Articles tagged "Heart/lung transplantation"

2017 American Transplant Congress
B Cell-Derived Cytokines Rather Than T/B Cognate Interactions Mediate CD8 T Cell Reconstitution Following Lymphoablation.
D. Zwick, K. Ayasoufi, R. Fan, V. Gorbacheva, K. Keslar, R. Fairchild, A. Valujskikh.
Immunology, Cleveland Clinic, Cleveland, OH
Antibody-mediated lymphoablation is a commonly used induction therapy in sensitized transplant recipients. Using murine anti-thymocyte globulin (mATG) in a model of BALB/c (H-2d) to B6…
2017 American Transplant Congress
The Ultimate Calculated Panel Reactive Antibody Value Predicts Mortality After Heart Transplantation.
E. Kransdorf,¹ M. Kittleson,¹ J. Patel,¹ M. Pando,² L. Czer,¹ J. Kobashigawa.¹
¹Cedars-Sinai Heart Institute, Los Angeles; ²Mayo Clinic Arizona, Phoenix
Background: Sensitized heart transplant (HT) candidates are known to be at higher risk for adverse events after transplantation, including a positive crossmatch, rejection, and death.…
2017 American Transplant Congress
Expression of Injury and Repair Genes in Ex Vivo Perfused Swing Lung Transplants.
P. Dromparis,¹ S. Wagner,¹ N. Aboelnaz,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Surgery (Cardiac Surgery), University of Alberta, Edmonton, Canada
Due to acute lung injury (ALI), only 20% of donated lungs are suitable for transplant and of those, 25% develop primary graft dysfunction. Ex vivo…
2017 American Transplant Congress
Validation of a Prediction Model for Cardiac Allograft Vasculopathy.
E. Kransdorf, T. Aintablian, M. Kittleson, J. Patel, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Introduction: Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of heart transplantation. Although the progression of CAV can be slowed by tailored immunosuppression,…
2017 American Transplant Congress
Antibodies to Angiotensin Type II Receptor I Are Associated with Primary Graft Dysfunction After Orthotopic Heart Transplant in Patients with Ventricular Assist Device as Bridge to Transplant.
M. Hickey,¹ E. DePasquale,² S. Shah,³ D. Vucicevic,² J. Zhang,¹ N. Valenzuela,¹ M. Deng,² E. Reed.¹
¹UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; ²UCLA Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA; ³UCLA David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA
Primary graft dysfunction (PGD) following orthotopic heart transplant (OHT) is one of the leading causes of posttransplant mortality. We hypothesized that antibody to angiotensin type…
2017 American Transplant Congress
TIE'ing Statins to Microvascular Stability and Endothelial Cell Immunogenicity.
C. Ghosh,¹ A. Mak,¹ M. McGourty,¹ S. Parikh,² X. Chen,² S. Goldberg,¹ J. Wedel,¹ D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA; ²Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA
Graft microvascular endothelial cells (EC) represent a critical interface between the recipient and the donor. Stable/quiescent EC support immunoregulation in part via the expression of…
2017 American Transplant Congress
Increased Ischemic Inflammation Induces Recipient Endogenous Memory CD4 Cell-Graft Dendritic Cell Interactions to Provide Help for Activation of Endogenous Memory CD8 T Cells.
H. Tsuda, T. Tanaka, C. Su, A. Valujskikh, R. Fairchild.
Immunology, Cleveland Clinic, Cleveland, OH
Memory T cells provide protection against recurrent pathogens, but memory T cells with donor-reactivity pose a major barrier to successful allograft transplant and tolerance induction.…
2017 American Transplant Congress
Sequential Surgical Strategy for Heart-Kidney Transplantation.
D. Mital,¹ M. Petruccione,¹ J. Brown,¹ S. Vasquez,¹ S. Wheaton,¹ W. Johnson,¹ C. Desai,¹ D. Chhabra,¹ G. Kinzler,¹ H. Sankary,¹ T. Lawrecki,^1,2 P. Pappas,² A. Tatooles,² M. Bresticker,² W. Cotts,² G. Bhat.²
¹Kidney Transplant Program, General Surgery, Advocate Christ Medical Center, Oak Lawn, IL; ²Heart Failure and Transplant Program, Advocate Christ Medical Center, Oak Lawn, IL
Purpose: To describe a unique sequential surgical strategy for heart-kidney transplantation.Methods: We reviewed all 6 patients who received combined heart-kidney transplants at our institution between…
2017 American Transplant Congress
Routine Surveillance of Heart Transplant Recipients with Gene Expression Profiling: Lack of an Impact of Race on Outcomes.
J. Teuteberg,¹ M. Shullo,¹ D. Rinde-Hoffman,² M. Wigger,³ Y. Wang,⁴ T. Wolf,⁴ P. Arnold,⁴ J. Sninsky,⁴ P. Berman.²
¹University of Pittsburgh Medical Center, Pittsburgh, PA; ²Tampa General Hospital, Tampa, FL; ³Vanderbilt Heart and Vascular Institution, Nashville, TN; ⁴CareDx, Brisbane, CA
Purpose: Patients of African descent have been reported to have less favorable outcomes after heart transplantation than patients of European descent. However, the impact of…
2017 American Transplant Congress
In the Modern Era, Cytomegalovirus Does Not Appear to Increase Intimal Thickening After Heart Transplantation.
D. Leong, B. Azarbal, J. Patel, M. Kittleson, L. Czer, T. Aintablian, D. Chang, D. Geft, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Cytomegalovirus (CMV) has been associated with the subsequent development of cardiac allograft vasculopathy (CAV) after heart transplantation. In the more recent era, CMV has…