Articles tagged "Histocompatibility"

2020 American Transplant Congress
Eplet Mismatch Imputed from HLA Serotype-Level Data Can Improve Risk Stratification for Kidney Allograft Loss
A. Heinzel, R. Reindl-Schwaighofer, A. Kainz, K. Hu, R. Oberbauer
Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
*Purpose: HLA-Epitope mismatch improves risk stratification following kidney transplantation. Based on population data, high resolution HLA types required for epitope prediction can be imputed based…
2020 American Transplant Congress
A Multicenter Analysis of the Proportion and Pattern of Unexplained HLA Antibodies in Kidney Recipients without a History of Sensitization
J. Lan¹, J. S. Gill¹, H. M. Gebel², R. A. Bray², R. Liwski³, A. Vinson⁴, A. Greenshields³, S. Dobrer⁵, O. Gunther⁵, K. Sherwood⁵, F. H. Claas⁶, S. Heidt⁶, G. Karahan⁶, J. Gill⁷, M. Gill¹, U. Varyani¹, P. Jindal¹, P. Keown⁵
¹Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, Emory University, Atlanta, GA, ³Pathology, Dalhousie University, Halifax, NS, Canada, ⁴Nephrology, Dalhousie University, Halifax, NS, Canada, ⁵Pathology, University of British Columbia, Vancouver, BC, Canada, ⁶Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands, ⁷Nephrology, Emory University, Atlanta, GA
*Purpose: Previous studies report a high prevalence of unexplained antibody reactivities on the single antigen bead (SAB) test. In a contemporary multicenter cohort of non-sensitized…
2020 American Transplant Congress
HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies
J. Lauronen¹, T. Jaatinen¹, J. Holgersson², C. Naper³, J. Peräsaari¹
¹Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland, ²Department of Laboratory Medicine, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, ³Histocompatibility Laboratory, Oslo University Hospital, Oslo, Norway
*Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…
2020 American Transplant Congress
The Clinical Relevance of cPRA in 0-ABDRDQ Mismatched Kidney Transplants
J. H. Lan¹, D. Chang¹, M. Kadatz¹, J. Gill¹, H. M. Gebel², J. S. Gill¹
¹Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, Emory University, Atlanta, GA
*Purpose: The clinical relevance of immune sensitization as measured by cPRA in kidney transplantation remains uncertain.*Methods: We identified 4,057 adult, first, kidney only transplant recipients…
2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
H. Sweiss¹, J. Lyons¹, D. Ranch², K. Hitchman², E. Kincaide¹, B. Crowther¹
¹University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
2019 American Transplant Congress
The Effect Of Exclusive Virtual Crossmatch To Allocate Deceased Donor Kidney Transplant On Cold Ischemia Time And Acute Rejection
E. Abuhelaiqa¹, M. Alkadi¹, S. Thappy¹, S. Saleh², J. Mahmoud³, M. Jarman³, O. Fituri¹, M. Elkhalifa⁴, J. Wadström³, H. Al-Malki¹
¹Medicine-Nephrology, Hamad Medical Corporation, Doha, Qatar, ²Histocompatibility & Immunogenetics Laboratory,, Hamad Medical Corporation, Doha, Qatar, ³Surgery-Transplant, Hamad Medical Corporation, Doha, Qatar, ⁴Histocompatibility & Immunogenetics Laboratory, Hamad Medical Corporation, Doha, Qatar
*Purpose: Virtual crossmatch (VXM) using Luminex single antigen bead has significantly improved prediction of an actual negative crossmatch. A negative crossmatch is typically required for…
2019 American Transplant Congress
Center-Level Variation in HLA-Incompatible Living Donor Kidney Transplantation Outcomes
K. Jackson¹, J. Long¹, K. Covarrubias¹, J. Motter¹, M. Bowring¹, J. Chen¹, M. Waldram¹, B. Orandi², N. Desai¹, A. Massie¹, D. Segev¹, J. Garonzik-Wang¹
¹Johns Hopkins University, Baltimore, MD, ²University of Alabama School of Medicine, Birmingham, AL
*Purpose: Desensitization protocols for HLA-incompatible living donor kidney transplantation (ILDKT) vary across centers. The impact of these variations, as well as other practice variations, on…
2019 American Transplant Congress
SIRPα Typing as a Potential Tool for Risk Stratification in Kidney Transplantation
A. Casillas-Abundis, A. Tambur, D. F. Pinelli, R. Hod-Dvorai, C. Garcia-Sanchez
Transplant Immunology Laboratory, Northwestern University, Chicago, IL
*Purpose: To determine if mismatches in the SIRPα receptor, associated with initiate innate alloresponses in animal models, may impact human kidney transplantation outcome.*Methods: To avoid…
2019 American Transplant Congress
Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model
J. Harmon, V. Korutla, L. Korutla, R. Hu, S. Rostami, A. Habertheuer, P. Zielinski, A. Freas, C. Ram, A. Naji, M. Davis, P. Vallabhajosyula
Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Exosomes are tissue specific, bilayered, membrane-bound nanoparticles released by many types of cells into bodily fluids including blood and urine. Exosomes carry protein and…
2019 American Transplant Congress
A2 To B Kidney Transplants Under Kidney Allocation System: A Prospective Study Of Anti A Titers And Correlation With Outcomes
H. Schaefer, I. Feurer, S. Rega, R. Forbes, D. Shaffer
Vanderbilt University, Nashville, TN
*Purpose: The UNOS KAS system incorporates A2 to B deceased donor kidney transplants (DDKTx) to improve access and reduce disparities in wait times for B…