ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility antigens"

  • 2020 American Transplant Congress

    The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study

    A. Senev1, M. Coemans1, V. Van Sandt2, E. Van Loon1, J. Callemeyn1, B. Sprangers1, D. Kuypers1, M. Emonds1, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2HILA, Red Cross-Flanders, Mechelen, Belgium

    *Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…
  • 2020 American Transplant Congress

    Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation

    J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp

    University of Alabama-Birmingham, Birmingham, AL

    *Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…
  • 2020 American Transplant Congress

    Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens

    E. P. Kransdorf1, C. Murphey2, M. Maiers3, L. Gragert4

    1Cedars-Sinai Heart Institute, Beverly Hills, CA, 2Immunogenetics Lab, Southwest Immunodiagnostics, Inc., San Antonio, TX, 3Bioinformatics Research, Be The Match/National Marrow Donor Program, Minneapolis, MN, 4Department of Pathology, Tulane University School of Medicine, New Orleans, LA

    *Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…
  • 2020 American Transplant Congress

    HLA Diversity Affects Epitope Mismatch Cutoffs Utilized to Predict De Novo DSA Development and Graft Rejection in Renal Transplant Patients

    A. Ram1, S. Dhingra2, H. Quach1, P. T. Jindra1

    1Immune Evaluation Laboratory-Surgery, Baylor College of Medicine, Houston, TX, 2Pathology, Baylor College of Medicine, Houston, TX

    *Purpose: Recent studies have investigated epitope matching in order to determine its predictive power in determining renal transplant outcomes, both in terms of de novo…
  • 2020 American Transplant Congress

    HLA Specific Antibody Levels after EDTA Treatment in CDC Crossmatch Positive and Negative Sera with Known Donor-Specific Antibodies

    J. Lauronen1, T. Jaatinen1, J. Holgersson2, C. Naper3, J. Peräsaari1

    1Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland, 2Department of Laboratory Medicine, Sahlgrenska Academy at University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden, 3Histocompatibility Laboratory, Oslo University Hospital, Oslo, Norway

    *Purpose: Ethylenediaminetetraacetic acid (EDTA) treatment of serum samples overcomes the prozone effect that may interfere with solid phase HLA specific antibody analyses. In patients with…
  • 2020 American Transplant Congress

    MHC II-Decoy Car-T Cells to Induce Long-Term Allotransplant Organ Tolerance

    W. McCall1, T. Baybutt1, A. Snook1, A. Shah2

    1Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Philadelphia, PA, 2Department of Surgery, Division of Transplantation, Sidney Kimmel Medical College, Philadelphia, PA

    *Purpose: Allotransplantation represents the definitive therapy for end-stage renal, heart, liver, and lung disease. Current immunosuppressive regimens fail to promote long-term engraftment, leading to chronic…
  • 2020 American Transplant Congress

    Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk

    W. S. Oetting1, G. Weihua1, C. R. Dorr1, R. B. Mannon2, A. J. Matas1, P. A. Jacobson1, A. K. Israni1

    1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL

    *Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
  • 2019 American Transplant Congress

    Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates

    H. Sweiss1, J. Lyons1, D. Ranch2, K. Hitchman2, E. Kincaide1, B. Crowther1

    1University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 2University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX

    *Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
  • 2019 American Transplant Congress

    Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells

    T. Schachtner1, M. Stein2, N. M. Otto3, P. M. Reinke2

    1Nephrology, University Hospital Zurich, Zurich, Switzerland, 2Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, 3Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany

    *Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
  • 2019 American Transplant Congress

    Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation

    S. Kanangat1, I. Kurbegovic-Skaljic2, D. Cimbaluk2, M. Oppermann2, S. Jensik3, E. Hollinger3, O. Olaitan4, R. DeCresce2

    1Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, 2Pathology, Rush University Medical Center, Chicago, IL, 3Surgery, Rush University Medical Center, Chicago, IL, 4Tumor Immunology, Rush University Medical Center, Chicago, IL

    *Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…
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