Articles tagged "Heart/lung transplantation"

2017 American Transplant Congress
Antibodies to Angiotensin Type II Receptor I Are Associated with Primary Graft Dysfunction After Orthotopic Heart Transplant in Patients with Ventricular Assist Device as Bridge to Transplant.
M. Hickey,¹ E. DePasquale,² S. Shah,³ D. Vucicevic,² J. Zhang,¹ N. Valenzuela,¹ M. Deng,² E. Reed.¹
¹UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; ²UCLA Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA; ³UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA
Primary graft dysfunction (PGD) following orthotopic heart transplant (OHT) is one of the leading causes of posttransplant mortality. We hypothesized that antibody to angiotensin type…
2017 American Transplant Congress
TIE'ing Statins to Microvascular Stability and Endothelial Cell Immunogenicity.
C. Ghosh,¹ A. Mak,¹ M. McGourty,¹ S. Parikh,² X. Chen,² S. Goldberg,¹ J. Wedel,¹ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA; ²Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA
Graft microvascular endothelial cells (EC) represent a critical interface between the recipient and the donor. Stable/quiescent EC support immunoregulation in part via the expression of…
2017 American Transplant Congress
Increased Ischemic Inflammation Induces Recipient Endogenous Memory CD4 Cell-Graft Dendritic Cell Interactions to Provide Help for Activation of Endogenous Memory CD8 T Cells.
H. Tsuda, T. Tanaka, C. Su, A. Valujskikh, R. Fairchild.
Immunology, Cleveland Clinic, Cleveland, OH
Memory T cells provide protection against recurrent pathogens, but memory T cells with donor-reactivity pose a major barrier to successful allograft transplant and tolerance induction.…
2017 American Transplant Congress
Sequential Surgical Strategy for Heart-Kidney Transplantation.
D. Mital,¹ M. Petruccione,¹ J. Brown,¹ S. Vasquez,¹ S. Wheaton,¹ W. Johnson,¹ C. Desai,¹ D. Chhabra,¹ G. Kinzler,¹ H. Sankary,¹ T. Lawrecki,^1,2 P. Pappas,² A. Tatooles,² M. Bresticker,² W. Cotts,² G. Bhat.²
¹Kidney Transplant Program, General Surgery, Advocate Christ Medical Center, Oak Lawn, IL; ²Heart Failure and Transplant Program, Advocate Christ Medical Center, Oak Lawn, IL
Purpose: To describe a unique sequential surgical strategy for heart-kidney transplantation.Methods: We reviewed all 6 patients who received combined heart-kidney transplants at our institution between…
2017 American Transplant Congress
Routine Surveillance of Heart Transplant Recipients with Gene Expression Profiling: Lack of an Impact of Race on Outcomes.
J. Teuteberg,¹ M. Shullo,¹ D. Rinde-Hoffman,² M. Wigger,³ Y. Wang,⁴ T. Wolf,⁴ P. Arnold,⁴ J. Sninsky,⁴ P. Berman.²
¹University of Pittsburgh Medical Center, Pittsburgh, PA; ²Tampa General Hospital, Tampa, FL; ³Vanderbilt Heart and Vascular Institution, Nashville, TN; ⁴CareDx, Brisbane, CA
Purpose: Patients of African descent have been reported to have less favorable outcomes after heart transplantation than patients of European descent. However, the impact of…
2017 American Transplant Congress
In the Modern Era, Cytomegalovirus Does Not Appear to Increase Intimal Thickening After Heart Transplantation.
D. Leong, B. Azarbal, J. Patel, M. Kittleson, L. Czer, T. Aintablian, D. Chang, D. Geft, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Cytomegalovirus (CMV) has been associated with the subsequent development of cardiac allograft vasculopathy (CAV) after heart transplantation. In the more recent era, CMV has…
2017 American Transplant Congress
Does the Model for End Stage Liver Disease (MELD) Score Predict Outcome in Total Artificial Heart Patients?
M. Rafiei, J. Moriguchi, M. Kittleson, J. Patel, T. Aintablian, E. Passano, R. Sharoff, J. Kwan, E. Kransdorf, D. Chang, L. Czer, J. Kobashigawa, F. Arabia.
Cedars-Sinai Heart Institute, Los Angeles
The total artificial heart (TAH) is being used for biventricular failure in patients with severe heart disease. Patients(pts) who have received a left ventricular assist…
2017 American Transplant Congress
Simultaneous Heart and Kidney Transplant vs Heart Transplant: Single Center Review of Candidate Selection and List Management.
N. Fonseka,¹ H. Mangrolia,¹ S. Karhadkar,² S. Rao,² L. Punnoose.¹
¹Temple Heart and Vascular Institute, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; ²Temple Kidney Transplant Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
Background: Increasing numbers of patients with advanced heart and kidney failure undergo simultaneous heart kidney transplant (SHK). Selection criteria in patients with non-dialysis dependent kidney…
2017 American Transplant Congress
Severe Tricuspid Regurgitation After Heart Transplantation: Does It Require Surgical Repair?
J. Patel, M. Kittleson, L. Czer, T. Aintablian, R. Sharoff, R. Levine, A. Velleca, D. Ramzy, F. Esmailian, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Tricuspid regurgitation (TR) after heart transplantation is common. Causes for TR may be due to volume overload, flail tricuspid leaflet from endomyocardial biopsy, pulmonary…
2017 American Transplant Congress
Preventing Alloimmune Rejection in Heart Transplantation by Tolerogenic Dendritic Cells Induced by GDF15 Through Up-Regulation of IDO and Inhibition of the NFκB Signalling Pathway.
Y. Zhang,^1,3 G. Zhang,¹ L. Moszczynski,¹ D. Zhao,^1,3 P. Abulizi,¹ D. Quan,² T. Mele,² K. Liu,³ X. Zheng.^1,2
¹Pathology, University of Western Ontario, London, ON, Canada; ²Surgery, University of Western Ontario, London, ON, Canada; ³Cardiovascular Surgery, Jilin University, Cahngchun, China
Rationale: Growth differentiation factor 15 (GDF15) can inhibit DC maturation, yet whether it can generate tolerogenic dendritic cells (Tol-DCs) to induce immune tolerance in heart…