2016 American Transplant Congress
The Impact of Sequential Gene Modifications on Cardiac Xenograft Survival.
1CSRP, NHLBI/NIH, Bethesda, MD; 2DVR / ORS, NIH, Bethesda, MD; 3Revivicor, Inc, Blacksburg, VA.
Introduction: One of the major advances in xenotransplantation is the ability to modify donor pig genetics. Using rapidly evolving techniques of pig cloning and gene…2016 American Transplant Congress
CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.
PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…2016 American Transplant Congress
Necroptosis Is Involved in CD4+ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.
Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…2016 American Transplant Congress
The Increase of Serum MiR-142-3p Level in Acute Cardiac Rejection as a Reflection of Exosome-Mediated Genetic Exchange Between T Cells and Endothelial Cells.
1Cardiology, Lund University, Lund, Sweden; 2PROOF Center of Excellence, Vancouver, Canada.
IntroductionIn the recent years, microRNAs has emerged as the popular biomarker candidate in the field of solid organ transplantation due to their expression patterns reflect…2016 American Transplant Congress
Cytomegalovirus Infection After Cardiac Transplantation.
University of British Columbia, Vancouver, Canada.
BackgroundOrthotopic heart transplantation (OHT) continues to be the gold standard for the management of patients with end-stage heart failure. However, complications following OHT may result…2016 American Transplant Congress
Fatty Liver in Non-Hepatic Organ Transplantation.
Tampa General Medical Group, Tampa, FL.
With the availability of effective antiviral regimen for HCV, Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries and…2016 American Transplant Congress
Comparison of Actual versus Goal Tacrolimus Levels Post Cardiothoracic Transplant.
Vanderbilt Transplant Center, Nashville, TN.
BackgroundAlthough target tacrolimus (TAC) trough levels necessary to prevent rejection are established post heart/lung transplant (tx), there is little published literature on the proportion of…2015 American Transplant Congress
Liver Allograft Provides Immunoprotection for the Cardiac Allograft in Combined Heart-Liver Transplantation
When transplanted simultaneously, the liver allograft has been thought to have an immunoprotective role on other organs. However, detailed studies on simultaneous heart-liver transplantation (SHLT)…2015 American Transplant Congress
Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…2015 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
American Transplant Congress abstracts