Articles tagged "Graft acceptance"

2017 American Transplant Congress
Utility of IL-2 Complexes in Promoting Vascularized Composite Allograft Survival.
H. Xu,¹ S. Dahiya,² L. Wang,² T. Akimova,² W. Hancock,^2,4 S. Levin.³
¹Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ³Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
Vascularized composite allografts (VCA) are a novel, life-enhancing form of transplantation (Tx). The complexity of host immune responses to VCA tissues, especially those involving skin,…
2017 American Transplant Congress
Early Evolution and Immunopathologic Phenotype of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts.
C. Yang,¹ I. Rosales,² E. Farkash,³ D. Ndishabandi,^1,3 R. White,³ P. Russell,¹ J. Madsen,¹ A. Alessandrini,^1,3 R. Colvin.^1,3
¹Center for Transplantation Sciences, Mass General Hospital, Boston, MA; ²Department of Pathology, Mass General Hospital, Boston, MA; ³Department of Pathology, University of Michigan, Ann Arbor, MI
Introduction: Lymphoid neogenesis has been found in allografts after organ transplant. We previously reported that spontaneously accepted DBA/2 to B6 kidney allografts developed distinctive, peri-arterial…
2017 American Transplant Congress
“Donor Age or Quality” a Qualitative Analysis of Livers Declined for 830.
M. Dokus, E. DeAngelis, G. Ramaraju, K. Tomiyama, J. Huang, M. Levstik, R. Hernandez-Alejandro, M. Orloff, R. Kashyap.
Abdominal Transplant, University of Rochester Medical Center, Rochester, NY
Background: Efforts to improve organ utilization have been hindered by a lack of specificity on center's reasons for declining organs. One of the most frequently…
2017 American Transplant Congress
Outcome of Kidney Transplantation from Deceased Octogenarian Donors.
P. Donato, L. Furian, C. Silvestre, F. Neri, C. Di Bella, M. Di Bello, P. Rigotti.
Kidney and Pancreas Transplantation Uniti, Padua University Hospital, Padua, Italy
In order to expand the donor pool, the utilization of kidneys otherwise discarded because of extremely old age or comorbidities has been evaluated.We retrospectively analyzed…
2017 American Transplant Congress
Preservation of Musculoskeletal Components in Vascularized Composite Allograft Skin Rejection.
E. Buckingham, A. Khalifeh, M. Uluer, W. Hassenein, C. Drachenberg, A. Nam, W. Twaddell, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD
Background: Severe or chronic rejection of vascularized composite allografts (VCA) has resulted in graft loss and patient deaths. 'Split tolerance' has been defined in patterns…
2017 American Transplant Congress
Impact of Type 2 Surgical Injuries in Postmortem Donor Kidneys on the Post-Transplant Outcomes When Compared to Mate Non-Injured Kidney from the Same Donor.
M. Mujtaba,¹ A. Gamilla-Crudo,¹ K. Gugliuzza,² O. Aleter,¹ S. Shah,¹ Y. Chapman,³ J. Reese,³ S. Masood,¹ T. Taber.⁴
¹Division of Nephrology and Hypertension, University of Texas Medical Branch, Galveston, TX; ²Department of Surgery, University of Texas Medical Branch, Galveston, TX; ³Southwest Transplant Alliance, Dallas, TX; ⁴Division of Nephrology, Indiana University, Indianapolis, IN
Introduction - While damage to the procured organ is rare with organ loss being approximately 0.3% of procured organs, loss of potential transplantable organs does…
2017 American Transplant Congress
Variables Associated with Liver Graft Utilization and 30-Day Failure: A Liver Graft Quality Index.
J. Tang,¹ M. Esfandiari,¹ A. Zarrinpar.²
¹Statistics, University of California, Los Angeles, CA; ²Surgery, University of California, Los Angeles, CA
The quantitative evaluation of liver graft quality remains one of the most understudied clinical problems in transplantation. A few scoring systems have been proposed, but…
2017 American Transplant Congress
Intraomental Non-Purified Islet Transplantation Isolated from DCD Donor Pancreas.
S. Wang, G. Pei, Y. Liu, Z. Wang, B. Zhang, Y. Xie, J. Wang, Z. Shen.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective: We have proved that omentum was a more efficient site to perform non-purified islet transplantation with more safety in Beagle dog islet auto-transplantation model.…
2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹
¹Surgery - Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Pathology, Division of Immunology, Johns Hopkins University, Baltimore, MD; ³Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…
2016 American Transplant Congress
Tolerogenic Interactions Between Host CD8⁺Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.
D. Hongo Apum,¹ X. Zhang,² E. Engleman,² S. Strober.¹
¹Medicine - Division of Immunology & Rheumatology, Stanford University, Stanford, CA; ²Medicine - Department of Pathology, Stanford University, Stanford, CA.
Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…