ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene polymorphism"

  • 2020 American Transplant Congress

    Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients

    L. Callans, J. Obayemi, H. Gao, A. Shaked, B. Chang, B. Keating

    Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, USA, Philadelphia, PA

    *Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…
  • 2020 American Transplant Congress

    Impact of CYP3A5 Phenotype on Early Time in Therapeutic Range among Pediatric Renal and Heart Transplant Recipients

    A. Leino, A. Pasternak

    University of Michigan, Ann Arbor, MI

    *Purpose: Tacrolimus time in therapeutic range (TTR) as a measure of intra-patient variability has been associated with poor long-term outcomes. Multiple factors may contribute to…
  • 2020 American Transplant Congress

    FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis

    J. Zhang, J. Chen

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
  • 2020 American Transplant Congress

    A Single Nucleotide Polymorphism of Tweak Predicts Arterio- and Arteriolohyalinosis in Kidney Transplants and is Associated with Allograft Survival

    A. Karolin1, D. Thottan1, J. Zinsli1, S. Rudloff1, U. Huynh-Do1, V. Banz2, T. Berney3, M. Pascual4, T. Müller5, P. d’Amico6, I. Binet7, D. Sidler1

    1Nephrology and Hypertension, University Bern, Bern, Switzerland, 2University Bern, Bern, Switzerland, 3University Hospital Genevia, Genevia, Switzerland, 4University Hospital Lausanne, Lausanne, Switzerland, 5University Hospital Zurich, Zurich, Switzerland, 6Hospital St.Gallen, St.Gallen, Switzerland, 7University Hospital Basel, Basel, Switzerland

    *Purpose: We have recently demonstrated that the TNF superfamily member is critical for the pathogenesis of Calcineurin Inhibitor Toxicity (CNT). CNT is a common side…
  • 2020 American Transplant Congress

    Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients

    N. Nesselhauf1, S. January1, J. Hagopian1, K. Progar1, A. Khan2

    1Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 2Surgery, Washington University School of Medicine, St. Louis, MO

    *Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
  • 2019 American Transplant Congress

    Natural Killer Cells Express Significantly More CD16 during Chronic Active Antibody Mediated Rejection Which is Not Caused by a Single Nucleotide Polymorphism within the CD16 Gene

    K. Sablik, N. Litjens, A. Peeters, M. Clahsen-van Groningen, M. Klepper, M. Betjes

    Erasmus MC, Rotterdam, Netherlands

    *Purpose: Chronic-active antibody mediated rejection (c-aABMR) is the leading cause of long-term renal allograft loss. Fc-receptor CD16 bearing natural killer (NK) cells may be involved…
  • 2019 American Transplant Congress

    CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation

    J. E. Kimpton, A. J. Hughes, I. MacPhee

    Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

    *Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…
  • 2019 American Transplant Congress

    Phylogenetic Analysis of the Epstein Barr Virus Nuclear Antigen-1 and Associated Correlates among Canadian Transplant Patients

    M. Abdulnoor1, S. Isabel1, T. Paton1, N. Khodai-Booran1, T. Schechter1, P. Birk2, T. Blydt-Hansen3, B. Foster4, S. Mital1, V. Phan5, S. Urschel6, G. Casallo1, T. Papaz1, L. Hamiwka7, S. Min1, U. Allen1

    1University of Toronto, Toronto, ON, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3University of British Columbia, Vancouver, BC, Canada, 4McGill University, Montreal, QC, Canada, 5University of Montreal, Montreal, QC, Canada, 6University of Alberta, Edmonton, AB, Canada, 7University of Calgary, Calgary, AB, Canada

    *Purpose: The effect of the genetic diversity of the Epstein-Barr virus (EBV) on clinical outcomes in the transplant setting is important to study. We examined…
  • 2019 American Transplant Congress

    Studying the Association of Melanocortin Receptor-4 Gene Polymorphism and Renal Transplant Rejection

    F. Yilmaz1, R. Abdi1, B. J. Keating2, V. R. Mas3

    1Renal Division, Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Surgery, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 3Director Transplant Research Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Accumulating experimental data highlight the importance of targeting the innate immune response to improve transplant outcomes. Inflammation is an unavoidable consequence of transplantation. The…
  • 2019 American Transplant Congress

    CNV Screening For End-stage Renal Disease

    C. E. Fishman, B. Chang, A. Shaked, B. J. Keating

    Surgery, University of Pennsylvania, Philadelphia, PA

    *Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
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