2022 American Transplant Congress
Identification of a Donor Kidney with Heterozygous COL4A3-related Alport Syndrome in a Homozygous Recipient Highlighting the Importance of Genetic Testing
1CLS Health, Webster, TX, 2Natera, Inc., Austin, TX, 3Baylor College of Medicine, Houston, TX
*Purpose: Selection of an appropriate donor for kidney transplantation can mitigate the risk of rejection and increase the chances of graft survival. While immunologic matching…2022 American Transplant Congress
Significance of Gene Polymorphism on Infectious Complications and Rejection After Liver Transplantation
*Purpose: Clinical application of gene polymorphism is a key of precision medicine in the field of organ transplantation. Hiroshima group reported significance of Fc-gamma receptor…2021 American Transplant Congress
Higher Number of Tacrolimus Dose Adjustments and Trough Level Measurements in Kidney Transplant Recipients with CYP3A5*1 Alleles
*Purpose: Tacrolimus (TAC) metabolism is dependent on the functional status of the cytochrome P450 family enzyme CYP3A5 which has three common loss of function (LoF)…2021 American Transplant Congress
Cyp3a5 Extensive Metabolizer Phenotype May be Associated with an Increase in Class 2 Donor Specific Antibodies and Antibody-Mediated Rejection
*Purpose: Tacrolimus (TAC) metabolism is highly dependent on CYP3A5, yet there is limited data on the effect of CYP3A5 genetic polymorphisms in heart transplant recipients…2021 American Transplant Congress
A Single Nucleotide Polymorphism within the FCGR3A 158 F/V Gene is Associated with Decreased Survival of Renal Allografts with Chronic Active Antibody-Mediated Rejection
*Purpose: Long-term allograft survival has shown little improvement over the last decades. An important factor compromising long-term allograft survival in kidney transplantation is chronic active…2021 American Transplant Congress
Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients
*Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…2020 American Transplant Congress
Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients
*Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…2020 American Transplant Congress
Impact of CYP3A5 Phenotype on Early Time in Therapeutic Range among Pediatric Renal and Heart Transplant Recipients
University of Michigan, Ann Arbor, MI
*Purpose: Tacrolimus time in therapeutic range (TTR) as a measure of intra-patient variability has been associated with poor long-term outcomes. Multiple factors may contribute to…2020 American Transplant Congress
FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
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