ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

­Pediatric Heart and Lung Graft Loss during the “High-Risk Age Window”

J. Long1, J. Motter1, K. R. Jackson1, M. Kosztowski1, B. Orandi2, X. Luo1, K. Van Arendonk3, A. Massie1, E. Bush1, R. S. Higgins1, D. L. Segev1, J. M. Garonzik-Wang1

1Johns Hopkins School of Medicine, Baltimore, MD, 2University Of Alabama at Birmingham, Birmingham, AL, 3Children’s Hospital of Wisconsin-Milwaukee Campus, Milwaukee, WI

Meeting: 2019 American Transplant Congress

Abstract number: C343

Keywords: Graft survival, Heart, Lung, Pediatric

Session Information

Date: Monday, June 3, 2019

Session Name: Poster Session C: Lung: All Topics

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

Related Abstracts
  • High-Risk Age Window for Graft Loss in Pediatric Lung and Heart Transplant Recipients.
  • Loss of Pediatric Kidney Grafts during the "High-Risk Age Window": Insights from Liver Recipients

*Purpose: Pediatric kidney transplant recipients experience a high-risk age window of increased graft loss during late adolescence and early adulthood (17-24 years), termed emerging adulthood. Previously, this high-risk age window had been attributed to primarily sociobehavioral factors such as nonadherence. Since pediatric heart and lung transplant recipients undergo a similar transition, we examined if they were also at increased risk for graft-loss during emerging adulthood.

*Methods: Using registry data from SRTR from 1987 to 2018, we estimated all-cause graft loss at current recipient age among 1198 lung and 7997 heart pediatric transplant recipients using piecewise-constant hazard rate regressions. In both models, we adjusted for year of transplant as well as donor and recipient characteristics. Combined heart-lung transplant recipients were excluded.

*Results: Pediatric lung transplant recipients were more likely to experience graft loss between 17-24 years of age compared to those <17 (aHR=1.14 1.34 1.58, p<0.001) and >24 (aHR=2.03 2.87 4.06, p<0.001) (Figure, A). However, among heart transplant recipients, the high-risk age window for graft was between 0-3 years of age, compared to ages 3-17 (aHR= 0.48 0.55 0.63, p<0.001), 17-24 (aHR=0.67 0.78 0.92, p=0.003), and >24 (aHR=0.45 0.55 0.67, p<0.001) (Figure, B).

*Conclusions: Emerging adulthood is a high-risk period for pediatric lung transplant recipients, but it is not characterized by an increased risk of graft loss for pediatric heart transplant recipients. These findings suggest that sociobehavioral factors alone do not fully account for the high-risk age window and that other biologic etiologies should be considered.

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Long J, Motter J, Jackson KR, Kosztowski M, Orandi B, Luo X, Arendonk KVan, Massie A, Bush E, Higgins RS, Segev DL, Garonzik-Wang JM. ­Pediatric Heart and Lung Graft Loss during the “High-Risk Age Window” [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/pediatric-heart-and-lung-graft-loss-during-the-high-risk-age-window/. Accessed January 19, 2021.

« Back to 2019 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Home
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.