ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart/lung transplantation"

  • 2017 American Transplant Congress

    Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.

    G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, J. Zhang, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate…
  • 2016 American Transplant Congress

    Liver Evaluation for Heart Transplantation: Which Is Better, Noninvasive Scans or Liver Biopsy?

    R. Mohan, J. Patel, M. Kittleson, D. Chang, T. Aintablian, L. Czer, F. Esmailian, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Background: Patients awaiting heart transplantation who have known liver disease from congestive hepatopathy are at increased risk for mortality post-transplantation. The evaluation of the liver…
  • 2016 American Transplant Congress

    Rituximab Induction in Cardiac Transplantation Is Associated with Accelerated Coronary Artery Vasculopathy: CTOT11.

    A. Chandraker, J. Kobashigawa, J. Stehlik, M. Givertz, R. Pierson, S. Pinney, M. Joren, S. Nissen, I. Guleria, Y. Morrison, B. Armstrong, N. Bridges, M. Sayegh, R. Starling.

    On Behalf of the CTOT11 Consortium, Brigham & Women's Hospital, Boston, MA.

    PurposeThe NIH-funded study CTOT11: Prevention of Cardiac Allograft Vasculopathy Using Rituximab (RIT) Therapy in Cardiac Transplantation, was a randomized clinical trial in non-sensitized primary heart…
  • 2016 American Transplant Congress

    Comparison of Actual versus Goal Tacrolimus Levels Post Cardiothoracic Transplant.

    E. Milas, I. Feurer, C. Truscott, J. Gray, N. Wilson, S. Bala, T. Dreher, M. Wigger, M. Steele, A. Shah, E. Lambright, D. Hanto.

    Vanderbilt Transplant Center, Nashville, TN.

    BackgroundAlthough target tacrolimus (TAC) trough levels necessary to prevent rejection are established post heart/lung transplant (tx), there is little published literature on the proportion of…
  • 2016 American Transplant Congress

    Fatty Liver in Non-Hepatic Organ Transplantation.

    N. Kemmer, A. Alsina.

    Tampa General Medical Group, Tampa, FL.

    With the availability of effective antiviral regimen for HCV, Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries and…
  • 2016 American Transplant Congress

    Cytomegalovirus Infection After Cardiac Transplantation.

    O. Kiamanesh, A. Khosla, C. Imai, E. Johansson, S. Virani, M. Davis, A. Cheung, J. Bashir, B. Munt, A. Ignaszewski, A. Kaan, M. Toma.

    University of British Columbia, Vancouver, Canada.

    BackgroundOrthotopic heart transplantation (OHT) continues to be the gold standard for the management of patients with end-stage heart failure. However, complications following OHT may result…
  • 2016 American Transplant Congress

    The Increase of Serum MiR-142-3p Level in Acute Cardiac Rejection as a Reflection of Exosome-Mediated Genetic Exchange Between T Cells and Endothelial Cells.

    I. Dewi,1 Z. Hollander,2 B. McManus,2 O. Gidlöf,1 J. Öhman.1

    1Cardiology, Lund University, Lund, Sweden; 2PROOF Center of Excellence, Vancouver, Canada.

    IntroductionIn the recent years, microRNAs has emerged as the popular biomarker candidate in the field of solid organ transplantation due to their expression patterns reflect…
  • 2016 American Transplant Congress

    Necroptosis Is Involved in CD4+ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.

    C. Kwok,1,2 N. Montwill,1,2 A. Pavlosky,1,2 A. Haig,2 X.-Y. Huang,1 A. Jevnikar,1,3 Z.-X. Zhang.1,2,3

    1Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada; 2Department of Pathology and Laboratory Medicine, Western University, London, Canada; 3Department of Medicine, Western University, London, Canada.

    Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…
  • 2016 American Transplant Congress

    CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

    J. Burg,1 T. Andoh,2 N. Haese,2 C. Kreklywich,2 K. Watters,3 T. Metz,3 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR; 3Biological Sciences Division, PNNL, Richland, WA.

    PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…
  • 2016 American Transplant Congress

    The Impact of Sequential Gene Modifications on Cardiac Xenograft Survival.

    K. Horvath,1 A. Singh,1 J. Chan,1 M. Thomas,2 B. Lewis,2 D. Ayares,3 P. Corcoran,1 M. Mohiuddin.1

    1CSRP, NHLBI/NIH, Bethesda, MD; 2DVR / ORS, NIH, Bethesda, MD; 3Revivicor, Inc, Blacksburg, VA.

    Introduction: One of the major advances in xenotransplantation is the ability to modify donor pig genetics. Using rapidly evolving techniques of pig cloning and gene…
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