Articles tagged "Graft acceptance"

2018 American Transplant Congress
Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation
A. Kwong,¹ A. Wall,² M. Melcher,² U. Wang,³ A. Ahmed,¹ K. Khush,³ A. Subramanian,³ J. Tan,³ P. Kwo.¹
¹Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; ²Surgery, Stanford University, Palo Alto, CA; ³Stanford University, Palo Alto, CA.
Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
2018 American Transplant Congress
Kidney Allografts Confer Tolerance upon Co-Transplanted Heart Allografts by Promoting Tregs
C. Yang,¹ T. Ashry,¹ I. Rosales,² J. Ge,¹ T. O'Shea,¹ R. White,² P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.¹
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston; ²Department of Pathology, Massachusetts General Hospital, Boston.
The same mixed chimerism-based protocol that induces tolerance of nonhuman primate kidney allografts results in rejection of heart allografts. However, when the two organs from…
2018 American Transplant Congress
Use of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients: Recipient Characteristics
M. Meyers,¹ J. Shults,¹ B. Laskin,¹ P. Porrett,² M. Levine,² P. Abt,² S. Amaral,^1,2 D. Goldberg.¹
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Purpose: The number of donors labeled as Public Health Service Increased Risk (IR) is rising. This designation identifies organs from donors at 'increased risk' of…
2018 American Transplant Congress
Utilization of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients by Era
M. Meyers,¹ J. Shults,¹ B. Laskin,¹ P. Porrett,² M. Levine,² P. Abt,² S. Amaral,^1,2 D. Goldberg.²
¹Children's Hospital of Philadelphia, Philadelphia; ²University of Pennsylvania, Philadelphia.
Purpose: Donors labeled Public Health Service Increased Risk (PHS-IR) continue to rise due to opioid abuse and expanding criteria defining 'increased-risk.' Many PHS-IR donors are…
2018 American Transplant Congress
Why the Low Usage of HIV Positive Donors? A Survey of the Transplant Community
S. Nazarian,¹ C. Watts,² D. Sawinski,² P. Reese,² D. Goldberg,² P. Abt,¹ S. Halpern,² J. Shea,² E. Blumberg.²
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA.
BackgroundSince the HIV Policy Equity Act of 2013, 22 programs have been approved to use HIV+ kidneys and livers, yet these transplants remain uncommon. It…
2018 American Transplant Congress
Vascular Allografts in Renal Transplantation
D. Reino, G. Schnickel, E. Ale, S. Ebaid, N. Agrawal, S. Rhazouani, S. Gebreselassie, A. Tzakis.
Solid Organ Transplantation, Cleveland Clinic Florida, Weston, FL.
Vascular allografts are used routinely in pancreas, intestine and occasionally in liver transplantation. We propose that selective use of vascular allografts may increase utilization of…
2018 American Transplant Congress
TACI Polymorphisms Associated with Allograft Rejection in Mice and in Man
M. Barbosa,¹ E. Farkash,² J. Platt,³ M. Cascalho.³
¹Surgery, University of Michigan, Ann Arbor, MI; ²Pathology, University of Michigan, Ann Arbor, MI; ³Surgery/Microbiology and Immunology, University of Michigan, Ann Arbor, MI.
Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants in healthy individuals. In fact, TACI is…
2018 American Transplant Congress
Accommodation and Antibody Mediated Rejection Are Associated with Distinct TACI Polymorphisms in Kidney Transplant Recipients
M. Cascalho, M. Barbosa,¹ E. Farkash,² J. Platt.¹
¹Surgery, University of Michigan, Ann Arbor, MI; ²Pathology, University of Michigan, Ann Arbor, MI.
A. Trans-membrane Activator and CAML Interactor (TACI) gene is among the 5% most polymorphic genes in humans, TACI controls B cell differentiation and memory and…
2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
S. Busque, J. Scandling, J. Shizuru, R. Lowsky, A. Shori, J. Kent, E. Engleman, S. Strober.
Stanford University, Stanford
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…
2017 American Transplant Congress
TIM-4 Identifies Pro-Inflammatory B Effector Cells That Are Potent Drivers of Alloimmunity and Allograft Rejection Through Expression of Both IFN-γ and IL-17.
Q. Ding, K. Mohib, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh
B cells can either augment or inhibit immune responses due to the presence both regulatory (Bregs) and effector (Beff) B cells expressing anti- or pro-…

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