Articles tagged "Heart/lung transplantation"

2017 American Transplant Congress
Routine Surveillance of Heart Transplant Recipients with Gene Expression Profiling: Lack of an Impact of Race on Outcomes.
J. Teuteberg,¹ M. Shullo,¹ D. Rinde-Hoffman,² M. Wigger,³ Y. Wang,⁴ T. Wolf,⁴ P. Arnold,⁴ J. Sninsky,⁴ P. Berman.²
¹University of Pittsburgh Medical Center, Pittsburgh, PA; ²Tampa General Hospital, Tampa, FL; ³Vanderbilt Heart and Vascular Institution, Nashville, TN; ⁴CareDx, Brisbane, CA
Purpose: Patients of African descent have been reported to have less favorable outcomes after heart transplantation than patients of European descent. However, the impact of…
2017 American Transplant Congress
In the Modern Era, Cytomegalovirus Does Not Appear to Increase Intimal Thickening After Heart Transplantation.
D. Leong, B. Azarbal, J. Patel, M. Kittleson, L. Czer, T. Aintablian, D. Chang, D. Geft, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Cytomegalovirus (CMV) has been associated with the subsequent development of cardiac allograft vasculopathy (CAV) after heart transplantation. In the more recent era, CMV has…
2017 American Transplant Congress
Does the Model for End Stage Liver Disease (MELD) Score Predict Outcome in Total Artificial Heart Patients?
M. Rafiei, J. Moriguchi, M. Kittleson, J. Patel, T. Aintablian, E. Passano, R. Sharoff, J. Kwan, E. Kransdorf, D. Chang, L. Czer, J. Kobashigawa, F. Arabia.
Cedars-Sinai Heart Institute, Los Angeles
The total artificial heart (TAH) is being used for biventricular failure in patients with severe heart disease. Patients(pts) who have received a left ventricular assist…
2017 American Transplant Congress
Simultaneous Heart and Kidney Transplant vs Heart Transplant: Single Center Review of Candidate Selection and List Management.
N. Fonseka,¹ H. Mangrolia,¹ S. Karhadkar,² S. Rao,² L. Punnoose.¹
¹Temple Heart and Vascular Institute, Lewis Katz School of Medicine at Temple University, Philadelphia, PA; ²Temple Kidney Transplant Program, Lewis Katz School of Medicine at Temple University, Philadelphia, PA
Background: Increasing numbers of patients with advanced heart and kidney failure undergo simultaneous heart kidney transplant (SHK). Selection criteria in patients with non-dialysis dependent kidney…
2017 American Transplant Congress
Severe Tricuspid Regurgitation After Heart Transplantation: Does It Require Surgical Repair?
J. Patel, M. Kittleson, L. Czer, T. Aintablian, R. Sharoff, R. Levine, A. Velleca, D. Ramzy, F. Esmailian, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Tricuspid regurgitation (TR) after heart transplantation is common. Causes for TR may be due to volume overload, flail tricuspid leaflet from endomyocardial biopsy, pulmonary…
2017 American Transplant Congress
Preventing Alloimmune Rejection in Heart Transplantation by Tolerogenic Dendritic Cells Induced by GDF15 Through Up-Regulation of IDO and Inhibition of the NFκB Signalling Pathway.
Y. Zhang,^1,3 G. Zhang,¹ L. Moszczynski,¹ D. Zhao,^1,3 P. Abulizi,¹ D. Quan,² T. Mele,² K. Liu,³ X. Zheng.^1,2
¹Pathology, University of Western Ontario, London, ON, Canada; ²Surgery, University of Western Ontario, London, ON, Canada; ³Cardiovascular Surgery, Jilin University, Cahngchun, China
Rationale: Growth differentiation factor 15 (GDF15) can inhibit DC maturation, yet whether it can generate tolerogenic dendritic cells (Tol-DCs) to induce immune tolerance in heart…
2017 American Transplant Congress
Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, J. Zhang, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate…
2017 American Transplant Congress
Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.
T. Maehana, T. Tanaka, N. Masumori.
Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…
2017 American Transplant Congress
B Cell-Derived Cytokines Rather Than T/B Cognate Interactions Mediate CD8 T Cell Reconstitution Following Lymphoablation.
D. Zwick, K. Ayasoufi, R. Fan, V. Gorbacheva, K. Keslar, R. Fairchild, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH
Antibody-mediated lymphoablation is a commonly used induction therapy in sensitized transplant recipients. Using murine anti-thymocyte globulin (mATG) in a model of BALB/c (H-2d) to B6…
2017 American Transplant Congress
The Ultimate Calculated Panel Reactive Antibody Value Predicts Mortality After Heart Transplantation.
E. Kransdorf,¹ M. Kittleson,¹ J. Patel,¹ M. Pando,² L. Czer,¹ J. Kobashigawa.¹
¹Cedars-Sinai Heart Institute, Los Angeles; ²Mayo Clinic Arizona, Phoenix
Background: Sensitized heart transplant (HT) candidates are known to be at higher risk for adverse events after transplantation, including a positive crossmatch, rejection, and death.…