Session Time: 4:00pm-5:30pm
Presentation Time: 5:12pm-5:24pm
Location: Terrace IV
Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in live donors remains unknown.
METHODS: We abstracted % glomerulosclerosis (GS) and extent of interstitial fibrosis (IF) from T0-RBx of 220 live donors at our center and linked to donor estimated glomerular filtration rate (eGFR) obtained from post-donation medical records with median 7.2 years of followup time. We used multilevel mixed-effects linear regression to model the association between biopsy results and eGFR trajectory over time.
RESULTS: Median (IQR) GS was 4.8% (0%-9.7%). Minimal IF was observed in 72.5% and mild/moderate IF was observed in 27.6% of biopsies. In an age-unadjusted model with GS and IF, a 10% increase in GS was associated with eGFR decrease of 0.33 2.28 4.22 (p=0.02, Table 1). Mild/moderate IF (vs minimal) was associated with decreased eGFR (-7.48 -3.80 -0.13, p=0.03), but there was no evidence of association after adjustment for GS (-5.78 -1.82 2.14, p=0.4) (Table 1). Both GS and IF were statistically insignificant after adjusting for age (Table 1). Interaction terms were also statistically insignificant.
CONCLUSION: Mild GS in live donors was associated with decreased short-term post-donation eGFR; however this association disappeared after adjusting for age.
|Model 1||Model 2||Model 3||Model 4|
|Per year (0-10y)||0.670.961.25**||0.650.941.23**||0.670.961.25**||0.620.901.18**|
|Per year (>10y)||-1.98-0.690.60||-1.98-0.690.60||-2.01-0.730.56||-2.06-0.780.51|
|GS (per 10%)||-4.42-2.64-0.86**||-4.22-2.28-0.33||-2.62-0.850.91|
|Mild/Moderate IF (vs Minimal)||-7.48-3.80-0.13||-5.78-1.822.14||-4.53-1.002.53|
|Age (per 10y)||-6.88-5.45-4.02**|
To cite this abstract in AMA style:Fahmy L, Massie A, Orandi B, Bagnasco S, Alejo J, Boyarsky B, Anjum S, Montgomery R, Dagher N, Segev D. Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/association-between-histological-abnormalities-in-time-zero-renal-biopsies-and-post-donation-egfr-in-live-donors/. Accessed September 16, 2019.
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