2018 American Transplant Congress
Flow DSA-XM: Better Crossmatch or Just Different Problems?
Surgery, VCUHealth Systems, Richmond, VA.
Background. Despite the positive impact of flow crossmatching(FCXM) upon alloantibody detection, its inability to distinguish anti-Class I from Class II or non-HLA from HLA-antibodies remain…2018 American Transplant Congress
Shortened Cold Ischemia Time and Reduced Incidence of Delayed Graft Function for Kidney Transplants through Enhanced Tissue Compatibility Testing
A. HLA-typing and prospective leukocyte cross-matching needed for deceased donor kidney transplantation (kTX) may delay the onset of surgery. We compared cold ischemia times (CIT)…2018 American Transplant Congress
Selection and Stratification of Anti-HLA-A and HLA-B Sensitized Patients in Pig-to-Human Xenotransplantation
Introduction: Patients with anti-HLA-A and –B antibodies are difficult to match and represent a possible population for inclusion in pig-to-human xenotransplantation clinical trials. Donor specific…2018 American Transplant Congress
Increasing the Donor Pool for Highly Sensitized Patients with Allele Specific Antibodies: Optimizing the Virtual Crossmatch (vXM)
Background:Since implementation of the current Kidney Allocation System, highly sensitized patients with 98-100% cPRA (HSPs) are receiving ~10% of deceased donor kidneys compared to <2%…2017 American Transplant Congress
Accelerated Rejection of Secondary Third Party Allografts in Older Recipients Is Facilitated by an Augmented Innate Immune Response.
Accumulating evidence acknowledges the central relevance of aging and chronic antigen exposure in shaping the balance of innate and adaptive immunity. Here, we assessed whether…2017 American Transplant Congress
Harnessing Scientific and Technological Advances to Improve Equity in Kidney Allocation Policies.
To increase the likelihood of finding a compatible donor, kidney allocation systems prioritize highly sensitized patients to counterbalance the impact of HLA allo-sensitization and preclude…2017 American Transplant Congress
MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Background: Regulatory T cell (Tregs) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Although Treg suppression requires initial activation through cell…2017 American Transplant Congress
Effects of New KPD Histocompatibility Policy on Refusal Rate and Transplants.
Background: Transplant centers commonly refuse kidney paired donation (KPD) match offers due to unacceptable crossmatch (XM). To reduce XM refusals a new OPTN KPD histocompatibility…2017 American Transplant Congress
A Novel Computational HLA Matching Algorithm for Improving Donor-Recipient Histocompatibility and Graft Outcomes After Kidney Transplantation.
Introduction: Human Leukocyte Antigen (HLA) matching is a central objective of kidney allocation policies, but current assessment of histocompatibility is inadequate. Building on our previous…2017 American Transplant Congress
HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.
Pathology, Loyola University Medical Center, Maywood, IL
Aim: HLA-DP antibodies can elicit positive crossmatches and be detrimental in organ transplantation. Although HLA-DP unacceptable antigens can be input in the UNOS database, they…
- « Previous Page
- 1
- …
- 5
- 6
- 7
- 8
- 9
- Next Page »