Date: Saturday, June 1, 2019
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall C & D
*Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine whether CYP3A5 genotype is a contributory factor.
*Methods: We performed a retrospective observational analysis of 295 patients who underwent renal transplantation between 1995 and 2017. CYP3A5 genotypes of *1/*1, *1/*3 or *1/*3 were determined. Serum creatinine, trough tacrolimus concentration and tacrolimus dose were recorded at day 7, day 14 and 3 months post-transplantation. Glomerular filtration rate was estimated using the CKD-EPI equation (eGFR). Groups were compared by the Kruskal-Wallis H test.
Table 1. Mean blood tacrolimus trough concentrations, tacrolimus doses and concentration/dose ratios by CYP3A5 genotype across all time points.
|*1/*1 (n=27)||*1/*3 (n=81)||*3/*3 (n=187)||P value|
|Tacrolimus mean concentration (ng/ml)||10.94±4.66||11.73±4.29||13.94±6.05||<0.0001|
|Tacrolimus mean daily dose (mg)||19.33±6.20||15.41±5.81||11.00±4.93||<0.0001|
|Mean concentration/dose ratio (ng/mL*1/mg)||0.78±0.82||0.90±0.48||1.53±0.72||<0.0001|
Table 2. Mean eGFR (ml/min/1.73m2) by CYP3A5 genotype at day 7, day 14 and 3 months after renal transplantation.
|*1/*1 (n=27)||*1/*3 (n=81)||*3/*3 (n=187)||P-value|
*Conclusions: As expected, individuals with CYP3A5 expressor genotypes (CYP3A5*1/*1 and *1/*3) were shown to require higher daily doses of tacrolimus and had lower tacrolimus trough concentrations than nonexpressors (CYP3A5*3/3) (Table 1). Despite this, CYP3A5 genotype did not influence renal function at any time point (Table 2). CYP3A5 genotype does not appear to be a risk factor for predicting the development of tacrolimus nephrotoxicity.
To cite this abstract in AMA style:Kimpton JE, Hughes AJ, MacPhee I. CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/cyp3a5-genotype-had-no-influence-on-renal-function-after-renal-transplantation/. Accessed February 27, 2021.
« Back to 2019 American Transplant Congress