2018 American Transplant Congress
A New Reality: Virtual Crossmatch Can Be Used Successfully as Pre-Transplant Compatibility Testing for Most Deceased Donor Transplants at a High Volume Center
Aim: We developed a reliable virtual crossmatch (VXM) method for use as pre-transplant XM for deceased donor (DD) kidney transplantation (KTx). Here we report the…2018 American Transplant Congress
Acute Antibody Mediated Rejection Treatment Impact on Class I and Class II Anti-HLA Antibodies in Pediatric Kidney Transplant Recipients
Purpose: Characterize class I and class II donor specific antibodies (DSA) response to acute antibody mediated rejection (AMR) treatment in pediatric kidney transplant recipients (KTR).Methods:…2018 American Transplant Congress
Flow DSA-XM: Better Crossmatch or Just Different Problems?
Surgery, VCUHealth Systems, Richmond, VA.
Background. Despite the positive impact of flow crossmatching(FCXM) upon alloantibody detection, its inability to distinguish anti-Class I from Class II or non-HLA from HLA-antibodies remain…2018 American Transplant Congress
Shortened Cold Ischemia Time and Reduced Incidence of Delayed Graft Function for Kidney Transplants through Enhanced Tissue Compatibility Testing
A. HLA-typing and prospective leukocyte cross-matching needed for deceased donor kidney transplantation (kTX) may delay the onset of surgery. We compared cold ischemia times (CIT)…2017 American Transplant Congress
Using Buccal Swabs for Deceased Organ Donor HLA Typing.
Aim: In some cases, getting enough cells from a deceased donor to perform crossmatches and DNA extraction for HLA typing is challenging. Specifically this is…2017 American Transplant Congress
Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.
Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…2017 American Transplant Congress
Harnessing Scientific and Technological Advances to Improve Equity in Kidney Allocation Policies.
To increase the likelihood of finding a compatible donor, kidney allocation systems prioritize highly sensitized patients to counterbalance the impact of HLA allo-sensitization and preclude…2017 American Transplant Congress
MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: Regulatory T cell (Tregs) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Although Treg suppression requires initial activation through cell…2017 American Transplant Congress
Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.
Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…2017 American Transplant Congress
A Novel Computational HLA Matching Algorithm for Improving Donor-Recipient Histocompatibility and Graft Outcomes After Kidney Transplantation.
Introduction: Human Leukocyte Antigen (HLA) matching is a central objective of kidney allocation policies, but current assessment of histocompatibility is inadequate. Building on our previous…
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