ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility"

  • 2018 American Transplant Congress

    Can We Expect the “Unexpected”?

    D. Pinelli, A. Tambur.

    Northwestern University, Chicago.

    A known, seemingly paradoxical, phenomenon of the HLA system is the high overall degree of homology among different HLA alleles, despite vast polymorphism in the…
  • 2018 American Transplant Congress

    Temporal Variability of IgG Subclasses

    D. Pinelli, M. Gopalakrishnan, A. Joong, P. Thrush, A. Tambur.

    Northwestern University, Chicago; Lurie Children's Hospital, Chicago.

    The temporal model of IgG subclass switching supports sequential IgG conversion; however, the diversity of previously stimulated B cells is known to shape responses in…
  • 2018 American Transplant Congress

    Delayed Graft Function in Live Donor HLA-Incompatible Kidney Transplant Recipients: A Multicenter Study

    J. Motter,1 A. Massie,1 J. Garonzik Wang,1 K. Jackson,1 X. Luo,1 A. Muzaale,1 B. Orandi,2 D. Segev.1

    1JHU, Baltimore; 2UCSF, San Francisco.

    Background: Many patients with a willing, but incompatible live donor choose to undergo incompatible live donor kidney transplantation (ILDKT) facilitated by desensitization procedures to eliminate…
  • 2018 American Transplant Congress

    A Novel Endothelial Cell Based Complement Dependent Cytotoxicity Test in Kidney Transplantation

    R. Lammerts,1 J. van den Born,1 W. Dam,1 M. Seelen,1 B. Hepkema,2 B. Kroesen,2 M. Daha,1 R. Pol,3 S. Berger,1 On behalf of the COMBAT Consortium.1

    1Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands; 2Department of Immunology, University Medical Centre Groningen, Groningen, Netherlands; 3Department of Surgery, University Medical Centre Groningen, Groningen, Netherlands.

    Introduction:Relevant alloantibodies in kidney transplantation comprise anti-HLA antibodies, blood group antibodies (ABO incompatible) and anti-endothelial cell antibodies (AECA) and can initiate antibody-mediated rejection (ABMR). ABMR…
  • 2017 American Transplant Congress

    Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.

    R. Leishman,1 M. Aeder,2 M. Leffell,3 C. Murphey,4 N. Reinsmoen,5 S. Saidman,6 T. Sandholm,7 A. Toll,1 A. Harper,1 N. Turgeon.8

    1UNOS, Richmond, VA; 2Univ Hosp Med Ctr, Cleveland, OH; 3Johns Hopkins Univ, Baltimore, MD; 4SW Immunodiagnostics, San Antonio, TX; 5Cedars-Sinai Health, Los Angeles, CA; 6Mass Gen Hosp, Boston, MA; 7Carnegie Mellon Univ, Pittsburgh, PA; 8Emory Univ, Atlanta, GA

    Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…
  • 2017 American Transplant Congress

    A Novel Computational HLA Matching Algorithm for Improving Donor-Recipient Histocompatibility and Graft Outcomes After Kidney Transplantation.

    V. Kosmoliaptsis,1 D. Mallon,1 S. Fuggle,2 R. Johnson,2 C. Watson,1 J. Bradley,1 C. Taylor.1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom; 2NHS Blood and Transplant, Bristol, United Kingdom

    Introduction: Human Leukocyte Antigen (HLA) matching is a central objective of kidney allocation policies, but current assessment of histocompatibility is inadequate. Building on our previous…
  • 2017 American Transplant Congress

    HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.

    Z. Du, J. Patel, C. Braun, B. Norton.

    Pathology, Loyola University Medical Center, Maywood, IL

    Aim: HLA-DP antibodies can elicit positive crossmatches and be detrimental in organ transplantation. Although HLA-DP unacceptable antigens can be input in the UNOS database, they…
  • 2017 American Transplant Congress

    Eliminating False Positive Virtual Crossmatch Results for Lung Transplant Candidates by Using Multiple Antibody Testing Platforms.

    O. Timofeeva,1 M. Kashem,2 S. Geier,1 D. Grogan,2 S. Keshavamurthy,2 J. Gomez-Abraham,2 Y. Toyoda,2 F. Cordova.2

    1Department of Pathology and Laboratory of Medicine, Temple University, Lewis Katz School of Medicine, Philadelphia, PA; 2Department of Cardiovascular Surgery, Temple University, Lewis Katz School of Medicine, Philadelphia, PA

    Purpose: At present, immunologic risk for lung transplant patients is evaluated based on Virtual crossmatch (VXM) by comparing recipient's HLA antibodies detected by Single antigen…
  • 2017 American Transplant Congress

    Positive Flow Crossmatch After Negative Virtual Crossmatch -A Single Center Experience.

    Q. Xu, S. Leckie.

    Pathology and Lab Medicine, London Health Sciences Center, London, ON, Canada

    Aims: To determine causes of Flow Cytometry crossmatch (FCXM) after a negative virtual crossmatch (VirXM), even with sensitive solid-phase antibody assay and complete HLA typings…
  • 2017 American Transplant Congress

    Using Buccal Swabs for Deceased Organ Donor HLA Typing.

    C. Muse,2 S. Longobardi,1 I. Gimferrer,1 J. Orlowski.2

    1HLA Laboratory, OU Medical Center, Oklahoma City, OK; 2LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    Aim: In some cases, getting enough cells from a deceased donor to perform crossmatches and DNA extraction for HLA typing is challenging. Specifically this is…
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