Articles tagged "Graft acceptance"

2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam³, B. Schreiber³, A. Wagaa-Gasser¹, A. Chandraker⁴
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Nephrology, Clinica Universidad de Navarra, Ripagaina, Spain, ³Brigham and Women's Hospital, Boston, MA, ⁴Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…
2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
W. Burlingham¹, E. Jankowska-Gan², J. Fechner³, C. Little², J. Sullivan⁴, D. Foley¹
¹University of Wisconsin, Madison, WI, ²Surgery-Transplant Division, University of Wisconsin, Madison, WI, ³Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, ⁴Surgery, University of Wisconsin, Madison, WI
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…
2022 American Transplant Congress
Impact of the Weekend Effect on Adult and Pediatric Liver or Kidney Offer Acceptance
T. Yamamoto, M. Fruscione, A. Shah, L. Dageforde, S. Kimura, H. Yeh, N. Elias, T. Kawai, J. F. Markmann
Transplant Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Weekends may impose resource and manpower constraints on hospitals. Studies using data from prior allocation schemas showed increased adult organ discards on weekends. We…
2022 American Transplant Congress
Resistance Isn’t Futile: The Independent Effect of Pumping Resistance on Long-Term Kidney Graft Survival
D. Stewart¹, J. Foutz¹, L. Kamal², G. Gupta²
¹United Network for Organ Sharing, Richmond, VA, ²Virginia Commonwealth University Health, Richmond, VA
*Purpose: Kidneys are pumped for therapeutic (to mitigate deleterious effects of ischemia), practical (to facilitate transplant scheduling), and prognostic (to assess organ quality) purposes. Yet…
2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
J. Mello Offerni¹, D. Matty², H. Abed³, P. Roshanov⁴, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Undergraduate Medical Education, Western University, Schulich School of Medicine & Dentistry, London, ON, Canada, ³Division of Urology, Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Division of Nephrology, Department of Internal Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
An Acceptable Challenge for Specialized Transplant Centres: Small Kidney Donors for Small Recipients
R. Büscher, M. Cetiner, P. F. Hoyer, A. K. Büscher
Department of Pediatrics II, University Hospital Essen, Essen, Germany
*Purpose: Kidneys from small donors (SDK, donor weight
2022 American Transplant Congress
Expanded Criteria Donor with Severe Acute Kidney Injury: Worth to Use?
S. Thotsiri, N. Sutharattanapong, C. Janphram, P. Wiwattanathum
Excellent Center of Organ Transplantation, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
*Purpose: Because of organ shortage, the world facing problem, expanded criteria donor (ECD) was utilized to increase donor pool. Although long term allograft survival from…
2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
V. Fleetwood¹, D. Axelrod², Y. Caliskan¹, H. Randall¹, J. Wellen³, M. Lichtenberger³, C. Dedert¹, R. Rothweiler⁴, G. F. Marklin⁴, D. Brockmeier⁴, M. A. Schnitzler¹, S. A. Husain⁵, S. Mohan⁵, B. Kasiske⁶, M. Cooper⁷, K. L. Lentine¹
¹Saint Louis U., St. Louis, MO, ²U. of Iowa, Iowa City, IA, ³WUSTL, St. Louis, MO, ⁴Mid-Am. Trans., St. Louis, MO, ⁵Columbia U., New York, NY, ⁶Hennepin Healthcare, Minneapolis, MN, ⁷MedStar Transpl. Inst., Washington, DC
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
2022 American Transplant Congress
Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells
J. Zhao¹, S. Jung¹, X. Li¹, H. Zhang¹, S. Movahedi¹, V. Kasinath¹, M. Uehara¹, J. Azzi¹, P. Sage¹, S. Tullius¹, J. S. Bromberg², R. Abdi¹
¹Brigham and Women's Hospital, Boston, MA, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…

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