Articles tagged "Histocompatibility"

2021 American Transplant Congress
Post-Transplant Outcomes Comparing A2 Incompatible to Compatible Deceased Donor Liver Transplant Recipients
T. Chiang, M. A. Eagleson, S. Bae, J. Garonzik-Wang, D. Segev, A. B. Massie
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Transplantation of A2 livers into type O and B recipients (A2i DDLT) is a growing modality to increase access to DDLT for O and…
2021 American Transplant Congress
The Calculated Panel of Incompatible Epitopes (cPIE) in the Service of Equitable Access to Transplantation
J. Lamsatfi¹, B. Bingfan Liu¹, S. Parto², A. Lewin³, K. Oualkacha¹, F. Claas⁴, P. Keown⁵, R. Sapir-Pichhadze⁶
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Hema-Quebec, Montreal, QC, Canada, ⁴Leiden University Medical Centre, Albinusdreef, Netherlands, ⁵University of British Columbia, Vancouver, BC, Canada, ⁶Medicine, McGill University Health Centre, Montreal, QC, Canada
*Purpose: To inform on feasibility of eplet matching, we developed the calculated Panel of Incompatible Epitopes (cPIE), an algorithm informing on the likelihood of identifying…
2021 American Transplant Congress
Blood Type A2/a2b to B Renal Transplantation: A Single Center Retrospective Cohort Study
V. S. Tatapudi, N. Alnazari, R. Chand, N. M. Ali, B. E. Lonze, R. A. Montgomery
NYU Langone Transplant Institute, NYU Langone Health, New York, NY
*Purpose: Blood type B candidates on the deceased donor kidney waitlist have a lower transplantation rate and longer wait time than candidates of other blood…
2021 American Transplant Congress
Use of a Novel Bead-based Assay to Measure the Impact of Imlifidase on ABO IgG Antibodies
A. Halpin¹, B. Motyka², T. Ellis², J. Pearcey², T. L. Lowary³, A. Runström⁴, L. Winstedt⁴, R. Bockermann⁴, S. Järnum⁴, A. Robertson⁴, L. J. West⁵
¹Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta and Alberta Precision Laboratories, Edmonton, AB, Canada, ²Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ⁴Hansa Biopharma, Lund, Sweden, ⁵Department of Pediatrics and Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: The accurate assessment and measurement of ABO antibodies (ABO-Ab) is a critical component of ABO-incompatible (ABOi) transplantation. ABO-Ab comprise both IgG and IgM, which…
2021 American Transplant Congress
Are All DSA’s the Same? Are We Ready for Precision Medicine in Pediatric LT?
S. E. Shin¹, M. Lee¹, N. Yazigi², K. Khan², S. Kaufman², J. Ahn³, O. Timofeeva⁴, U. Ekong²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC, ³Biostatistics, Bioinformatics, & Biomathematics, Georgetown University, Washington, DC, ⁴Histocompatibility Laboratory, Dept. of Pathology & Laboratory Medicine, Georgetown University, Washington, DC
*Purpose: Donor-specific antibodies (DSA) play an uncertain role in rejection after liver transplantation (LT). We hypothesized that evaluation of epitope differences in HLA-DR/DQ mismatching can…
2021 American Transplant Congress
Disparities in HLA Representation by Single Antigen Reagents in Different Ethnic Populations
J. C. Quon¹, J. Menteer², N. Fotiadis², R. M. Lestz², L. A. Baxter-Lowe²
¹Keck School of Medicine of USC, Los Angeles, CA, ²Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: It is not possible to test for antibodies against the antigens encoded by every HLA allele due to cost and throughput constraints. When alleles…
2021 American Transplant Congress
HLA Mismatching and Subclinical Inflammation: An Association to be Considered in Kidney Transplant Patients with Low Immunological Risk
T. Vazquez-Sanchez¹, J. Alonso-Titos¹, P. Ruiz-Esteban¹, A. Caballero², M. Leon³, V. Lopez¹, E. Sola¹, D. Hernández¹
¹Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, ²Immunology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, ³Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain
*Purpose: Subclinical inflammation (SCI) (
2020 American Transplant Congress
Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens
E. P. Kransdorf¹, C. Murphey², M. Maiers³, L. Gragert⁴
¹Cedars-Sinai Heart Institute, Beverly Hills, CA, ²Immunogenetics Lab, Southwest Immunodiagnostics, Inc., San Antonio, TX, ³Bioinformatics Research, Be The Match/National Marrow Donor Program, Minneapolis, MN, ⁴Department of Pathology, Tulane University School of Medicine, New Orleans, LA
*Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…
2020 American Transplant Congress
Are HLA-DQ De Novo Donor-Specific Antibodies a Risk Factor for Acute Humoral Rejection?
R. Hod Dvorai¹, C. A. Hubbell¹, M. R. Laftavi², R. Shahbazov², B. Gallay³, O. G. Pankewycz³
¹Pathology, SUNY Upstate Medical University, Syracuse, NY, ²Surgery, SUNY Upstate Medical University, Syracuse, NY, ³Medicine, SUNY Upstate Medical University, Syracuse, NY
*Purpose: To identify HLA-DQ de novo donor-specific antibodies (dnDSA) characteristics associated with acute humoral rejection (ABMR) and response to treatment.*Methods: We performed a retrospective analysis…
2020 American Transplant Congress
Impact of Catch-Up Vaccinations on Anti-HLA Antibody Responses in Pediatric Kidney Transplant Candidates
H. Sweiss¹, J. Lyons², R. Hall¹, K. Hitchman³, D. Ranch⁴, E. Kincaide¹, B. Crowther⁵
¹University Health System, San Antonio, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²Loyola University Medical Center, Chicago, IL, ³University Health System, San Antonio, TX, ⁴The University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁵University of Colorado Health, Aurora, CO
*Purpose: Evaluate antibody (Ab) response after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC less than or equal…