Articles tagged "Graft acceptance"

2017 American Transplant Congress
Outcome of Kidney Transplantation from Deceased Octogenarian Donors.
P. Donato, L. Furian, C. Silvestre, F. Neri, C. Di Bella, M. Di Bello, P. Rigotti.
Kidney and Pancreas Transplantation Uniti, Padua University Hospital, Padua, Italy
In order to expand the donor pool, the utilization of kidneys otherwise discarded because of extremely old age or comorbidities has been evaluated.We retrospectively analyzed…
2017 American Transplant Congress
Preservation of Musculoskeletal Components in Vascularized Composite Allograft Skin Rejection.
E. Buckingham, A. Khalifeh, M. Uluer, W. Hassenein, C. Drachenberg, A. Nam, W. Twaddell, S. Bartlett, R. Barth.
University of Maryland School of Medicine, Baltimore, MD
Background: Severe or chronic rejection of vascularized composite allografts (VCA) has resulted in graft loss and patient deaths. 'Split tolerance' has been defined in patterns…
2017 American Transplant Congress
Impact of Type 2 Surgical Injuries in Postmortem Donor Kidneys on the Post-Transplant Outcomes When Compared to Mate Non-Injured Kidney from the Same Donor.
M. Mujtaba,¹ A. Gamilla-Crudo,¹ K. Gugliuzza,² O. Aleter,¹ S. Shah,¹ Y. Chapman,³ J. Reese,³ S. Masood,¹ T. Taber.⁴
¹Division of Nephrology and Hypertension, University of Texas Medical Branch, Galveston, TX; ²Department of Surgery, University of Texas Medical Branch, Galveston, TX; ³Southwest Transplant Alliance, Dallas, TX; ⁴Division of Nephrology, Indiana University, Indianapolis, IN
Introduction - While damage to the procured organ is rare with organ loss being approximately 0.3% of procured organs, loss of potential transplantable organs does…
2017 American Transplant Congress
Variables Associated with Liver Graft Utilization and 30-Day Failure: A Liver Graft Quality Index.
J. Tang,¹ M. Esfandiari,¹ A. Zarrinpar.²
¹Statistics, University of California, Los Angeles, CA; ²Surgery, University of California, Los Angeles, CA
The quantitative evaluation of liver graft quality remains one of the most understudied clinical problems in transplantation. A few scoring systems have been proposed, but…
2017 American Transplant Congress
Intraomental Non-Purified Islet Transplantation Isolated from DCD Donor Pancreas.
S. Wang, G. Pei, Y. Liu, Z. Wang, B. Zhang, Y. Xie, J. Wang, Z. Shen.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective: We have proved that omentum was a more efficient site to perform non-purified islet transplantation with more safety in Beagle dog islet auto-transplantation model.…
2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹
¹Surgery - Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Pathology, Division of Immunology, Johns Hopkins University, Baltimore, MD; ³Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…
2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
S. Busque, J. Scandling, J. Shizuru, R. Lowsky, A. Shori, J. Kent, E. Engleman, S. Strober.
Stanford University, Stanford
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…
2017 American Transplant Congress
TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.
Q. Ding, K. Mohib, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh
B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…
2017 American Transplant Congress
Utility of IL-2 Complexes in Promoting Vascularized Composite Allograft Survival.
H. Xu,¹ S. Dahiya,² L. Wang,² T. Akimova,² W. Hancock,^2,4 S. Levin.³
¹Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ³Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
Vascularized composite allografts (VCA) are a novel, life-enhancing form of transplantation (Tx). The complexity of host immune responses to VCA tissues, especially those involving skin,…
2016 American Transplant Congress
Understanding the Initial Rise in Kidney Discard Rates Observed Post-KAS.
D. Stewart,¹ A. Kucheryavaya,¹ R. Brown,¹ D. Klassen,¹ N. Turgeon,² M. Aeder.³
¹UNOS, Richmond, VA; ²Emory Univ, Atlanta, GA; ³Univ Hosp Case Med Ctr, Cleveland, OH.
Background: Kidney discard rates increased by 10% -- from 18.3% to 20.2% (p=0.001) -- during the first 7 months of KAS but returned to pre-KAS…