ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart/lung transplantation"

  • 2022 American Transplant Congress

    p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts

    H. Tsuda1, A. Valujskikh2, R. Fairchild3

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2The Cleveland Clinic Fdn, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
  • 2022 American Transplant Congress

    Anti-CD80/86 Antibody (RM80/GL-1) Suppressed Murine Donor Specific Antibody Through Anergy CD4+T Cells

    Y. Yamamoto1, K. Uchida2, K. Iguchi1, M. Niimi3, M. Uchiyama1

    1Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan, 2Juntendo University, Tokyo, Japan, 3Department of Surgery, Teikyo University, Tokyo, Japan

    *Purpose: The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells may play an important role in alloimmune responses. We investigated…
  • 2022 American Transplant Congress

    Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients

    A. E. Woolley, N. Sharma, G. Zhou, A. Kim, E. Ryan, M. Joyce, H. Goldberg, M. Givertz, M. Mehra, E. Woodcome, V. Durney, S. Marshall, K. Townsend, A. Coppolino, S. Tullius, S. Malek, H. Mallidi, L. Baden, A. Chandraker

    Brigham & Women's Hospital, Boston, MA

    *Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…
  • 2022 American Transplant Congress

    Role of Group 2 Innate Lymphoid Cells in Murine Heart Transplant

    J. Ge1, L. Ott1, A. Das1, J. Markmann2, A. Cuenca1

    1Department of Surgery, Boston Children's Hospital, Boston, MA, 2Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Group 2 innate lymphoid cells (ILC2s) have been shown to play key roles in manipulating adaptive immunity. They regulate CD4+ T cell biology not…
  • 2022 American Transplant Congress

    Life Supporting Orthotopic Cardiac Xenotransplantation Using Multiple Human Gene Expressing Pigs in Non Human Primates

    A. K. Singh1, C. Goerlich1, T. Zhang1, I. Tatarov1, P. Odonkor1, E. Strauss1, B. Williams1, B. Lewis1, A. Hershfeld1, F. Sentz1, D. Ayares2, D. Kaczorowski1, B. Griffith1, M. Mohiuddin1

    1Department of Surgery, University of Maryland, Baltimore, MD, 2Revivicor Inc, Blacksburg, WV

    *Purpose: Cardiac xenotransplantation (CXTx) is proposed as an alternate treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically engineered (GE) pig…
  • 2022 American Transplant Congress

    Perioperative IL-6 Blockade Promotes Intra-Graft Regulation and Prevents Costimulation-Blockade Resistant Rejection

    M. Muckenhuber1, K. Mengrelis1, A. M. Weijler1, V. Kainz1, R. Steiner1, H. Regele2, T. Wekerle1

    1Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, 2Dept. of Pathology, Medical University of Vienna, Vienna, Austria

    *Purpose: Our group has recently shown that CTLA4-Ig monotherapy leads to limited murine heart allograft survival associated with decreased Treg frequencies and early acute T-cell…
  • 2022 American Transplant Congress

    Presence of Infiltrating Regulatory T Cells in the Cardiac Xenografts and Their Potential Role in Graft Survival

    A. K. Singh1, C. E. Goerlich1, G. Braileanu1, A. Hershfeld1, T. Zhang1, I. Tatarov1, B. Lewis1, F. Sentz1, D. Ayares2, B. Griffith1, M. M. Mohiuddin1

    1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor Inc, Blacksburg, WV

    *Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
  • 2022 American Transplant Congress

    Current State of Use of Hepatitis C Viremic Donor Organs in Negative Recipients in the United States: A National Survey

    K. Ryland1, K. Hattori2, J. Steinbrink3, N. Theodoropoulos4, M. Ison5

    1Mayo Clinic, Jacksonville, FL, 2Duke university hospital, Durham, NC, 3Duke University, Durham, NC, 4University of Massachusetts Medical School, Worcester, MA, 5Northwestern University Comprehensive Transplant Center, Chicago, IL

    *Purpose: Since the advent of direct-acting antiviral (DAA) therapy, use of hepatitis C (HCV) viremic donor organs in HCV negative recipients has become more common.…
  • 2022 American Transplant Congress

    The Post-operative Clinical Outcomes Of 59 Tanrp Cases In An International Cohort

    J. Louca1, N. Patel1, S. Messer2, J. Chindu2, S. Large2

    1Cambridge University, Cambridge, United Kingdom, 2Royal Papworth Hospital, Cambridge, United Kingdom

    *Purpose: Heart transplantation is an immensely effective service and is currently the only definitive treatment for heart failure. However, transplantation is limited by donor availability.…
  • 2022 American Transplant Congress

    Cardiomyocyte Cross-Sectional Area Increases After Orthotopic Cardiac Xenotransplantation and is Not Likely a Significant Contributor to Xenograft Growth up to 9 Months

    C. E. Goerlich1, B. Griffith1, J. Treffalls1, P. Hanna2, S. N. Hong2, A. K. Singh1, D. Ayares3, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, 3Revivicor, Inc., Blacksburg, VA

    *Purpose: Genetically engineered (GE) pigs are thought to be an alternative organ source for patients in end-stage heart failure unable to receive a timely allograft.…
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