ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft acceptance"

  • 2016 American Transplant Congress

    Targeting IFN-g-Expressing TIM-4+ B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.

    Q. Ding,1 K. Mohib,1 S. Xiao,2 V. Kuchroo,2 D. Rothstein.1

    1University of Pittsburgh, Pittsburgh; 2Harvard Medical School, Boston.

    B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…
  • 2016 American Transplant Congress

    Everolimus in Combination with Reduced Dose Tacrolimus Is Effective as a Prophylaxis of Acute Rejection in Low-to-Moderate Immunologic Risk De Novo Kidney Transplantation Patients.

    Y. Qazi, F. Shihab, S. Mulgaonkar, K. MaCague, D. Patel.

    University of Southern California, Los Angeles; University of Utah, Salt Lake City; Barnabas Health, West Orange; Novartis Pharmaceuticals Corporation, East Hanover.

    The US92 study determined whether, in de novo renal transplant patients (pts), concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®…
  • 2016 American Transplant Congress

    Distinct Phenotype and Function of Plasmacytoid Dendritic Cells from Kidney Allografts in Tolerant Recipients.

    N. Oh,1,2 C. Yang,1,2,3 M. Tonsho,1,2 D. Ndishabandi,1,2,3 P. Russell,1,2 R. Colvin,1,3 J. Madsen,1,2 A. Alessandrini.1,2

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Department of Surgery, Massachusetts General Hospital, Boston, MA; 3Department of Pathology, Massachusetts General Hospital, Boston, MA.

    BACKGROUND: Cellular infiltrates in kidney allografts may be relevant to the induction or maintenance of regulatory tolerance. Here we examined the phenotype, anatomical distribution and…
  • 2016 American Transplant Congress

    Tolerogenic Interactions Between Host CD8+Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.

    D. Hongo Apum,1 X. Zhang,2 E. Engleman,2 S. Strober.1

    1Medicine - Division of Immunology & Rheumatology, Stanford University, Stanford, CA; 2Medicine - Department of Pathology, Stanford University, Stanford, CA.

    Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…
  • 2016 American Transplant Congress

    Understanding the Initial Rise in Kidney Discard Rates Observed Post-KAS.

    D. Stewart,1 A. Kucheryavaya,1 R. Brown,1 D. Klassen,1 N. Turgeon,2 M. Aeder.3

    1UNOS, Richmond, VA; 2Emory Univ, Atlanta, GA; 3Univ Hosp Case Med Ctr, Cleveland, OH.

    Background: Kidney discard rates increased by 10% -- from 18.3% to 20.2% (p=0.001) -- during the first 7 months of KAS but returned to pre-KAS…
  • 2016 American Transplant Congress

    Rapamycin (RPM) Synergizes with CD154 mAb and DST to Promote Long-Term Vascularized Composite Allograft (VCA) Survival, but Prevents Induction of Donor-Specific Tolerance.

    L. Wang, Z. Wang, R. Han, T. Bhatti, L. Levin, M. Levine, W. Hancock.

    CHOP & UPenn, Philadelphia.

    Even though CD154 mAb (MR-1) plus donor splenocyte transfusion (DST) is very effective at inducing tolerance of various allografts, such as those of hearts, kidneys…
  • 2016 American Transplant Congress

    Urinary Expression of miRNA-155, miRNA-210, miRNA-142 and CXCL-10 Production Predicts the Risk of Acute Rejection and Graft Outcome in Renal Transplant Recipients.

    O. Millan,1 K. Budde,2 C. Sommerer,3 I. Aliart,1 O. Rissling,2 B. Bardaji,4 M. Matz,2 M. Zeier,3 I. Silva,4 L. Guirado,4 M. Brunet.1

    1Pharmacology Laboratory, CDB, IDIBAPS, Hospital Clinic Barcelona, Barcelona University, Barcelona, Spain; 2Medizinische Klinik mit Schwerpunkt Nephrologie, Charité Universitätsmedizin, Berlin, Germany; 3Department of Nephrology, University Hospital Heidelberg and Mannheim, Heidelberg, Germany; 4Renal Transplant Unit, Fundació Puigvert, Barcelona, Spain.

    MicroRNAs (miRs) have been reported to play a role in immune system response. The results of several clinical trials have suggested that these molecules might…
  • 2016 American Transplant Congress

    Treg-Rich Organized Lymphoid Structures (TOLS) in Spontaneously Accepted Mouse Kidney Allografts.

    C. Yang,1 E. Farkash,2 D. Ndishabandi,1 R. White,1 B. Jiang,1 I. Aljabban,1 P. Russell,1 J. Madsen,1 R. Colvin,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Dept. of Surgery, Dept. of Pathology, Massachusetts General Hospital, Boston, MA; 2University of Michigan School of Medicine, Ann Arbor, MI.

    Background: In many MHC mismatched strain combinations (e.g., DBA/2 to B6) kidney allografts are spontaneously accepted without immunosuppression. This tolerance is regulatory, initially dependent Foxp3+…
  • 2016 American Transplant Congress

    A Weighted Approach to Composite Efficacy Analysis in Kidney Transplantation.

    B. Kaplan, K. MaCague, D. Patel, F. Vincenti.

    Mayo Clinic, Phoenix; Novartis Pharmaceuticals Corporation, East Hanover; University of California, San Francisco.

    The US92 study determined whether, in de novo renal transplant patients, concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior to CellCept® (mycophenolate mofetil…
  • 2016 American Transplant Congress

    The Impact of Gender Discordance on Graft Survival Among Liver Transplant Recipients.

    J. Moore, X. Luo, A. Massie, T. Purnell, D. Mogul, D. Segev.

    Johns Hopkins School of Medicine, Baltimore.

    Past studies have shown inferior liver graft survival in gender-discordant recipient/donor pairings compared to gender-matched pairings, particularly in male recipients of female donor livers. However,…
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