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Articles tagged "Graft acceptance"

  • 2018 American Transplant Congress

    Early Evolution and Pathologic Characteristics of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts

    C. Yang,1 I. Rosales,2 T. O'Shea,1 D. Ndishabandi,2 R. White,2 P. Russell,1 J. Madsen,1 A. Alessandrini,1 R. Colvin.2

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston; 2Department of Pathology, Massachusetts General Hospital, Boston.

    Introduction: The kidney is pro-tolerogenic by mechanisms as yet unknown. In mice, tolerance of kidney allografts can occur spontaneously in certain strain combinations, such as…
  • 2018 American Transplant Congress

    Endoplasmic Reticulum Stress Sensor IRE1α Deficiency Promotes Infiltrating Macrophage Polarization and Induces Long-Term Renal Allograft Acceptance in Mice

    L. Qiu,1 J-.J. Wang,1 X. Yeap,1 D. Fang,2 J. Zhang.1

    1Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Objective: Macrophage is involved in the pathogenesis of I/R injury and allograft rejection. However, the mechanisms underlying this is vastly unknown. This study aims to…
  • 2018 American Transplant Congress

    Ablation of IRF4 Induces Transplant Tolerance by Driving Intrinsic T Cell Dysfunction

    J. Wu,1,2 H. Zhang,1 X. Shi,1 X. Xiao,1 Y. Fan,1 J. Xia,2 R. Sciammas,1,3 X. Li,1,3 W. Chen.1,3

    1Center for Immunobiology & Transplant Science, Houston Methodist Research Institute, Houston, TX; 2Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; 3Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.

    How transplant rejection is regulated on a transcriptional level remains unclear. We found that T cell-specific conditional knockout (cKO) of the transcription factor IRF4 in…
  • 2018 American Transplant Congress

    Skeletons in the Closet? An Insight into Donor Liver Discards in the US

    K. Halazun, A. Rana, G. Roll, P. Tabrizian, V. Agopian, B. Samstein, R. Brown, J. Emond.

    Weill Cornell Medicine, NY, NY.

    Background Liver discards are poorly investigated. Among these discarded livers are potentially useable grafts that could save the lives of many of the 2500-3000 who…
  • 2018 American Transplant Congress

    Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation

    A. Kwong,1 A. Wall,2 M. Melcher,2 U. Wang,3 A. Ahmed,1 K. Khush,3 A. Subramanian,3 J. Tan,3 P. Kwo.1

    1Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; 2Surgery, Stanford University, Palo Alto, CA; 3Stanford University, Palo Alto, CA.

    Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
  • 2018 American Transplant Congress

    Kidney Allografts Confer Tolerance upon Co-Transplanted Heart Allografts by Promoting Tregs

    C. Yang,1 T. Ashry,1 I. Rosales,2 J. Ge,1 T. O'Shea,1 R. White,2 P. Russell,1 J. Madsen,1 R. Colvin,2 A. Alessandrini.1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston; 2Department of Pathology, Massachusetts General Hospital, Boston.

    The same mixed chimerism-based protocol that induces tolerance of nonhuman primate kidney allografts results in rejection of heart allografts. However, when the two organs from…
  • 2018 American Transplant Congress

    Use of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients: Recipient Characteristics

    M. Meyers,1 J. Shults,1 B. Laskin,1 P. Porrett,2 M. Levine,2 P. Abt,2 S. Amaral,1,2 D. Goldberg.1

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Purpose: The number of donors labeled as Public Health Service Increased Risk (IR) is rising. This designation identifies organs from donors at 'increased risk' of…
  • 2018 American Transplant Congress

    Utilization of Public Health Service Increased Risk Kidneys in Pediatric Renal Transplant Recipients by Era

    M. Meyers,1 J. Shults,1 B. Laskin,1 P. Porrett,2 M. Levine,2 P. Abt,2 S. Amaral,1,2 D. Goldberg.2

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Purpose: Donors labeled Public Health Service Increased Risk (PHS-IR) continue to rise due to opioid abuse and expanding criteria defining 'increased-risk.' Many PHS-IR donors are…
  • 2017 American Transplant Congress

    Early Evolution and Immunopathologic Phenotype of Treg-Rich Organized Lymphoid Structures (TOLS) Associated with Immunological Tolerance in Accepted Mouse Kidney Allografts.

    C. Yang,1 I. Rosales,2 E. Farkash,3 D. Ndishabandi,1,3 R. White,3 P. Russell,1 J. Madsen,1 A. Alessandrini,1,3 R. Colvin.1,3

    1Center for Transplantation Sciences, Mass General Hospital, Boston, MA; 2Department of Pathology, Mass General Hospital, Boston, MA; 3Department of Pathology, University of Michigan, Ann Arbor, MI

    Introduction: Lymphoid neogenesis has been found in allografts after organ transplant. We previously reported that spontaneously accepted DBA/2 to B6 kidney allografts developed distinctive, peri-arterial…
  • 2017 American Transplant Congress

    “Donor Age or Quality” a Qualitative Analysis of Livers Declined for 830.

    M. Dokus, E. DeAngelis, G. Ramaraju, K. Tomiyama, J. Huang, M. Levstik, R. Hernandez-Alejandro, M. Orloff, R. Kashyap.

    Abdominal Transplant, University of Rochester Medical Center, Rochester, NY

    Background: Efforts to improve organ utilization have been hindered by a lack of specificity on center's reasons for declining organs. One of the most frequently…
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