2018 American Transplant Congress
Early Evolution and Pathologic Characteristics of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts
Introduction: The kidney is pro-tolerogenic by mechanisms as yet unknown. In mice, tolerance of kidney allografts can occur spontaneously in certain strain combinations, such as…2018 American Transplant Congress
Endoplasmic Reticulum Stress Sensor IRE1α Deficiency Promotes Infiltrating Macrophage Polarization and Induces Long-Term Renal Allograft Acceptance in Mice
Objective: Macrophage is involved in the pathogenesis of I/R injury and allograft rejection. However, the mechanisms underlying this is vastly unknown. This study aims to…2018 American Transplant Congress
Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction
How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…2018 American Transplant Congress
Skeletons in the Closet? An Insight into Donor Liver Discards in the US
Weill Cornell Medicine, NY, NY.
Background Liver discards are poorly investigated. Among these discarded livers are potentially useable grafts that could save the lives of many of the 2500-3000 who…2018 American Transplant Congress
Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation
Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…2018 American Transplant Congress
Kidney Allografts Confer Tolerance upon Co-Transplanted Heart Allografts by Promoting Tregs
The same mixed chimerism-based protocol that induces tolerance of nonhuman primate kidney allografts results in rejection of heart allografts. However, when the two organs from…2018 American Transplant Congress
Use of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients: Recipient Characteristics
1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.
Purpose: The number of donors labeled as Public Health Service Increased Risk (IR) is rising. This designation identifies organs from donors at 'increased risk' of…2018 American Transplant Congress
Utilization of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients by Era
1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.
Purpose: Donors labeled Public Health Service Increased Risk (PHS-IR) continue to rise due to opioid abuse and expanding criteria defining 'increased-risk.' Many PHS-IR donors are…2018 American Transplant Congress
Why the Low Usage of HIV Positive Donors? A Survey of the Transplant Community
BackgroundSince the HIV Policy Equity Act of 2013, 22 programs have been approved to use HIV+ kidneys and livers, yet these transplants remain uncommon. It…2018 American Transplant Congress
Vascular Allografts in Renal Transplantation
Solid Organ Transplantation, Cleveland Clinic Florida, Weston, FL.
Vascular allografts are used routinely in pancreas, intestine and occasionally in liver transplantation. We propose that selective use of vascular allografts may increase utilization of…
American Transplant Congress abstracts