despite the new BANFF classification, diagnostic difficulties and…
  • 2015 American Transplant Congress

    MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy

    J. Pazik,1 M. Oldak,2 Z. Lewandowski,3 D. Ozieblo,4 K. Michalska,5 A. Perkowska Ptasińska,1 A. Sadowska,1 M. Nowaczyk,5 J. Malejczyk,4 M. Durlik.1

    1Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; 2Institute of Physiology and Pathology of Hearing, Warsaw, Poland; 3Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; 4Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; 5Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.

    MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
  • 2015 American Transplant Congress

    Banff Criteria Are Inadequate to Assess Chronic Renal Allograft Injury 10 Years Post-Transplantation

    L. Cornell, W. Park, F. Cosio, M. Stegall.

    Mayo Clinic, Rochester, MN.

    Background: The Banff criteria have been developed to assess acute and chronic injury in renal allografts. However, the criteria have been based on biopsies for…
  • 2015 American Transplant Congress

    Morphometry of the Epithelial-Mesenchymal Transition (EMT) in Subsequent Biopsies from Transplanted Kidney

    R. Świder, A. Perkowska-Ptasińska, A. Stachurska, J. Fabijańska-Mitek, R. Zagożdżon, S. Gruca, J. Gołąb, M. Durlik.

    Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immudohaematology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Immunology, Medical University, Warsaw, Poland; Department of Transplantation Medicine, Medical University, Warsaw, Poland.

    EMT plays the principal role in the pathogenesis of IF/TA as a consequence in the failure of a transplanted kidney. Many facts suggest that the…
  • 2015 American Transplant Congress

    Outcome of Kidney Transplantation from Older Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens

    K. Omoto,1 D. Toki,1 M. Okumi,1 T. Shimizu,1 H. Ishida,1 K. Honda,2 J. Koike,3 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.

    OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantations from older living donors has not been studied yet. We reviewed graft outcomes…
  • 2015 American Transplant Congress

    Outcome of Kidney Transplantation from Obese Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens

    K. Omoto,1 D. Toki,1 M. Okumi,1 T. Shimizu,1 H. Ishida,1 K. Honda,2 J. Koike,3 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.

    BACKGROUND AND OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantation from obese living donors has not been studied. We reviewed graft…
  • 2015 American Transplant Congress

    Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM

    S. Panzer,1 S. Reese,1 N. Wilson Schlei,1 W. Zhong,2 A. Djamali.1

    1Medicine, University of Wisconsin Madison, Madison, WI; 2Pathology, University of Wisconsin Madison, Madison, WI.

    PurposeChronic active antibody mediated rejection (cAMR) and transplant glomerulopathy (TG) are major determinants of long-term allograft survival. However, the contribution of DSA and glomerular immunoglobulins…
  • 2015 American Transplant Congress

    Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization

    C. Burghuber,1,2 J. Kwun,1,3 F. Leopardi,3 A. Gibby,1 A. Farris,1 N. Iwakoshi,1 S. Knechtle.1,3

    1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria; 3Duke University, Durham, NC.

    [Background] Preformed and newly formed alloantibody post transplantation (TX) can significantly deteriorate graft survival. Patterns of humoral rejection in sensitized patients varies significantly due to…
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