Articles tagged "Heart"

2019 American Transplant Congress
Absence of Antibodies in Human Neonates and Infants to Gtko/cmahko/β4galnt2ko (Triple Gene Knockout) Pig Cells: Relevance to Cardiac Xenotransplantation for Complex Congenital Heart Disease
H. Hara¹, Q. Li¹, C. A. Banks¹, T. Yamamoto¹, D. Ayares², D. C. Cleveland¹, D. K. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Revivicor Inc., Blacksburg, VA
*Purpose: Heart transplantation (Tx) in neonates is associated with the best results of any organ Tx, but the lack of deceased human donor hearts in…
2019 American Transplant Congress
Development of Non-Human Leukocyte Antigen Antibodies in Cardiac Antibody-Mediated Rejection
S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino¹, P. C. Colombo³, L. J. Addonizio², M. A. Farr³, E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Division of Cardiology, Columbia University, New York, NY, ⁴Immucor, Georgia, GA, ⁵Department of Pathology and Cell Biology, Columbia University, New York, NY, ⁶Department of Surgery, Columbia University, New York, NY
*Purpose: Antibody-mediated rejection (AMR), mainly driven by the development of donor-specific antibodies (DSA) directed against mismatched donor class I and class II HLA, is a…
2019 American Transplant Congress
Hepatocellular Carcinoma in Fontan Liver Disease
V. Lamm¹, J. Wedd², C. Haydek², C. Obineme², A. Noll², H. Veeramachaneni², M. Muftah², R. Ford²
¹Internal Medicine, Emory, Atlanta, GA, ²Emory, Atlanta, GA
*Purpose: To add to the clinical characteristics and outcomes of hepatocellular carcinoma (HCC) in post Fontan operation patients and present, to the best of our…
2019 American Transplant Congress
Risk Stratification of Patients Undergoing Simultaneous Liver Transplantation and Cardiac Surgery
T. Diago Uso, G. D'Amico, S. Armanyous, L. Lomaglio, B. Eghtesad, M. Fujiki, F. Aucejo, K. Sasaki, N. K. Menon, M. Fares, M. Tong, K. Hashimoto, C. Miller, C. Quintini
Cleveland Clinic, Cleveland, OH
*Purpose: Evaluate risk factors and outcomes of combined liver transplantation (OLT) and cardiac surgery, including coronary artery grafting and valve replacement.*Methods: Between 1/2005 and 8/2018,…
2019 American Transplant Congress
Immunosuppressant Adherence in Adult Heart Transplant Recipients: An Analysis of Pharmacy Claims and Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, A. R. Wilk¹, J. Maghirang¹, E. A. Witt², H. Kirkham³, S. Boghani², N. Hira⁴, G. Pietradoni², D. K. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²Walgreens Co, Deerfield, IL, ³Walgreens Co, Deerfied, IL, ⁴AllianceRx Walgreens Prime, Orlando, FL
*Purpose: The current study was conducted to determine characteristics that are associated with immunosuppressant (IS) medication adherence among adult recipients of deceased donor heart transplants…
2019 American Transplant Congress
Statin Underutilization in Patients Listed for Liver Transplant
K. Mishra¹, S. Naffouj¹, S. Modi¹, C. Dagher¹, S. Gorgis¹, D. Venkat²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI, ²Transplant Hepatology, Henry Ford Hospital, Detroit, MI
*Purpose: Current guidelines recommend statin use in high risk patients based on the ASCVD (atherosclerotic cardiovascular disease) score, diabetes, or LDL levels. Despite several trials…
2019 American Transplant Congress
Donor Brain Death Affects Tolerance Induction in Non-Human Primates
W. Sommer¹, J. M. O², K. B. Pruner³, J. T. Paster³, A. Bean³, A. Dehnadi³, I. M. Hanekamp³, I. Rosales⁴, R. N. Smith⁴, R. B. Colvin⁴, G. Benichou³, J. S. Allan³, T. Kawai³, J. C. Madsen⁵
¹Department of Cardiothoracic Surgery, Hannover Medical School, Hannover, Germany, ²Center for Transplantation Sciences, Massachusets General Hospital, Boston, MA, ³Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁴Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁵Center fro Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Induction of durable allograft acceptance in combined heart/kidney transplantation in non-human primates is possible by applying a mixed chimerism-based conditioning protocol. However, the impact…
2019 American Transplant Congress
Prevalence of Donor Specific Antibody in Heart Transplant Recipients with Antibody-Mediated Rejection as Compared to Abnormal Intragraft mRNA Transcripts by Molecular Microscope System
K. Shah, R. J. Levine, S. Dimbil, S. Sana, P. F. Halloran, J. Patel, D. H. Chang, E. Kransdorf, M. Kittleson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) is defined by pathologic evaluation of endomyocardial biopsy (EMB) for both histologic and immunopathologic components. Detectable donor specific antibodies (DSAs) in…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
2019 American Transplant Congress
Unfair Waiting Time Calculation? Impact of Accumulated Wait Time Restart with a Decrease in Status from 1A to 1B or 2 on Mortality of Heart Transplant Candidates
S. Yu, M. Kosztowski, M. Waldram, D. L. Segev, A. B. Massie
Department of Surgery, Johns Hopkins, Baltimore, MD
*Purpose: Between two heart transplant (HT) candidates listed at the same status, the candidate with longer accumulated wait time receives higher waitlist priority; under current…